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Thirty-six women with menorrhagia were treated with mefenamic acid during all menstrual periods for more than 1 year. These women had experienced objective and subjective benefit--menstrual blood loss was reduced and other menstrual symptoms improved during a preliminary 4-cycle double-blind
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OBJECTIVE
An open-label, extension clinical study was conducted to assess the safety of a novel, oral formulation of tranexamic acid (TA) in women with cyclic heavy menstrual bleeding.
METHODS
Eligible patients who completed either a three- or six-cycle double-blinded clinical trial of TA were
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OBJECTIVE
To review the pharmacology, pharmacokinetics, efficacy, and safety profile of an oral modified-release (MR) formulation of tranexamic acid.
METHODS
Literature was accessed through MEDLINE (1966-July 2012), Iowa Drug Information Service (1997-July 2012), and bibliographies of pertinent
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The purpose of this study was to examine patterns of use for oral contraceptive and desmopressin acetate nasal spray, both used in managing menorrhagia in adolescents with von Willebrand disease (vWD). Hospital records of adolescents with documented vWD and menorrhagia were reviewed retrospectively.
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OBJECTIVE
Treatment of menorrhagia with levonorgestrel intrauterine system (LNG IUS) and transcervical resection.
METHODS
An open, therapeutic, randomized study.
METHODS
Central county hospital specializing in hysteroscopy.
METHODS
Two parallel groups of 30 subjects each.
METHODS
Thirty patients had
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OBJECTIVE
To assess the efficacy and safety of ormeloxifene (centchroman) in the medical management of menorrhagia.
METHODS
Forty-two women with menorrhagia were recruited for the study. Ormeloxifene was given to each patient 60 mg twice a week for 3 months and then once a week for 1 month. Patients
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A double-blind, placebo-controlled crossover trial was undertaken to determine the efficacy of meclofenamate sodium in the treatment of menorrhagia. Twenty-nine patients who had a baseline menstrual blood loss greater than 60 ml received 2 months' each of meclofenamate sodium, 100 mg by mouth, three
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OBJECTIVE
A multicenter, long-term, open-label study was conducted to assess the safety and health-related quality of life (HRQoL) of an oral tranexamic acid (TA) formulation in women with cyclic heavy menstrual bleeding (HMB).
METHODS
Following a screening menstrual cycle, women with a history of
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OBJECTIVE
To evaluate the frequency of menorrhagia and endometriosis in female migraineurs compared to age-matched women without headache.
BACKGROUND
Migraine predominantly affects women of childbearing age and is often associated with the menstrual period, yet there is a paucity of data regarding
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Objective: To investigate the safety and efficacy of elagolix, an oral gonadotropin-releasing hormone antagonist, with hormonal add-back therapy for up to 12 months in women with heavy menstrual bleeding associated with uterine leiomyomas.
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BACKGROUND
Heavy menstrual bleeding is one of the most common reasons for referral of premenopausal women to a gynaecologist. Although medical therapy is generally first line, many women eventually will require further treatment. Endometrial ablation by hysteroscopic and more recent
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A 15-year-old African-American female presented with prolonged menstrual bleeding accompanied by a 1-week history of weakness, fatigue, dizziness, and bifrontal headaches. Her previous period was 5 weeks earlier, lasted 3 weeks, with heavy passage of clots. Family history is significant for bleeding
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Reactive thrombocytosis (secondary thrombocytosis) is frequent and typically moderate. We report a case of extreme thrombocytosis and leukocytosis secondary to an iron deficiency anemia. A 21-year-old woman is admitted in emergency department for acute headache. Biological assessment reveals a
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Reversible cerebral vasoconstriction syndrome (RCVS) manifests with a thunderclap headache and reversible vascular abnormalities. Red blood cell transfusions have not been well identified as a risk factor for RCVS. We report a rare case of acute brain injury resulting from RCVS after a packed red
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