Patients submitted a Bone marrow transplantation with the busulfan chemotherapy in the conditioning. Saliva monitoring

Patients submitted a Bone marrow transplantation without busulfan chemotherapy in the conditioning.Saliva monitoring

Bone Marrow Disease

The first objective of this project is to verify the feasibility of using the analysis of salivary concentration of BU during individual adjustments of this drug in the period that precedes HSCT

Saliva monitoring

Busulfan Concentration in Saliva and Plasma, and Its Relationship With Salivary Changes and Mucositis in the Digestive Tract of Patients Submitted to Hematopoietic Stem Cell Transplantation

An analysis will be performed of the Bu concentration in saliva and in blood, as well as the salivary dosage of total proteins, albumin, amylase, antioxidant enzymes

Fernanda de Paula Eduardo

Dentist

Hospital Israelita Albert Einstein

Standard treatment followed in the regional cancer center for prevention and treatment of oral mucositis during chemo radiotherapy of cancers. 20% Benzocaine 15grms. twice daily for the entire treatment period

Ascorbic acid oral supplementation 1g four times daily for the entire treatment period of 30 days and after treatment by tapering the dose of the drug to half for another month. The drug has to be started 2 days prior to initiation of treatment of cancer.
Subdivided into 2 groups , 30 patients in each : sub group 1: only radiotherapy patients, subgroup 2 includes concurrent chemo-radiotherapy patients.

Oral Mucositis

Ascorbic acid oral supplementation 1g four times daily for the entire treatment period and 30 days after treatment by tapering the dose of the drug to half. The drug has to be started 2 days prior to initiation of treatment of cancer.

Ascorbic Acid

Zinc acetate 50mg tablets orally twice daily for entire period of cancer treatment

Zinc acetate

MNJ institute of oncology & regional cancer center

Effect of Oral Vitamin C in Assessing the Severity of Oral Mucositis in Chemoradiation of Head and Neck Cancers

Effect of Ascorbic Acid Oral Supplementation in Assessing the Severity of Oral Mucositis in Chemo-radiation Therapy of Head and Neck Cancers.

oral mucositis severity would be measured weekly in all the patients during the entire treatment of radiotherapy/chemotherapy

NALLAN CHAITANYA

Associate Professor, department of oral medicine and radiology, panineeya institute of dental sciences

Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Saveetha University

MNJ Institute of Oncology & Regional cancer Center

Mucositis

Hematopoietic Stem Cell Transplantation

Drug: selenium tablet Oral selenium 1 Tab bid from day -6/-7 until discharge

Oral selenium

Drug: Placebo Oral placebo 1 Tab bid from day -6/-7 until discharge

Oral placebo

Hematology-Oncology & SCT Research Center

Oral Selenium Therapy for the Prevention of Mucositis

A Randomized Double Blinded Placebo Controlled Oral Selenium Therapy for the Prevention of Mucositis in Patients Undergoing High Dose Chemotherapy With Hematopoietic Stem Cell Transplantation

The effect of oral selenium on prevention of mucositis in patients undergoing bone marrow transplantation

mucositis/glutation

Busulfan Concentration in Saliva and Plasma, and Its Relationship With Salivary Changes and Mucositis in the Digestive Tract of Patients Submitted to Hematopoietic Stem Cell Transplantation

Effect of Oral Vitamin C in Assessing the Severity of Oral Mucositis in Chemoradiation of Head and Neck Cancers

Oral Selenium Therapy for the Prevention of Mucositis

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