Indole / fetma

Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles

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BACKGROUND OF THE INVENTION It has been recognised that obesity is a disease process influenced by environmental factors in which the traditional weight loss methods of dieting and exercise need to be supplemented by therapeutic products (S. Parker, "Obesity: Trends and Treatments", Scrip Reports,

Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles

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BACKGROUND OF THE INVENTION It has been recognised that obesity is a disease process influenced by environmental factors in which the traditional weight loss methods of dieting and exercise need to be supplemented by therapeutic products (S. Parker, "Obesity: Trends and Treatments", Scrip Reports,

Composition for preventing or treating obesity, dyslipidemia, fatty liver or diabetes containing indole-3-carbinol derivative as active ingredient

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CROSS-REFERENCE TO RELATED APPLICATIONS This application is the U.S. national stage filing under 35 U.S.C. .sctn.371 of PCT International Application PCT/KR2011/010161, filed Dec. 27, 2011, which claims priority from Korean Patent Application 10-2011-0010585, filed Feb. 7, 2011. TECHNICAL FIELD The

4-(5-aminomethyl)-indole-1-ylmethyl)-benzamide derivatives and related compounds as opioid receptor antagonists for the treatment of obesity

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BACKGROUND Three types of opioid receptors, mu, kappa, and delta opioid receptors are generally reported. Recent evidence points to the interactions between receptor dimer combinations of mu, kappa and/or delta receptors (called heterodimers) as also contributing to opioid activity. Opioid receptors

Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders

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TECHNICAL FIELD This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain indole derivatives and their salts and solvates.

Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders

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TECHNICAL FIELD This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain indole derivatives and their salts and solvates.

Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders

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TECHNICAL FIELD This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain indole derivatives and their salts and solvates.

.alpha.-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents

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BACKGROUND OF THE INVENTION The present invention provides novel compounds. More particularly, the present invention provides novel .alpha.-amino-indole-3-acetic acids, tryptophans and their derivatives. The compounds are useful as anti-diabetic, anti-obesity and anti-atherosclerotic

Indole acetic acid derivatives and their use as pharmaceutical agents

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FIELD OF THE INVENTION This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation

Indole acetic acid derivatives and their use as pharmaceutical agents

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FIELD OF THE INVENTION This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation

Indole derivatives useful as glucagon receptor antagonists

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FIELD OF THE INVENTION The present invention is directed to indole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic

N-substituted indoles useful in the treatment of diabetes

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FIELD OF THE INVENTION The instant invention is concerned with N-substituted indoles having aryloxyalkanoic acid substituents, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, often

Indole derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating metabolic diseases containing same as active ingredient

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TECHNICAL FIELD The present invention relates to novel indole derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, or pharmaceutical composition for preventing or treating metabolic diseases such as obesity, diabetes, hyperlipidemia, or fatty liver comprising the

1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is substituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (X) which are useful for treating anxiety, depression and other CNS disorders in humans and animals. 2. Description of the Related Art U.S. Pat. No.

1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is substituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (X) which are useful for treating anxiety, depression and other CNS disorders in humans and animals. 2. Description of the Related Art U.S. Pat. No.

indole/fetma

Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles

Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles

Composition for preventing or treating obesity, dyslipidemia, fatty liver or diabetes containing indole-3-carbinol derivative as active ingredient

4-(5-aminomethyl)-indole-1-ylmethyl)-benzamide derivatives and related compounds as opioid receptor antagonists for the treatment of obesity

Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders

Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders

Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders

.alpha.-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents

Indole acetic acid derivatives and their use as pharmaceutical agents

Indole acetic acid derivatives and their use as pharmaceutical agents

Indole derivatives useful as glucagon receptor antagonists

N-substituted indoles useful in the treatment of diabetes

Indole derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating metabolic diseases containing same as active ingredient

1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position

1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position

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