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8 resultat
Active hexose correlated compound modulates LPS-induced hypotension and gut injury in rats.
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We hypothesized that AHCC; (Amino UP Chemical Co., Ltd., Sapporo, Japan), a mushroom mycelium extract obtained from liquid culture of Lentinula edodes, restores immune function in LPS-induced inflammation in the gut, especially when the nitric oxide signaling pathway is impaired. This is the first
Age-dependent susceptibility of CNS glial populations in situ to the antimetabolite 6-aminonicotinamide.
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Intraperitoneal injections of the nicotinamide antagonist 6-amino-nicotinamide (6-AN) were used to determine if there are regional differences in putative glial energy metabolism between the developing and adult rat CNS. 6-AN shuts down the hexose monophosphate pathway, which is used preferentially
The potential beneficial effect of glycine on the carbohydrate moieties of glycoproteins in an experimental model of alcohol-induced hepatotoxicity.
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Glycine is known to have a protective role against alcohol-induced liver damage. The aim of our study was to evaluate the effect of glycine on liver and brain glycoproteins in alcohol-fed rats. Administering ethanol (7.9 g/kg of body of weight) every day to Wistar rats for 60 days resulted in
Acute hypertrophic response of skeletal muscle to removal of synergists.
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The purpose of this project was to study the initial rapid enlargement phase of skeletal muscle in response to ablation of synergistic muscles. The first experiment tested the hypothesis that this initial phase is due to inflammation in the enlarging muscle. The wet weight of the plantaris muscle
Biochemical and molecular characterization of the hyaluronidase from Bothrops atrox Peruvian snake venom.
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Snake venoms are a rich source of enzymes such as metalloproteinases, serine proteinases phospholipases A2 and myotoxins, that have been well characterized structurally and functionally. However, hyaluronidases (E.C.3.2.1.35) have not been studied extensively. In this study, we describe the
The resiliency of the corneal endothelium to refractive and intraocular surgery.
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OBJECTIVE
To describe stress factors (phenylephrine and contact lenses) from the corneal epithelium that can affect the corneal endothelium, and to describe the effects of refractive and intraocular surgery on the corneal endothelial structure and function.
METHODS
Significant clinical and
Mannose prevents lipopolysaccharide-induced acute lung injury in rats.
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OBJECTIVE
To investigate the effect of mannose on lipopolysaccharide (LPS) induced acute lung injury (ALI) in rats.
METHODS
Ten groups of Sprague-Dawley rats were used: 1) the control group received an intratracheal instillation of saline, 2) the LPS group received an intratracheal instillation of
A novel therapeutic approach targeting rheumatoid arthritis by combined administration of morin, a dietary flavanol and non-steroidal anti-inflammatory drug indomethacin with reference to pro-inflammatory cytokines, inflammatory enzymes, RANKL and transcription factors.
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The present study was designed to assess the combined efficacy of morin, a dietary flavanol and non-steroidal anti-inflammatory drug indomethacin against adjuvant-induced arthritis in rats, an experimental model for rheumatoid arthritis. Arthritis was induced by intradermal injection of complete
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