gestational weight gain/neoplasms

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Pregnancy weight gain and premenopausal breast cancer risk.

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OBJECTIVE To investigate whether excessive weight gain during pregnancy alters a woman's risk of developing premenopausal breast cancer. METHODS We conducted a nested case-control study within a cohort composed of 22,610 Finnish women (mean age, 40; SD 6.4) who responded to a questionnaire

Maternal pre-pregnancy and gestational diabetes, obesity, gestational weight gain, and risk of cancer in young children: a population-based study in California.

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We aimed to examine the influence of pre-pregnancy diabetes, pre-pregnancy body mass index (BMI), gestational diabetes, and gestational weight gain on childhood cancer risk in offspring. We identified cancer cases (n = 11,149) younger than age 6 years at diagnosis from the California Cancer Registry

Pregnancy weight gain and breast cancer risk.

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BACKGROUND: Elevated pregnancy estrogen levels are associated with increased risk of developing breast cancer in mothers. We studied whether pregnancy weight gain that has been linked to high circulating estrogen levels, affects a mother's breast cancer risk. METHODS: Our cohort consisted of women

Perinatal tumor necrosis factor-α production, influenced by maternal pregnancy weight gain, predicts childhood asthma.

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BACKGROUND Innate immune responses marked by increases in tumor necrosis factor (TNF)-α have been associated with asthma but whether such alterations are evident before symptoms is not yet clear. OBJECTIVE To determine if prevalence of childhood asthma or asthma-related traits is predicted by

Maternal factors and breast cancer risk among young women.

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The results from previous studies have provided evidence to support the hypothesised association between intrauterine oestrogen exposure and subsequent risk of breast cancer. Information has not been available to study this relationship for several perinatal factors thought to be related to

Mothers' pre-pregnancy BMI and weight gain during pregnancy and risk of breast cancer in daughters.

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Previous studies have established that higher birthweight is associated with increased risk of breast cancer. However, the mechanisms underlying this association remain unclear. We explored whether maternal pregnancy weight gain and pre-pregnancy body mass index (BMI), which influence birthweight,

Childbearing recency and modifiers of premenopausal breast cancer risk.

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The purpose of this study was to examine the risk of premenopausal breast cancer for women in relation to childbearing recency and whether this association differs by breast-feeding history and/or the amount of weight gained during pregnancy. This analysis was based on data from a population-based

Gestational biomarkers of daughter's breast cancer in the Child Health and Development Studies.

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We examined the link between gestational biomarkers and breast cancer in 9169 daughters born into the Child Health and Development Studies from 1959 to 1967. We identified 137 breast cancer cases diagnosed by age 52 as of 2012. Markers of increased risk included higher placental volume and rapid 2nd

Pregnancy characteristics and maternal risk of breast cancer.

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In a population-based case-control study of parous women less than 45 years of age, we evaluated the relations of various pregnancy characteristics to maternal breast cancer risk. Cases (N = 1,239) diagnosed with in situ or invasive breast cancer from 1990 to 1992 in Atlanta, GA, Seattle/Puget

Circulating metal concentrations, inflammatory cytokines and gestational weight gain: Shanghai MCPC cohort.

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Based on a prospective birth cohort, we aimed to investigate the associations between maternal circulating metals exposure and gestational weight gain (GWG) across pregnancy, and explore whether maternal inflammatory cytokines could contribute to the GWG changes associated with metals

Timing of dietary estrogenic exposures and breast cancer risk.

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The same dietary component, such as fat or phytochemicals in plant foods, can have an opposite effect on breast cancer risk if exposed in utero through a pregnant mother or at puberty. Dietary exposures during pregnancy often have similar effects on breast cancer risk among mothers and their female

Association between adiponectin and tumor necrosis factor-alpha levels at eight to fourteen weeks gestation and maternal glucose tolerance: the Parity, Inflammation, and Diabetes Study.

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OBJECTIVE Inflammation may influence gestational hyperglycemia, but to date, the data from observational studies is largely limited to results from the third trimester of pregnancy. Our objective was to evaluate first trimester adipocytokine levels. We sought to determine whether first trimester

Diet, pregnancy estrogens and their possible relevance to cancer risk in the offspring.

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Total estrogens, estradiol and estriol were determined by radioimmunoassay in the blood of 141 pregnant women during their 26th and 31st weeks of pregnancy, and the results were correlated with dietary patterns and nutrient intakes during pregnancy, assessed through a semiquantitative food frequency

Maternal Metabolic Biomarkers are Associated with Obesity and Excess Gestational Weight Gain.

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The purpose of this study was to evaluate the independent contribution of maternal obesity and gestational weight gain (GWG) in excess of the Institute of Medicine's guidelines on levels of maternal serum inflammatory and metabolic measures. Banked

Factors relating to pregnancy and birth and the risk of childhood brain tumors: results from an Australian case-control study.

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BACKGROUND Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their causes are largely known. This study investigated the association between maternal and birth characteristics and risk of CBT. METHODS Cases families were recruited from all 10 Australian pediatric

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