Adult patients undergoing robotic kidney transplantation. The transplant operation will be undertaken using the da Vinci systems robot in minimally invasive fashion.

Adult patients undergoing kidney transplantation via an open approach.

Adult patients undergoing donor nephrectomy will have a scan of their abdominal wound to compare wound healing.

Transplant;Failure,Kidney

Transplantation of a kidney either by open surgery or robotic assisted laparoscopic surgery.

kidney transplant

Minimally Invasive Kidney Transplantation

Minimally Invasive Kidney Transplantation: Surgical Stress and Kidney Injury

KIM-1, NGAL and Interleukin 18 will be measured pre-op and post operatively up to day 30.

Assessed by clinical markers such as infection and by ultrasound scan of incisions.

Guy's and St Thomas' NHS Foundation Trust

Once daily treatment with oral dapagliflozin (forxiga) 10mg for 12 consecutive weeks.

Once daily treatment with oral gliclazide MR 30mg for 12 consecutive weeks.

Once daily treatment with oral dapagliflozin (forxiga) 10mg for 12 consecutive weeks.
Dapagliflozin 10mg QD: Dapagliflozin 10mg once daily for 12 weeks

Dapagliflozin 10mg Once Daily

Once daily treatment with oral gliclazide MR 30mg for 12 consecutive weeks.
Gliclazide 30mg QD: Gliclazide30mg once daily for 12 weeks

Gliclazide Modified Release 30mg Once Daily

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Region of Enrollment

Calculated from urinary and plasma inulin concentrations, GFR in ml/min

Glomerular Filtration Rate (GFR) in ml/Min

Calculated from urinary and plasma para-aminohippurate concentrations, ERPF in ml/min

Effective Renal Plasma Flow (ERPF) in ml/Min

Calculated fractional excretions with measured GFR (see above) and urinary and plasma concentrations of sodium. Fractional excretion in % of filtered sodium

Fractional Excretion of Sodium in % of Filtered Sodium

Calculated fractional excretions with measured GFR (see above) and urinary and plasma concentrations of potassium. Fractional excretion in % of filtered potassium

Fractional Excretion of Potassium in % of Filtered Potassium

Calculated fractional excretions with measured GFR (see above) and urinary and plasma concentrations of glucose. Fractional excretion in % of filtered glucose

Fractional Excretion of Glucose in % of Filtered Glucose

Calculated from measured urinary albumin and creatinin concentrations, in mg/mmol

Urinary Albumin-Creatinine Ratio in mg/mmol

NGAL (ng/mmoll) measured in urine as a marker of renal damage

Neutrophil Gelatinase-associated Lipocalin (NGAL)

KIM-1 (ng/mmol) measured in urine as a marker of renal damage

Kidney Injury Molecule-1 (KIM-1) in ng/mmol

Body Weight

Blood pressure will be measured using an automated oscillometric blood pressure device (Dinamap®) in mmHg

Systolic Blood Pressure

Overall Study

Erik van Bommel

Diabetes Mellitus, Type 2

Diabetic Nephropathies

Dapagliflozin 10mg once daily for 12 weeks

Dapagliflozin 10mg QD

Gliclazide 30mg QD

VU University Medical Center

Renoprotective Effects of Dapagliflozin in Type 2 Diabetes

A Randomized, Double-blind, Comparator-controlled Trial to Assess the Effect of 12-week Treatment With Dapagliflozin Versus Gliclazide on Renal Physiology and Biomarkers in Metformin-treated Patients With Type 2 Diabetes Mellitus

M.H.H. Kramer

Head of the Internal Medicine department

AstraZeneca

Obstructive Sleep Apnea

Acute Kidney Failure

Chronic Kidney Disease

After being qualified into the study according to the aforementioned inclusion criteria and after giving an informed consent the polysomnography will be performed in all patients during night rest.In all patients eligible to sleep apnea treatment according to apnea/hypopnea index (AHI, number of apneic/hypopneic episodes per 1 h of effective sleep) from diagnostic polysomnography, CPAP treatment will be introduced under polysomnographic surveillance and the same panel of clinical and biochemical parameters will be evaluated.

continuous positive airway pressure (CPAP)

Medical University

Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function

Effect of Correction of Obstructive Sleep Apnea With Positive Airway Pressure on Central Blood Pressure and Kidney and Endothelial Function

Professor Michał Nowicki

Medical Universtity of Lodz

Patients with angiographically confirmed significant CAD

gelatinase/fetma

Minimally Invasive Kidney Transplantation

Renoprotective Effects of Dapagliflozin in Type 2 Diabetes

Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function

Neutrophil Gelatinase-associated Lipocalin Concentration in Coronary Artery Disease

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