hypertrophy/hypoxia

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Prospective Breast Cancer Biobanking

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A. Early detection of systemic relapses in breast cancer. WP 1. Analysis of primary tumor. Analysis of primary tumor and metastases (Pathology group). In this work package both DNA and RNA from the primary tumors of 125 high-risk (Luminal-B) patients will be analyzed by next-generation sequencing

Physical Exercise in Normobaric Hypoxia and Normoxia in Type 1 Diabetic Patients

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Hypoxia leads to HIF-1 production (hypoxia inducible factor 1) which regulates expression of many genes (eg. gene responsible for erythropoetin production). It also stimulates angiogenesis, muscle hypertrophy and glycolytic energy production by transactivating genes involved in extracellular glucose

A Preventive Treatment for Migrant Workers at High-risk of Covid-19

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This is a pragmatic, open-label, randomised study with 4 interventional and 1 control arms. Individuals will be recruited from migrant worker dormitories, and written informed consent taken prior to enrolment. Randomisation will be done by the level within the dormitory building and predetermined

Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia

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Factors Correlated With Obstructive Sleep Apnea in Children and Adolescents

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Obstructive Sleep Apnea (OSA) is a severe condition among sleep respiratory disorders, characterized by intermittent episodes of partial (hypopnea) or total (apnea) obstruction of the upper airways during sleep. These obstructive episodes result in hypoxemia and hypercapnia, changes in intrathoracic

RESIST! Blood-flow Restriction Resistance Training for Improving Insulin Sensitivity in Type 2 Diabetes

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Type 2 diabetes (T2D) is characterized by an increasing insensitivity of muscle, fat and liver cells to the hormone insulin. About 9% of the global population is affected by this condition and mortality risk is twice as high in individuals with diabetes compared to similar-aged people without

The Sensitivity of Traditional Chinese Medical Diagnostic Tools for Diabetic Retinopathy Diabetic retinopathy-a Pilot Study

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ECMO for Lung Transplantation in Cystic Fibrosis Patients

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Cystic fibrosis (CF) is the most common genetically inherited disease in the Caucasian population and damages multiple organ systems (i.e., upper and lower respiratory tract, pancreas, liver). Respiratory manifestations include reduction of mucus clearance, chronic pulmonary infections and

Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients.

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Background information Inflammatory bowel disease (IBD) fatigue is, with diarrhoea, the most common medical symptom in patients with active Crohn's disease (CD) and the second commonest complaint after arthralgia in CD patients in remission. The IBD priority-setting partnership between the James

Assessment of Potential Biomarkers in Women With Symptoms of Overactive Bladder and Pelvic Organ Prolapse

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Pelvic organ prolapse Pelvic organ prolapse (POP) is a clinical condition that, although it is not life-threatening, significantly affects patients' quality of life. POP affects more than 30% of females in the general population. Among those, the majority is free of symptoms and do not need any

Pulse Wave Velocity as a Predictor for Postoperative Cardiovascular Events

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Background: In 1894 William Osler, MD, said: "You are as old as your arteries." A number of recent studies have confirmed this prescient proclamation. Vascular rather than chronological age is the best predictor of adverse cardiovascular events and mortality from coronary insufficiency, ischemia,

A Study of Laryngoscopic Vision With the TotalTrack Device Versus Indirect Laryngoscopy

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The study hypothesis is that the new TTK device improves laryngoscopic visualization compared with direct laryngoscopy, thereby facilitating orotracheal intubation success. The null hypothesis is that the new TTK device does not improve visualization of the glottic structures, the intubation

Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy

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125 patients (78 men and 47 women) aged 18 - 65 years, with diagnosed resistant hypertension and moderate or severe OSA were included in the study, which was conducted in years 2014-2017 in the Department of Hypertension, Angiology and Internal Medicine and the Department of Pulmonology, Allergology

The Effects of Commercial Air Travel on Patients Suffering From Pulmonary Hypertension

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Pulmonary Hypertension (PH) is a progressive disease affecting the pulmonary vessels and leading to an increased pulmonary vascular resistance (PVR) and thus right heart strain. The result is an increase in mean pulmonary arterial pressure (mPAP) and with time dilation of the right heart chambers as

Feasibility and Predictive Accuracy of an In-Home Computer Controlled Mandibular Positioner in Identifying Favorable Candidates for Oral Appliance Therapy

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I. BACKGROUND AND SIGNIFICANCE Obstructive sleep apnea (OSA) is a common disease that carries significant risks for cardiovascular disease, mortality, and economic costs. Almost thirty years ago, initial population studies found the prevalence of OSA to be five to nine per cent of the adult

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