migraine disorders/albumin

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Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway.

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OBJECTIVE To investigate urine albumin leakage as a marker of endothelial dysfunction in migraine patients. METHODS A population-based health study. METHODS 303 patients with migraine, 1009 patients with non-migraine headache and 5287 headache-free controls. RESULTS The association between urine

Toxicogenomics applied to cultures of human hepatocytes enabled an identification of novel petasites hybridus extracts for the treatment of migraine with improved hepatobiliary safety.

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Butterbur extracts (Petasites hybridus) are recommended for the prevention of migraine, but pharmacovigilance reports may be suggestive of rare hepatobiliary toxicity. To evaluate its hepatotoxic potential, a series of in vivo and in vitro studies were carried out. Essentially, there were no signs

A Comparative Study of Orally Delivered PBCA and ApoE Coupled BSA Nanoparticles for Brain Targeting of Sumatriptan Succinate in Therapeutic Management of Migraine.

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The present investigation aimed at brain targeting of sumatriptan succinate (SS) for its optimal therapeutic effect in migraine through nanoparticulate drug delivery system using poly (butyl cyanoacrylate) (PBCA) and bovine serum albumin linked with apolipoprotein E3 (BSA-ApoE). The study involved

Retinal plasma extravasation in animals but not in humans: implications for the pathophysiology of migraine.

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High-intensity electrical stimulation of the trigeminal ganglion is accompanied by mast cell degranulation, vasodilatation, increased endothelial permeability and leakage of albumin from postcapillary venules within the dura mater. Overall, the histological appearance suggests an evolving sterile

Injections of Intravenous Contrast for Computerized Tomography Scans Precipitate Migraines in Hereditary Hemorrhagic Telangiectasia Subjects at Risk of Paradoxical Emboli: Implications for Right-to-Left Shunt Risks.

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OBJECTIVE To evaluate if injection of intravenous particles may provoke migraines in subjects with right-to-left shunts due to pulmonary arteriovenous malformations (AVMs). BACKGROUND Migraine headaches commonly affect people with hereditary hemorrhagic telangiectasia (HHT), especially those with

Serum levels of androgens and migraine in postmenopausal women.

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Female hormones are thought to be of importance in the aetiology of migraine, which is more common in women than in men. Little attention has been paid to androgens. This study investigates the associations between migraine and serum levels of androgens in postmenopausal women not taking oestrogens.

Is ischemia associated with the formation of White matter lesions in migraine?

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White matter lesions (WMLs) are more common in migraine patients than in the normal population. Ischemia/hypoxia and oxidative stress are considered to play a role in WMLs formation. This study aimed to investigate ischemia-modified albumin (IMA), ferroxidase and thiol/disulfide

Is there a correlation between spreading depression, neurogenic inflammation, and nociception that might cause migraine headache?

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The time course of propagation of scotoma and blood flow changes during migraine aura parallels the phenomenon of cortical spreading depression (CSD). It was proposed that CSD generates a sterile neurogenic inflammation in the meninges, which may then lead to the activation or sensitization of

Evaluation of simple inflammatory blood parameters in patients with migraine.

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This study aimed to identify the serum neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), and C-reactive protein (CRP)/albumin (CAR) ratios among patients with diagnosis of migraine according to migraine subtypes (attack/attack-free

Imaging intracranial plasma extravasation in a migraine patient: a case report.

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Despite recent research advances, the origin of nociception in migraine headaches remains unclear and continues to be a topic of intense examination. Experiments using animal models of dural neurogenic plasma extravasation (DNPE) as an index of meningeal inflammation provided the basis for the

Population pharmacokinetic modeling and simulation of fremanezumab in healthy subjects and patients with migraine.

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AIMS

Fremanezumab is a fully humanized IgG₂ Δa/kappa monoclonal antibody specific for calcitonin gene-related peptide (CGRP) developed and approved for the preventive treatment of migraine in adults. The population pharmacokinetics (PK) of fremanezumab were

Absence of Mycoplasma-specific DNA sequence in brain, blood and CSF of patients with multiple sclerosis (MS): a study by PCR and real-time PCR.

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Mycoplasmas are the smallest of the known self-replicating organisms. They lack cell walls and are associated with numerous diseases in humans and animals. We are exploring the possibility that infection by Mycoplasma may induce the inflammatory demyelinating disease of the central nervous system

A fluorescence-based method to assess plasma protein extravasation in rat dura mater using confocal laser scanning microscopy.

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We describe a nonradioactive, fluorescence-based method to assess plasma protein extravasation (PPE) in rat dura mater using confocal laser scanning microscopy (CLSM). Unilateral PPE can be induced by electrical stimulation of the ipsilateral trigeminal ganglion (TG) and is widely used as an

A fluorescence-based method for assessing dural protein extravasation induced by trigeminal ganglion stimulation.

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Neurogenic dural inflammation has been proposed as a source of pain during migraine. Unilateral electrical stimulation of the trigeminal ganglion causes the ipsilateral release of inflammatory neuropeptides and subsequent dural plasma protein extravasation, a component of neurogenic inflammation. We

Hormone allergy.

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BACKGROUND Estrogen and progesterone have been associated in women with symptoms that include asthma, migraine, dermatitis and pain. OBJECTIVE We suggest a connection between symptoms associated with hormone changes to a hormone antibody response. METHODS For IgG, IgM and IgE antibodies to

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