Insertion of the etonogestrel contraceptive implant subdermally over the non-dominant scapula

Contraception

Insertion of the contraceptive implant at an alternative insertion site located over the scapula

Etonogestrel implant

University of Colorado Denver

Shoulder Contraceptive Implant Study

Pilot Study of Etonogestrel Contraceptive Implant Insertion at an Alternative Subdermal Scapular Site

Serum etonogestrel concentration curves measured over the first year of implant use

Local and systematic side effects associated with etonogestrel contraceptive implant use

University of Colorado, Denver

Patients with proven neuromuscular disorders known to be potentially associated with significant diaphragmatic weakness, e. g. ALS, myotonic dystrophy type 1, limb-girdle muscular dystrophy, Duchenne and Becker muscular dystrophy. Patients already receiving home ventilatory support will not be included in the study.

Patient with proven obstructive sleep apnea syndrome prior to CPAP initiation.

Patients with sleep disorders other than sleep-related breathing disorders, e. g. narcolepsy, hypersomnia, parasomnia or sleep-related movement disorders.

Neuromuscular Disorders

All patients answer selected questionnaires on sleep-related symptoms, sleep quality, daytime performance, and health-related quality of life.

patient-filled questionnaires

Measurement of forced vital capacity, maximum inspiratory pressure and maximum expiratory pressure

spiromanometry

University Hospital Münster, Department of Sleep Medicine and Neuromuscular Disorders

Bethanien Hospital

Screening Questionnaire for Respiratory Muscle Weakness and Sleep-disordered Breathing in Neuromuscular Disorders

Validation of a German Language Screening Questionnaire for Symptoms of Respiratory Muscle Weakness and Sleep-disordered Breathing in Patients With Neuromuscular Disorders

Matthias Boentert

MD, Senior Consultant in Neurology and Sleep Medicine

Westfälische Wilhelms-Universität Münster

Melatonin 10mg capsule(high dose arm), oral, once at night, given for 28 days

Sugar Pill, one capsule, once at night, 28 days

Melatonin 3mg capsule (low dose arm), once, at night, 28 days

Post-concussion Syndrome

Post-concussive Symptoms

Traumatic Brain Injury

Concussion

Children

Melatonin 10mg or 3mg capsule, one will be given at night, for 28 days

Melatonin

Sugar pill will be given, one capsule, once at night, for 28 days

Sugar pill

Alberta Children's Hospital

PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin

PLAY GAME: Post-concussion Syndrome Affecting Youth: GABAergic Effects of Melatonin. A Randomized Double-blind Placebo-controlled Trial of MELATONIN

The PCSI is a standardized questionnaire of 26 symptoms provides an overall rating of Post concussion symptoms. It has four specific domains: physical (including headaches), cognitive, emotional (including mood) and fatigue and high level of internal consistency, alpha=0.92. Parent and youth PCSI scores correlate. Low symptom rates are found in normative samples. The version for youth will also be recorded (PCSI-Y). Change in PCSI scores allows us to account for baseline variability and gender.

Parent and child rating of functional impairment will be obtained using the 50-item Child Health Questionnaire, parent CHQ-Parent Form (PF)50 and child, CHQ-Child Form (CF)87. The reliability and validity is established in TBI and PCS.

BASC-2 is a standardized parent report measure of child behavior consisting of 150 items. It provides an indication of internalizing and externalizing behaviour (e.g., anxiety, depression). Items are rated using true-false, or a 4-point ordinal scale.
The internal consistency for the composite subscales range from .87 to .96 and test-retest reliability is high, ranging from .81 to .96 (10-20 minutes) (

Dr. Karen Barlow

Principal Investigator

University of Calgary

Children's Hospital of Eastern Ontario

2 x 10mg capsules of melatonin, single dose. Blood sampling and physiological measures (blood pressure, ECG, oxygen saturation) every 30 mins for 6 hours.

3 x 10mg capsules of melatonin, single dose. Blood sampling and physiological measures (blood pressure, ECG, oxygen saturation) every 30 mins for 6 hours.

5 x 10mg capsules of melatonin, single dose. Blood sampling and physiological measures (blood pressure, ECG, oxygen saturation) every 30 mins for 6 hours.

10 x 10mg capsules of melatonin, single dose. Blood sampling and physiological measures (blood pressure, ECG, oxygen saturation) every 30 mins for 6 hours.

Sepsis

University of Aberdeen

Melatonin in Healthy Volunteers

A Dose Escalation Study of Melatonin in Healthy Volunteers as a Potential Treatment for Sepsis

Adverse events : nausea, vomiting, diarrhoea, itching, headache, drowsiness and any other symptoms for 6h immediately after dosing and again after 1 week. Sleeping patterns will also be assessed after 1 week.
Altered heart rate, oxygen saturation, ECG, blood pressure.
Changes in biochemistry (sodium , potassium, urea, AST, creatinine, glucose) or haematology (WBC and differential counts).
All events will be graded according to prospectively defined criteria.

Neuromuscular Disease

Patients will be referred for evaluation for NNIV is indicated in patients with diurnal Pa,CO2 >6.0 Pa; and 2) nocturnal Sa,O2 <88% for 5 consecutive min. End tidal CO2 representing equivalent values will be referred for NNIV

Evaluation for Nocturnal non invasive ventilation

Novel Methods of Ambulatory Physiologic Monitoring in Patients With Neuromuscular Disease

muscular dystrophies/huvudvärk

Shoulder Contraceptive Implant Study

Screening Questionnaire for Respiratory Muscle Weakness and Sleep-disordered Breathing in Neuromuscular Disorders

PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin

Melatonin in Healthy Volunteers

Home Sleep Testing in Neuromuscular Disease Patients

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