leukemia/protease

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Method of diagnosing large granular lymphocyte leukemia using alternative splice variants of serine proteases

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BACKGROUND OF THE INVENTION Granzymes are serine proteases present in secretory granules of cytolytic T cells and natural killer (NK) cells (Bleackley et al, 1988, Jenne, 1988). Granzyme B and A along with perforin have been implicated in cell-mediated cytotoxicity (Bleackley et al, 1988, Jenne,

Method of recovering cell antigen and preparation of feline leukemia vaccine therefrom

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BACKGROUND OF THE INVENTION The invention described herein was made in the course of work under a grant or award from the Department of Health, Education and Welfare. Viral-induced lymphoreticular neoplasms were first characterized in mice and rats, and later in chickens and turkeys. In 1964,

Method of recovering cell antigen and preparation of feline leukemia vaccine therefrom

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BACKGROUND OF THE INVENTION Viral-induced lymphoreticular neoplasms were first characterized in mice and rats, and later in chickens and turkeys. In 1964, viruses were also found to be associated with lymphoid malignancies of cats. The virus was named the Feline Leukemia Virus (FeLV). FeLV is

Inhibitors of Taspase1 protease activity

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TECHNICAL FIELD This invention relates to a novel protease. BACKGROUND MLL/HRX/ALL1 encodes a 3,969 amino acid nuclear protein bearing multiple conserved domains with assigned activities including: an N terminus with three AT-hook motifs that bind AT rich DNA segments (Zeleznik-Le et al., (1994)

Stable retrovirus and methods of use

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BACKGROUND OF THE INVENTION Safe and efficient gene delivery vectors are essential for the treatment of diseases (Friedmann & Roblin (1972) Science 175:949-955; Mulligan (1993) Science 260:926-932). Vector targeting, efficiency, and safety are of particular importance (Wickham (2003) Nat. Med.

Chimeric protein toxins for expression by therapeutic bacteria

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BACKGROUND Field of the Invention This invention is generally in the field of therapeutic delivery systems including bacteria, and systems and methods for providing chimeric proteins efficiently targeted to cancer cells. Description of the Prior Art Citation or identification of any reference

Antiviral ricin-like proteins

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FIELD OF THE INVENTION The invention relates to proteins having A and B chains of a ricin-like toxin, linked by a linker sequence which is specifically cleavable by a retroviral protease to release the active A chain. The invention also relates to a nucleic acid molecule encoding the protein and to

Anti-metalloprotease antibody for diagnosis and treatment of cancers

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INCORPORATION-BY-REFERENCE OF MATERIAL ELECTRONICALLY SUBMITTED Incorporated by reference in its entirety herein is a computer-readable nucleotide/amino acid sequence listing su currently herewith and identified as follows: One 8,709 Byte SCII (Text) filed named "726179_ST25.TXT," created Feb. 26,

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