Patients offered periodontal therapy in 2-4 sittings (n=40), Dental hygiene advised

Patients given standard medical treatment (n=40), Dental hygiene advised

Periodontal Diseases

Cirrhosis

Treatment will be performed by a periodontist.
Intensive removal of subgingival and supragingival calculus and plaque biofilm by scaling, root-planing and polishing. The procedures will be carried out with the use of hand scalers and a piezoelectric ultrasonic scaler with universal tips. Disclosing solution will be used to visualize the plaque for the clinician.
One to four sessions of subgingival scaling and root planing by quadrant, under local anesthesia as may be deemed necessary during the study period.
Subgingival irrigation using an antiseptic mouth rinse (chlorhexidine 0.12%).
Polishing of the coronal and radicular surfaces of the teeth.

Periodontal therapy

Oral hygiene advice

Postgraduate Institute of Medical Education and Research

Periodontal Therapy and Oral-gut-hepatic Axis Cirrhosis: a Randomized Controlled Trial

Effect of Periodontal Therapy and Modification of Oral-gut-hepatic Axis in Patients With Cirrhosis

All-cause, liver-related and elective hospitalizations at 3 months

Madhumita Premkumar

Assistant professor, Department of heaptology

Attention Deficit Hyperactivity Disorder (ADHD)

Binge-Eating Disorder Disorder

dasotraline

Clinical Pharmacology of Miami, Inc.

Orlando Clinical Research Center

Atlanta Center for Medical Research

DaVita Clinical Research

American Research Cororation (ARC), Texas Liver Instituete (TLI)

Study of the What the Body Does to the Drug in Subjects With Mild, Moderate, and Severe Liver Dysfunction

Pharmacokinetics of Orally Administered Dasotraline in Subjects With Mild, Moderate, and Severe Hepatic Dysfunction

Plasma PK parameters: Area under the plasma/serum concentration-time curve from time zero to infinity (AUC0 inf)

Plasma PK parameters: time of occurrence of Cmax

Urine PK parameters: amount excreted in urine from time zero to time t (AEx0 t)

Urine PK parameters: renal clearance (CLR)

Urine PK parameters: percent of dose excreted in urine (%fe)

Unbound fraction of dasotraline in plasma at 10, 12, and 24 hours postdose .

Incidence of adverse events (AEs), SAEs, and AEs resulting in study discontinuation.

Absolute values and changes from baseline in clinical laboratory tests (hematology, serum chemistry, urinalysis, prothrombin time), vital signs (respiratory rate, body temperature, supine blood pressure, and supine pulse rate), and 12 lead ECGs.

Frequency of subjects with suicidal ideation or suicidal behavior using the Columbia Suicide Severity Rating Scale (C SSRS).

Plasma PK parameters: AUC0-last, area under the blood concentration time curve from time zero to 24 hours postdose (AUC0-24)

Plasma PK parameters: time of occurrence of Cmax (tmax)

Plasma PK parameters: apparent clearance (CL/F)

Plasma PK parameters: apparent volume of distribution (Vz/F)

Sunovion

Patients with severe alcoholic hepatitis and good response to therapy.

Patients with severe alcoholic hepatitis and poor response to therapy, that are not candidates to transplantation, according to the specified criteria.

Patients with severe alcoholic hepatitis and poor response to therapy, that are candidates to transplantation, according to the specified criteria.

Alcoholic Hepatitis

Hospital Central de Asturias

Hospital Marqués de Valdecilla

Hospital Clínico Universitario de Santiago

Hospital Puerta de Hierro

Clínica Universidad de Navarra

Hospital Vall d'Hebrón

Hospital Reina Sofía

Hospital Virgen de la Nieves

Complejo Hospitalario Universitario de la Coruña

Hospital Gregorio Marañón

Hospital Ramón y Cajal

Hospital Virgen de la Arrixaca

Hospital Carlos Haya

Hospital Virgen del Rocío

Hospital La Fe

Hospital Río Hortega

Hospital Lozano Blesa

Liver Transplantation in Alcoholic Hepatitis

Applicability of Liver Transplantation in Alcoholic Hepatitis

The survival of patients transplanted with alcoholic hepatitis is going to be compared with the survival of patients with alcoholic hepatitis that are not considered adequate for liver transplantation

The applicability of liver transplantation is defined as the ratio between the number of patients transplanted for alcoholic hepatitis and the number of patients with severe alcoholic hepatitis that do not respond to steroid therapy.

Proportion of patients who are accepted as candidates for liver transplantation who die before transplantation.

Proportion of patients transplanted for alcoholic hepatitis that have a recurrence in alcohol consumption

gerstmann-straussler-scheinker disease/nikotin

Periodontal Therapy and Oral-gut-hepatic Axis Cirrhosis: a Randomized Controlled Trial

Study of the What the Body Does to the Drug in Subjects With Mild, Moderate, and Severe Liver Dysfunction

Liver Transplantation in Alcoholic Hepatitis

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