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Sida 1 från 17 resultat
Method of treatment of cancer using guanosine 3', 5' cyclic monophosphate (cyclic GMP)
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BACKGROUND OF THE INVENTION
Human pancreatic adenocarcinomas have the lowest 5-year survival rate of all common cancers. The five-year survival rate of persons with adenocarcinoma of the pancreas is 1%. The median survival is 4.1 months. Current cancer chemotherapy and surgery prolong survival by a
Method of treatment of cancer using guanosine 3', 5' cyclic monophosphate (cyclic GMP)
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BACKGROUND OF THE INVENTION
Human pancreatic adenocarcinomas have the lowest 5-year survival rate of all common cancers. The five-year survival rate of persons with adenocarcinoma of the pancreas is 1%. The median survival is 4.1 months. Current cancer chemotherapy and surgery prolong survival by a
Cell penetrating anti-guanosine antibody based therapy for cancers with Ras mutations
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REFERENCE TO SEQUENCE LISTING
The Sequence Listing submitted Mar. 4, 2015 as a text file named "YU 6265_ST25.txt," created on Mar. 2, 2015, and having a size of 7,000 bytes is hereby incorporated by reference.
FIELD OF THE INVENTION
The invention relates to the field of anti-cancer therapy and in
2-'-ethenylidene cytidine, uridine and guanosine derivatives
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SUMMARY OF THE INVENTION
The present invention provides novel 2'-halomethylidene derivatives of the formula (1) wherein
V is oxy, methylene, or thio,
X.sub.1 and X.sub.2 are each independently hydrogen or halogen, with the proviso that at least one of X.sub.1 and X.sub.2 is halogen,
B is a radical
2'-halomethylidene, 2'-ethenylidene and 2'-ethynl cytidine, uridine and guanosine derivatives
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SUMMARY OF THE INVENTION
The present invention relates to novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives which are useful as anti-viral and antineoplastic agents.
The present invention provides novel 2'-halomethylidene derivatives of the formula
2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives
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SUMMARY OF THE INVENTION
The present invention relates to novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives which are useful as anti-viral and anti-neoplastic agents.
The present invention provides novel 2'-halomethylidene derivatives of the formula
Compositions for detecting ras gene proteins and cancer therapeutics
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FIELD OF THE INVENTION
This invention relates generally to the field of oncology, and particularly to diagnostic compositions useful in testing for cancer. Additionally, the invention concerns compositions that can be employed both as cancer diagnostics, as well as in a scheme for identifying cancer
Compositions for detecting ras gene proteins and cancer therapeutics
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FIELD OF THE INVENTION
This invention relates generally to the field of oncology, and particularly to diagnostic compositions useful in testing for cancer. Additionally, the invention concerns compositions that can be employed both as cancer diagnostics, as well as in a scheme for identifying cancer
O.sup.6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O.sup.6 -alkylguanine-DNA alkyltransferase depleting activity
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FIELD OF THE INVENTION
The present invention relates to O.sup.6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds which possess the ability to deplete O.sup.6 -alkylguanine-DNA alkyltransferase (AGT) activity in vivo, and to methods for the administration thereof to enhance
Guanosine as an immune potentiator mediated through toll receptors
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TECHNICAL FIELD
The invention relates to preventing and treating infectious diseases and cancer, enhancing an immune response and augmenting the potency of vaccines and immunotherapies by activation of toll like receptor 2 (TLR2) and toll like receptor 4 (TLR4). Embodiments include activation by
Rapid formation of chitosan sponges using guanosine 5'-diphosphate: injectable scaffolds for tissue regeneration and drug delivery
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TECHNICAL FIELD
The present disclosure relates to Guanosine 5'-Diphosphate (GDP) crosslinked chitosan sponges.
BACKGROUND ART
Chitosan has been emerging as a promising biomaterial for a multitude of tissue regeneration and drug delivery applications (Prabaharan, 2008, Journal of Biomaterials
Anti-cancer compositions
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The file of this patent contains at least one drawing executed in color. Copies of this patent with color drawing will be provided by the Patent and Trademark Office upon request and payment of the necessary fee.
The present invention relates to
N.sup.2 (phenyl substituted) deoxy guanosine containing compounds
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BACKGROUND OF THE INVENTION
This invention relates to novel compositions and methods for inhibiting the activity of mammalian DNA polymerase .alpha., bacterial DNA polymerase III or viral-specific DNA polymerases.
Prior to the present invention, 6-substituted uracils of the formula: ##STR8## wherein
Methods of quantifying N.sup.2-(1-carboxyethyl)-2'-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG
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BACKGROUND
Methylglyoxal (MG) is a highly reactive electrophile and is present at micromolar levels in many foods and most living organisms. MG is a major environmental breakdown product of carbohydrates. MG is also generated biochemically during glycolysis via elimination of phosphate from the
Treatment of carcinoma by administration of 2'-halomethylidenyl-2'-deoxynucleosides
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SUMMARY OF THE INVENTION
The present invention relates to novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives which are useful as anti-viral and anti-neoplastic agents.
The present invention provides novel 2'-halomethylidene derivatives of the formula
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