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5 resultat
Soluble guanylate cyclase activators
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BACKGROUND OF THE INVENTION
Cyclic GMP (cGMP) is an important intracellular messenger which triggers a multitude of different effects via the modulation of cGMP-dependent protein kinases, phosphodiesterases and ion channels. Examples are the relaxation of smooth muscles, the inhibition of
Methods for treatment using small molecule potassium-sparing diuretics and natriuretics
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FIELD
This relates to the field of small molecule PNPase substrates and inhibitors as well as potassium-sparing diuretics and natriuretics and methods of their use.
BACKGROUND
With the notable exceptions of mineralocorticoid antagonists and epithelial sodium channel (ENaC) inhibitors, most
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
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This application is related to, not a continuing case to U.S. Pat. Nos. 6,172,060, 6,197,778, 6,177,428, 6,172,068, 6,221,881, 6,232,321, 6,197,782, 6,133,272, and 6,211,179.
FIELD OF THE INVENTION
The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
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FIELD OF THE INVENTION
The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions comprising at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, at least one compound that donates, transfers or
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
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Logga in Bli medlem
FIELD OF THE INVENTION
The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions comprising at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, at least one compound that donates, transfers or
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