A composition comprising a) a compound of Formula (I), where R.sub.1, R.sub.2, and R.sub.3 are, each one and independently, hydrogen or a protector group, wherein said protector group may consist of an alkyl group, a cycloalkyl group, a heterocyclic cycloalkyl group, a hydroxyalkyl group, a halogenated alkyl group, an alkoxyalkyl group, an alkenyl group, an alkynyl group, an aryl group, a heterocyclic aryl group, an alkylaryl group, an ester group, a carbonate group, a carboxylic acid group, an aldehyde group, a ketone group, a urethane group, a silyl group, a sulfoxide group or a combination thereof, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are, each one and independently, hydrogen, hydroxyl or an --OR.sub.4 group, where R.sub.4 is a protector group according to the previous definition; and b) at least one chemotherapeutic agent, suitable for use in the treatment of Breast Cancer.

ENTRECHEM, S.L

ENTRECHEM, S.L.

Antitumor activity of multi-kinase inhibitors in triple negative breast cancer

Novel alkyl ketone compounds having potent cytotoxic activity are described as anti-tumor agents and are particularly effective against leukemia and breast tumor cells.

Parker Hughes Institute

Alkyl ketones as potent anti-cancer agents

Thiol-substituted synthetic steriod hormones or androgens having a testosterone ring system backbone are used to inhibit aromatase's catalyzed conversion of C.sub.19 androgens having a A.sup.4,3-ketone group to estrogens in the treatment of estrogen-dependent tumors, such as metastatic breast cancer in postmenopausal females.The compounds have the general formula: ##STR1## wherein R.sub.1 =a thiol, such as --SH or --CH.sub.2 SH, and R.sub.2 =OH or =O. The preferred synthetic hormones are 17.beta.-hydroxy-10.beta.-mercaptoestr-4-en-3-one, 19-mercaptoandrost-4-en-3,17-dione, and 10.beta.-mercaptoandrost-4-en-3,17-dione.

ketone/bröstcancer

Antitumor activity of multi-kinase inhibitors in triple negative breast cancer

Alkyl ketones as potent anti-cancer agents

Suicide inhibitors of aromatase

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