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13 resultat
1,3-diaryl cyclopentanes and derivatives thereof as PAF antagonists
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BACKGROUND OF THE INVENTION
Platelet-activating factor (PAF) has recently been identified as an acetyl glyceryl ether phosphorylcholine (AGEPC), i.e., 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (Hanahan D. J. et al., J. Biol. Chem. 255:5514, 1980). Even before its chemical
1,3-diaryl cyclopentanes and derivatives thereof as PAF antagonists
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BACKGROUND OF THE INVENTION
Platelet-activating factor (PAF) has recently been identified as an acetyl glyceryl ether phosphorylcholine (AGEPC), i.e., 1-0-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorycholine (Hanahan D. J., et al., J. Biol. Chem. 255:5514, 1980). Even before its chemical
Chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Chimeric and humanized anti-histone antibodies
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FIELD OF THE INVENTION
The invention relates to compositions and methods of use of anti-histone antibodies or antigen-binding fragments thereof. In particular embodiments, the antibodies bind to human histones H2B, H3 or H4. The anti-histone antibodies are of use for diagnosis and/or therapy of a
Nucleic acids encoding chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Methods for treating thrombosis using chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Methods for treating sepsis using chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Methods for treating ischemic stroke using chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Methods of treating rapidly progressive glomerulonephritis using chimeric and humanized anti-histone H4 antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1 SL.txt and is 71,342 bytes in size.
FIELD OF THE
A1 adenosine receptor antagonists
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FIELD OF THE INVENTION
The present invention relates to compounds that are A.sub.1 adenosine receptor antagonists, and to their use in treating mammals for various disease states, such as asthma, diabetes, cardiac disorders, degenerative disorders of the central nervous system, and disease states
Methods for treatment of nephrotic syndrome and related conditions
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FIELD OF THE DISCLOSURE
The present disclosure is directed to methods for the treatment and prevention of nephrotic syndrome and conditions related thereto, such as, but not limited to, proteinuria and edema.
BACKGROUND
Nephrotic syndrome (NS) is a general term that refers to the loss of protein in
Methods for treatment of nephrotic syndrome and related conditions
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FIELD OF THE DISCLOSURE
The present disclosure is directed to methods for the treatment and prevention of nephrotic syndrome and conditions related thereto, such as, but not limited to, proteinuria and edema.
BACKGROUND
Nephrotic syndrome (NS) is a general term that refers to the loss of protein in
Pyrazolopyridine compounds which have useful pharmaceutical utility
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The present invention relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof.
More particularly, it relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof, which are adenosine antagonists and posses various pharmaceutical actions
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