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Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising COVID-19 Infection- and Lung Injury Preventing Drug Better Than Recombinant Human ACE2

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This is a small pilot study investigating whether there is any efficacy signal that warrants a larger Phase 2B trial, or any harm that suggests that such a trial should not be done. It is expected to produce statistically significant results in the major endpoints. The investigator will examine all

Effectiveness of PENTABIOCEL in Clinical and Laboratory Recovery of Children With Celiac Disease

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Celiac disease (CD) is an intestinal inflammatory condition characterized by permanent intolerance to gluten, a protein complex present in wheat, barley, and rye, in genetically predisposed subjects. In the early phase of the disease, specific autoantibodies are generally present, which is relevant

Vorapaxar and Lower Extremity Bypass Grafts

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Peripheral artery disease (PAD) is characterized by atherosclerotic occlusive disease of the lower extremities. More than 8 million Americans and 200 million people globally have PAD. Recent data reveal a prevalence of 15% in the MEDICARE population. In populations at risk, patients with a history

Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis

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VI- Methods 1. Sample Selection After submission and approval of this project to the Research Ethics Committee (CEP) of the Piracicaba Dental School - UNICAMP, will be selected among the patients who seek spontaneously treatment in clinics Graduate FOP-UNICAMP (where also will be performed the

Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve Subjects

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This is a Phase IV, 48-week, open-label, pilot study in 30 ARV-naïve patients examining the safety, viral response, and tolerability of darunavir/cobicistat in combination with rilpivirine once daily for the treatment of HIV in treatment-naïve patients. Thirty subjects meeting the inclusion criteria

The Roles of Neutrophil Elastase in Lung Cancer

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Objectives 1. To demonstrate the presence of NE in vitro and the entrance into lung adenocarcinoma cells 2. To identify the intracellular mechanisms through which NE mediates its tumor proliferating effects 3. To verify the activation of NE and its related pathway component in clinical lung

Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

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Heart failure (HF) is a complex clinical syndrome and major public health problem claiming the lives of >500,000 per year. It is the leading Diagnosis Related Group (DRG) for hospital discharges in the US. There are approximately 1-3 million admissions annually for acute decompensated heart failure.

Allograft Fibrosis Following Pediatric Cardiac Transplantation

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There has been recent evidence that demonstrates a significant racial disparity in outcomes following pediatric heart transplantation.Differences in fibrosis or its regulation may offer an explanation to these differences.Just as the pathologic alterations of cardiac connective tissue in the

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