AqualiefTM 400 mg mucoadhesive oral tablet

Oral Diseases

AqualiefTM (Metis Healthcare s.r.l., Milano, Italy)

400 mg mucoadhesive oral tablet

placebo mucoadhesive oral tablet

Department of Biomedical, Surgical, and Dental Sciences, Istituto Stomatologico Italiano, Aesthetic Dentistry, School of Dentistry, University of Milan, Milan, Italy.

Carnosine Supplementation on Quantity/Quality of Oral Salivae.

PHoral: Effects of Carnosine Supplementation on Quantity/Quality of Oral Salivae in Healthy Volunteer and in Subjects Affected by Common Oral Pathologies.

Change of oral saliva production, unstimulated.

Change of oral saliva production, stimulated.

Michele Ciulla

Co-Principal Investigator

University of Milan

4 g by mouth, 3 times per day with regular meals for 14 days.

Cognitive Impairment

beta-alanine

placebo

Kinesiology Research Labs

Changes in Cognition During a 24-h Simulated Military Operation

Changes in Cognition During a 24-h Simulated Military Operation (SUSOP). Influence of β-alanine Supplementation and Markers of Classical Monocyte Recruitment

monitor frequency and severity of subjective symptoms related to a broad spectrum of conditions. The participant is presented with 21 symptoms. The participant is required to rate each symptom (e.g. fatigue, headache, Nausea, numbness/tingling etc. on a scale from 0 (Not Present) to 6 (Severe)

Throughput (TP) scores from each of seven cognitive assessments administered as part of a battery of tests via Automated Neuropsychological Assessment Metrics (ANAM) computer software. Tests include:
Simple reaction time
Code Substitution
Procedural Reaction Time
Mathematical processing
Matching to sample
Code substitution Delayed
Simple reaction time repeat

Surface expression of CD11b on classical monocytes and neutrophils

Surface expression of CCR2 on classical monocytes

Surface expression of CD11a on classical monocytes and neutrophils

Adam Wells

Assistant Professor

University of Central Florida

National Strength and Conditioning Foundation

Each participant will be given a daily oral dose 2 g of carnosine for 6 months

Each participant will be given a daily oral dose 2 g of placebo for 6 months

Peripheral Arterial Disease

Carnosine

Each participant will be given a daily oral dose 2 g of methycellulose powder for 6 months

Placebo

Monash Centre for Health Research and Implementation

Carnosine for Peripheral Vascular Disease

change in walking endurance (6-min walk test)

Barbora de Courten

Professor

Monash University

Monash Health

Amino acids parenteral (Levamin Nomo 10% ®) Group A with an initial doses of amino acids until reaching 3.5 g/kg/day during 28 days.For the study of renal function baseline urea, creatinine and BUN were measured within 24 h after birth in order to avoid any alteration cost by mother alter kidney function, afterwards the same markers were measured at the day 7, 14, 21 and 28. These markers were measure using orto-clinical diagnostic series 50-0278 USA.
The anthropometric measurements were assessed weekly by the same person to avoid bias (cephalic perimeter and height); weight was measured weekly using the same scale (SECA model 3741321009, Germany). All anthropometric and lab results were kept in a collection sheet.

Group B with an initial doses of 2.5 g/kg/day with daily increments of 0.5 g/kg/day until reaching 4 g/kg/day during 34 days.Weight, urea, creatinine and blood urea nitrogen (BUN) were measured weeklyFor the study of renal function baseline urea, creatinine and BUN were measured within 24 h after birth in order to avoid any alteration cost by mother alter kidney function, afterwards the same markers were measured at the day 7, 14, 21 and 28. These markers were measure using orto-clinical diagnostic series 50-0278 USA.
The anthropometric measurements were assessed weekly by the same person to avoid bias (cephalic perimeter and height); weight was measured weekly using the same scale (SECA model 3741321009, Germany). All anthropometric and lab results were kept in a collection sheet.

Abnormal Renal Function

Malnutrition

Group A we administered standard doses of amino acids was administered (3.5gr) the study of renal function baseline urea, creatinine and BUN were measured within 24 h after birth in order to avoid any alteration cost by mother alter kidney function, afterwards the same markers were measured at the day 7, 14, 21 and 28. These markers were measure using orto-clinical diagnostic series 50-0278 USA.
The anthropometric measurements were assessed weekly by the same person to avoid bias (cephalic perimeter and height); weight was measured weekly using the same scale (SECA model 3741321009, Germany). All anthropometric and lab results were kept in a collection sheet.

use amine acids parenteral 3.5g

Group B we administered high doses of amino acids was administered (4 gr) the study of renal function baseline urea, creatinine and BUN were measured within 24 h after birth in order to avoid any alteration cost by mother alter kidney function, afterwards the same markers were measured at the day 7, 14, 21 and 28. These markers were measure using orto-clinical diagnostic series 50-0278 USA.
The anthropometric measurements were assessed weekly by the same person to avoid bias (cephalic perimeter and height); weight was measured weekly using the same scale (SECA model 3741321009, Germany). All anthropometric and lab results were kept in a collection sheet.

use amine acids parenteral 4g

Instituto Mexicano del Seguro Social

Effects of High vs. Standard Protein Intake in Newborn Extreme Premature

Effects of High vs. Standard Protein Intake in the Weight Gain and Renal Function Security in Newborn Extreme Premature

Concerning renal function at 48h after birth and in the subsequent measurements in the 7, 14, 21, 28 day of life, the values of urea, creatinine and BUN, no statistical difference was detected. Also any values outside the reference values in the high dose amino acid group was detected (Table 4).

Guadalupe Gómez Rodríguez

Guadalupe Gómez Rodríguez Médico neonatologo

Coordinación de Investigación en Salud, Mexico

Universidad de Guanajuato

(1) temperature > 38oC or < 36oC; (2) pulse rate > 90 beats/min; (3) ventilation rate > 20 breaths/min or hyperventilation with a partial pressure of arterial carbon dioxide (PaCO2) < 32 mmHg; (4) white blood cell (WBC) count >1 2,000μL-1 or < 4000 μL-1 , or > 10% immature cells.

For the healthy control outpatients, possibilities of acute or past chronic diseases were excluded. Moreover, we made sure that the healthy control subjects had not been hospitalized or taken vitamin-based substitutive drugs in the last 12 months, and proved normal in physical checkups and lab examinations.

Sepsis

Amino Acids

Chinese PLA General Hospital

Amino Acids Expression Profiling of Patients With Sepsis

The survival time of patients more than 28 days is defined as survival. The survival time of patients less than 28 days is defined as death.

l histidine/inflammation

Carnosine Supplementation on Quantity/Quality of Oral Salivae.

Changes in Cognition During a 24-h Simulated Military Operation

Carnosine for Peripheral Vascular Disease

Effects of High vs. Standard Protein Intake in Newborn Extreme Premature

Amino Acids Expression Profiling of Patients With Sepsis

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