leiomyosarcoma/diarré

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Leiomyosarcoma of the colon: a case report and review of literature.

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Leiomyosarcoma of the colon, excluding that of the rectum, is extremely rare. We report a case of leiomyosarcoma of the ascending colon with a brief review of literature. The clinical manifestations in our case were typical: abdominal pain, diarrhea, anorexia, and a palpable tumor that was firm,

Multiple leiomyosarcoma of the stomach.

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Leiomyosarcoma is the second most common non epithelial malignant tumor of the stomach. It is almost always a single lesion. Multiple leiomyosarcomas of the stomach are extremely rare. To our knowledge only three cases have been reported so far. We present a 40 year old female with epigastric pain,

Leiomyosarcoma of the splenic vein: A case report.

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Leiomyosarcomas (LMSs) originating from the wall of blood vessels are aggressive and rare neoplasms. The current study describes a case of a 52-year-old man who presented with intermittent abdominal pain without weight loss or diarrhea. Computed tomography of the abdomen identified a 4-cm, solid,

A phase 2 study of alisertib (MLN8237) in recurrent or persistent uterine leiomyosarcoma: An NRG Oncology/Gynecologic Oncology Group study 0231D.

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OBJECTIVE This two-stage Phase II study assessed the activity of single agent alisertib in patients with recurrent/persistent uterine leiomyosarcoma (uLMS). METHODS Eligibility criteria included histologically-confirmed, recurrent or persistent uLMS, age≥18, 1-2 prior cytotoxic regimens, and RECIST

So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity.

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Inflammatory leiomyosarcoma, a rare entity first described in 1995, has been characterized by smooth muscle differentiation, a near-haploid karyotype, and a surprisingly good prognosis. The morphology is similar to that of conventional leiomyosarcoma admixed with a chronic inflammatory infiltrate.

Leiomyosarcoma of the colon exclusive of the rectum.

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Five cases of leiomyosarcoma of the colon are presented along with a review of the literature. In our cases the presenting symptoms and signs included abdominal pain, diarrhea, weight loss, blood in stools and abdominal mass. Anemia was present in four cases. Roentgenologically, an intraluminal

Sunitinib malate in the treatment of recurrent or persistent uterine leiomyosarcoma: a Gynecologic Oncology Group phase II study.

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OBJECTIVE New agents are needed for patients with metastatic uterine leiomyosarcoma who progress after treatment with doxorubicin or gemcitabine-docetaxel. Agents targeting tumor vasculature have potential for activity in leiomyosarcoma. We aimed to assess the activity of sunitinib in patients with

Idiopathic phlebosclerotic colitis: a rare entity of chronic ischemic colitis.

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Colonic wall thickening is frequently encountered in various conditions, from acute or chronic inflammatory disease to colorectal carcinoma. Colonic wall thickening may be accompanied by calcifications in mucinous adenocarcinoma of the colon, leiomyosarco-ma of the colon, schistosomiasis japonica,

Phase II study of docetaxel in advanced soft tissue sarcomas.

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Because of its unusual mechanism of action, docetaxel was selected for study in advanced soft tissue sarcomas of adults as part of a search for new active antisarcoma agents. Patients at least 18 years old with measurable histologically proven advanced nonosseous sarcomas were enrolled if they had

Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies.

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The majority of hematopoietic malignancies have aberrancies in the retinoblastoma (Rb) pathway. Loss in Rb function is, in most cases, a result of the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression. Flavopiridol, the first cdk

Primary neoplasms of the small bowel.

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The treatment of thirty-one malignant and eleven benign neoplasms of the small intestine is reported. The most common symptom was abdominal pain followed by vomiting, diarrhea, weight loss, constipation, and gastrointestinal bleeding. In four cases small bowel perforated. Intestinal obstruction

A multicenter Phase II study of bortezomib in recurrent or metastatic sarcomas.

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BACKGROUND Based on evidence of activity in preclinical and Phase I studies, the authors undertook a study of bortezomib, a reversible proteasome inhibitor, for patients with metastatic sarcomas. METHODS Two arms were opened, each using a Simon two-stage design. Arm A included patients with

Successful treatment of basaloid squamous cell carcinoma in the rectosigmoid colon: A case report and review of literature

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Background: Compared with colorectal adenocarcinoma, basaloid squamous cell carcinomas (BSCCs) arising in the colorectum are rare and have very poor prognosis. To date, only nine cases have been reported. Most BSCCs are extensively

An estrogen receptor-positive locally aggressive smooth muscle neoplasm of the transverse colon: A case report.

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BACKGROUND Extrauterine leiomyomas (LMs) in women are often positive for the estrogen receptor (ER); however, almost all extrauterine leiomyosarcomas (LMSs) are negative for ER. Invasive smooth muscle neoplasms (SMNs) of the gastrointestinal tract walls are very rare and those ER statuses have not

[Gastric stromal tumor with myxoid degeneration. Report of a case and review of the literature].

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BACKGROUND Gastrointestinal stromal tumors (GIST's) represent a heterogeneous group of neoplasms that have as their common histologic denominator an immature proliferation of epithelioid or spindle cells. Although originally believed to represent atypical variants of leiomyoma or leiomyosarcoma,

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