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Randomised trial of intranasal nicotine and postoperative pain, nausea and vomiting in non-smoking women.
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BACKGROUND
The primary aim of this study is to test the hypothesis that intranasal nicotine reduces postoperative opioid use among non-smoking women. The second aim is to determine the effects of intranasal nicotine on the incidence of postoperative nausea and vomiting (PONV).
METHODS
In this
Nicotine patch for the prevention of postoperative nausea and vomiting: a prospective randomised trial.
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OBJECTIVE
It has been demonstrated that smoking significantly reduces postoperative nausea and vomiting (PONV). However, there are approximately 4000 substances in cigarette smoke that can be responsible for this effect. To demonstrate whether nicotine is the substance with antiemetic effects we
Inhibition by morphine and morphine-like drugs of nicotine-induced emesis in cats.
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The effect of morphine, methadone and pethidine injected into the cerebral ventricle of the unanesthetized cat upon emesis produced by nicotine induced similarly was investigated. Morphine and morphine-like drugs depress or abolish the emetic effect of nicotine. The inhibitory effect of morphine,
Enantiospecific inhibition of emesis induced by nicotine in the house musk shrew (Suncus murinus) by the neurokinin1 (NK1) receptor antagonist CP-99,994.
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Effects of the NK1 receptor antagonist CP-99,994 on nicotine-induced emesis were examined in Suncus murinus. CP-99,994 (3 and 10 mg/kg i.p.) attenuated emesis to (-)nicotine (4 mg/kg s.c.). CP-100,263 (3 and 10 mg/kg i.p.), the enantiomer of CP-99,994 with 1000 fold lower affinity for the NK1
Maternal alcohol and tobacco use and nausea and vomiting during pregnancy: relation to infant birthweight.
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A recent report has documented a decreased probability of nausea and vomiting during pregnancy (NVP) in women who were simultaneously both regular drinkers and smokers, especially if these habits existed before pregnancy. Maternal smoking and drinking have both been linked with decreased infant
Selective effect of ethanol on norepinephrine- and nicotine-induced emesis in cats.
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The effect of acute ethanol administration into the cerebral ventricles of the unanesthetized cat upon emesis produced by norepinephrine and nicotine injected similarly was investigated. Ethanol inhibited the norepinephrine- and nicotine-induced emesis. The inhibitory effect of ethanol occurred
Maternal alcohol and tobacco consumption and their association with nausea and vomiting during pregnancy.
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Nausea and vomiting during pregnancy (NVP) has been associated with favorable pregnancy outcome, though little is known about factors influencing its occurrence. In this study, information on NVP in 210 patients at a west coast health maintenance organization was obtained. Smoking and alcohol
Transcutaneous nicotine does not prevent postoperative nausea and vomiting: a randomized controlled trial.
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OBJECTIVE
There is empirical evidence that smokers are less likely to suffer from postoperative nausea and vomiting (PONV). We sought to investigate whether transcutaneus nicotine prevents PONV.
METHODS
Non-smokers receiving general anaesthesia for surgery were randomly allocated to Nicotinell Patch
The association of reproductive history, demographic factors, and alcohol and tobacco consumption with the risk of developing nausea and vomiting in early pregnancy.
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The role of maternal risk factors in the development of nausea and vomiting in pregnancy was studied in a historical cohort of 825 women who gave birth at the University of California (Los Angeles) Medical Center during a one-year period (April 1983-March 1984). The roles of demographic factors,
Opposite effects of ethanol and nitrendipine on nicotine-induced emesis and convulsions.
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The effects of ICV injections were investigated in unanesthetized cats of ethanol alone and in combination with the dihydropyridine calcium antagonist, nitrendipine, on emesis and the convulsions produced by nicotine, which was similarly injected by the ICV route. In the first series of experiments,
Further studies on nicotine-induced emesis: nicotinic mediation in area postrema.
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In unanesthetized cats the emetic action of an injection of nicotine into the cerebral ventricle through chronically implanted cannulae was investigated. Nicotine injected in doses of 0.02-1.0 mg produced dose-dependent vomiting, which was abolished after ablation of the area postrema. However,
The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew).
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Considerable evidence implicates the endocannabinoid system as a neuromodulator of nausea and vomiting. The action of anandamide (AEA) can be prolonged by inhibiting its degradation, through the use of URB597 (URB), a Fatty Acid Amide Hydrolase (FAAH) enzyme inhibitor. Here we present evidence that
[Central mechanisms of vomiting: the effect of histamine, 5-hydroxytryptamine, noradrenaline, nicotine and morphine].
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Nicotine gum chewing: a novel strategy to shorten duration of postoperative ileus via vagus nerve activation.
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Postoperative ileus (POI) is a transit cessation of bowel motility after surgery. Substantial evidences suggest that gum chewing accelerate the recovery of bowel motility after surgery. Perioperative nicotine administration reduces postoperative opioid use and prevents postoperative nausea and
Antidepressant effect of transdermal nicotine patches in nonsmoking patients with major depression.
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BACKGROUND
A high frequency of cigarette smoking has been reported among individuals with major depression. In a previous study, transdermal nicotine produced short-term improvement in the mood of depressed patients. This study was undertaken to determine the effects of 4 days' administration of
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