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FIELD OF THE INVENTION
The present invention relates to, inter alia, novel trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds, their physiologically acceptable salts and prodrugs, which modulate the activity of protein phosphatases and uses thereof. The invention also relates to the
FIELD OF THE INVENTION
This invention relates to the field of protein tyrosine phosphatase inhibition.
BACKGROUND OF THE INVENTION
This invention relates to a novel class of phosphonic acid derivatives that are inhibitors of PTP-1B.
Reversible protein tyrosine phosphorylation, coordinated by the
FIELD OF THE INVENTION
This invention relates to the field of protein tyrosine phosphatase inhibition.
BACKGROUND OF THE INVENTION
This invention relates to a novel class of phosphonic acid derivatives that are inhibitors of PTP-1B.
Reversible protein tyrosine phosphorylation, coordinated by the
TECHNICAL FIELD OF THE INVENTION
The invention relates to the regulation of human protein phosphatase IIC-like enzyme activity for therapeutic effects.
BACKGROUND OF THE INVENTION
The protein phosphorylation/dephosphorylation cycle is one of the major regulatory mechanisms employed by eukaryotic
This application is U.S. National Phase of International Application PCT/AU2007/000391, filed Mar. 29, 2007 designating the U.S., and published in English as WO 2007/109851 on Oct. 4, 2007, which claims priority to U.S. Provisional Application No. 60/787,240 filed Mar. 29, 2006.
FIELD OF THE
BACKGROUND OF THE INVENTION
The present invention relates to assays and methods for identifying or for testing agents which are modulators of a serine-threonine phosphatase PPM1E and can be used for treating and/or preventing neurodegenerative disorders.
The present invention relates to methods of
FIELD OF THE INVENTION
The invention relates to the use of inhibitors of calcineurin to prevent glutamate neurotoxicity.
BACKGROUND OF THE INVENTION
Nitric oxide (NO) has been demonstrated to mediate neuronal relaxation of intestines (Bult (1990) Nature, 345:346-347; Gillespie (1989) Br. J.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims priority of Korean Patent Applications Nos. KR 10-2015-0100430, filed Jul. 15, 2015 and KR 10-2015-0100481, filed Jul. 15, 2015, the contents of each of which are hereby incorporated by reference into the application.
REFERENCE TO A
CROSS-REFERENCE TO A RELATED APPLICATION
The present application is a National Stage (371) of International Application PCT/JP02/11365, filed on Oct. 31, 2002, which claims priority to Japanese Patent Application No. JP 2001-335833, filed on Oct. 31, 2001.
TECHNICAL FIELD
The present invention
BACKGROUND OF THE INVENTION
The present invention relates to the discovery of protein--protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Huntington's Disease, Parkinson's Disease, dementia and Alzheimer's Disease (AD). Thus, the present invention is
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to substituted carboxylic acids and more specifically to such compounds that are useful in the treatment of diabetes. More specifically, it relates to such compounds that are capable of inhibiting Protein tyrosine
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to substituted carboxylic acids and more specifically to such compounds that are useful in the treatment of syndrome X (consisting of such abnormalities as obesity, dyslipidemia, hypercoagulation, hypertension, insulin
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to phenyl substituted carboxylic acids and more specifically to such compounds that are useful in the treatment of syndrome X (consisting of such abnormalities as obesity, dyslipidemia, hypercoagulation, hypertension,
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to phenyl substituted carboxylic acids and more specifically to such compounds that are useful in the treatment of syndrome X (consisting of such abnormalities as obesity, dyslipidemia, hypercoagulation, hypertension,
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to substituted carboxylic acids and more specifically to such compounds that are useful in the treatment of syndrome X (consisting of such abnormalities as obesity, dyslipidemia, hypercoagulation, hypertension, insulin