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Hoodia gordonii extract targets both adipose and muscle tissue to achieve weight loss in rats.

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BACKGROUND Hoodia gordonii (Masson) Sweet ex Decne (family Apocynaceae) is consumed globally as a natural appetite suppressant. While this effect-and its subsequent effect of weight loss-has been reported in the scientific literature, no information is available on the specific tissue types affected

Evidence for the efficacy and safety of herbal weight loss preparations.

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Rising rates of obesity across the globe have been associated with an increase in the use of herbal preparations for weight control. However, the mechanisms of action for these substances are often not known, as is the potential for interaction with other herbal preparations or prescription

Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder.

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African cactiform Hoodia gordonii (Asclepiadaceae) has been used for thousands of years by Xhomani Bushmen as an anorexant during hunting trips and has been proposed as a new agent for the management of body weight. However, its in vivo targets and molecular mechanisms remain elusive. GPR119, a G

Case report. Efficacy of Hoodia for weight loss: is there evidence to support the efficacy claims?

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Increasing rates of adult obesity and its negative health consequences are likely to become an increasing burden to the Canadian health care system. Consumers are looking for treatment options and often try the natural health products that are heavily promoted as safe, fast and effective. In this

NMR fingerprinting for analysis of hoodia species and hoodia dietary products.

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Hoodia gordonii, a succulent plant growing in African arid regions, is used as a botanical dietary supplement for weight loss. The increasing concerns on the quality and safety of Hoodia products call for the needs of more science-based information, as well as objective and efficient tools for

Pregnane glycosides from Hoodia gordonii.

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Hoodia gordonii is a 'weight loss' herb, which has gained popularity in the western countries as an appetite suppressant dietary supplement. Phytochemical study of its aerial parts led to isolation of seven pregnane glycosides (hoodigosides W-Z, hoodistanalosides A-B). Their structures were

Steroidal glycosides from Hoodia gordonii.

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Ten new C21-steroidal derivatives, namely gordonosides A-L (1-10) were isolated from a chloroform extract of the aerial parts of Hoodia gordonii, a plant widely used in the nutraceutical market as an ingredient of weight loss supplements. Compounds (2-10) are based on

Bioavailability, pharmacokinetics, and tissue distribution of the oxypregnane steroidal glycoside P57AS3 (P57) from Hoodia gordonii in mouse model.

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P57AS3 (P57), an oxypregnane steroidal glycoside, is known to be responsible for the appetite suppressing activity of HOODIA GORDONII, a dietary supplement used for weight loss. In this study, bioavailability, pharmacokinetics, and tissue distribution of P57 were determined in CD1 female mice after

In vitro transport of the steroidal glycoside P57 from Hoodia gordonii across excised porcine intestinal and buccal tissue.

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Hoodia gordonii was traditionally used by the Khoisan people as a thirst and appetite suppressant and is currently commercially available as a popular weight-loss supplement. The perceived active ingredient isolated from this plant is a steroidal glycoside named P57. This study aimed at

Genotoxicity of dried Hoodia parviflora aerial parts.

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Hoodia parviflora is being developed commercially for use in weight loss food and dietary supplement products. Its effects are ascribed to a number of glycosides that have been shown to be present in plant extracts from several Hoodia species, the best known of which is H. gordonii. H. parviflora

In vitro metabolic stability and intestinal transport of P57AS3 (P57) from Hoodia gordonii and its interaction with drug metabolizing enzymes.

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Hoodia gordonii, a succulent cactus-like plant growing in South Africa, has been used in traditional medicine for its appetite suppressant properties. Its use as a dietary supplement to promote weight loss has recently gained popularity. An oxypregnane steroidal glycoside P57AS3 (P57) is reported to

Hoodia gordonii: to eat, or not to eat.

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BACKGROUND Hoodia gordonii (family Apocynaceae) has become known globally for its claimed effect of appetite suppression. Despite a relatively large body of evidence of the plant׳s chemical make-up, peer-reviewed studies to provide scientific information on physiological effects of Hoodia gordonii

Subchronic and reproductive toxicity of whole dried Hoodia parviflora aerial parts in the rat.

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Hoodia parviflora is being developed commercially for use in weight loss food and dietary supplement products. As part of the safety assessment process for H. parviflora, a freeze dried powder preparation was tested in a 90-day oral toxicity study with reproductive/recovery component in rats. Groups

Appetite suppressing pregnane glycosides from the roots of Cynanchum auriculatum.

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In the search for plant alternatives to Hoodia gordonii containing P57, a pregnane glycoside with potential appetite suppressant effect, the roots of Cynanchum auriculatum were investigated. As a result, 15 pregnane glycosides including nine never previously reported were isolated. Their structures

Effects of Hoodia Parviflora on satiety, abdominal obesity and weight in a group of overweight subjects: a randomized, blinded, placebo-controlled trial.

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This study aimed to assess the effects of supplementation with H. Parviflora at 9 mg + 200 mg of fructo-oligosaccharides on weight loss, body composition, hydration and satiety parameters.A randomized blinded controlled trial was conducted in a sample of 30

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