infertility/protease

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Targeted expression of a cysteine protease (AdCP) in tapetum induces male sterility in Indian mustard, Brassica juncea.

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The development of male sterile plants is a prerequisite to developing hybrid varieties to harness the benefits of hybrid vigor in crops and enhancing crop productivity for sustainable agriculture. In plants, cysteine proteases have been known for their multifaceted roles during programmed cell

Binding of human secretory leukocyte protease inhibitor in uterine cervical mucus to immunoglobulins: pathophysiology in immunologic infertility and local immune defense.

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OBJECTIVE To identify an Fc receptor-like molecule in human cervical mucus. METHODS Controlled experimental laboratory study. METHODS Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima. METHODS Women undergoing treatment for infertility. METHODS Sodium dodecyl

Disruption of the ovarian serine protease (Osp) gene causes female sterility in Bombyx mori and Spodoptera litura.

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Precise regulation of oogenesis is crucial to female reproduction. 70% of pests belong to lepidopteran insect, so it would be interesting to explore the highly conserved genes involved in oogenesis that do not affect growth and development. This can provide potential target genes for

Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility.

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OBJECTIVE To study the incidence of single nucleotide polymorphisms in ubiquitin-specific protease 26 (USP26) gene and its involvement in idiopathic male infertility in China. METHODS Routine semen analysis was performed. Infertility factors such as immunological, infectious and biochemical

Evaluation of the levels of secretory leukocyte protease inhibitor in the cervical mucus of women with unexplained infertility.

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Secretory leukocyte protease inhibitor (SLPI) has specific effects on the immune system. SLPI is overexpressed in inflammation triggered by immune responses, which could have significant effects on the local immune responses in cervical mucosa. This over expression may be greater in

Immune mediators associated to male infertility in a mouse model of DNA immunization with the sperm protease proacrosin.

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The immune response has relevant physiological functions both in the male and female reproductive system, and must be tightly controlled to achieve a successful pregnancy. Several immune factors have been related to infertility, among them humoral and cellular immune responses triggered by sperm

Association of 370-371insACA, 494T>C, and 1423C>T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis.

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Whether the 370-371insACA, 494T>C, and 1423C>T haplotype in ubiquitin-specific protease 26 (USP26) gene is associated with male infertility is controversial. To clarify this issue, we conducted a meta-analysis based on the most recent studies. Eligible studies were screened by using PubMed and

Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism.

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Patients (n = 188) with non-obstructive azoospermia (NOA), and 17 fertile controls were screened for sequence changes in the ubiquitin specific protease (USP) 26 gene. Semen analysis, hormonal evaluation, and testicular biopsies were performed. DNA was extracted from whole blood. Denaturing

Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.

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OBJECTIVE The objective of the study was to assess antibodies against Chlamydia trachomatis heat shock proteins (HSP) in patients with tubal factor infertility (TFI), infertility controls (IFC), and fertile controls (FC). HSPs assist organisms in surviving caustic environments such as

Do alterations in follicular fluid proteases contribute to human infertility?

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OBJECTIVE Cathepsin L and ADAMTS-1 are known to play critical roles in follicular rupture, ovulation, and fertility in mice. Similar studies in humans are limited; however, both are known to increase during the periovulatory period. No studies have examined either protease in the follicular fluid of

Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.

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Deletions of USP9Y have been observed among infertile males with defective spermatogenesis. Therefore, the gene has been designated as a male infertility gene on the Y chromosome. However, it remains to be determined how male infertility results from deletions of this gene. In order to initiate an

Testes Proteases Expression and Hybrid Male Sterility Between Subspecies of Drosophila pseudoobscura.

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Hybrid male sterility (HMS) is a form of postmating postzygotic isolation among closely related species that can act as an effective barrier to gene flow. The Dobzhansky-Muller model provides a framework to explain how gene interactions can cause HMS between species. Genomics highlights the

Association between ubiquitin-specific protease USP26 polymorphism and male infertility in Chinese men.

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BACKGROUND Increased sperm ubiquitin was inversely associated with sperm count and motility. Ubiquitin-specific protease 26 (USP26), which is an X-linked gene, has been studied as a potential infertility gene. There are conflicting reports on whether variations in USP26 are associated with

Expression of a pathogen-induced cysteine protease (AdCP) in tapetum results in male sterility in transgenic tobacco.

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Usable male sterility systems have immense potential in developing hybrid varieties in crop plants, which can also be used as a biological safety containment to prevent horizontal transgene flow. Barnase-Barstar system developed earlier was the first approach to engineer male sterility in plants. In

Hybrid male sterility and genome-wide misexpression of male reproductive proteases.

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Hybrid male sterility is a common barrier to gene flow between species. Previous studies have posited a link between misregulation of spermatogenesis genes in interspecies hybrids and sterility. However, in the absence of fully fertile control hybrids, it is impossible to differentiate between

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