The child ́s weight and height will be registered. The children's urine will be tested for infection with a dipstick urinalysis.
The child will be asked to perform home recordings for seven days consisting of measurements of diaper weight and first morning voided volume and a two-day frequency-volume chart.

Nocturnal Enuresis

The child will collect:
Urine at bedtime on a wet and a dry night.
Urine during a wet night through a collecting device.
First morning voided volume following both a wet and a dry night.

Urine collection through a collecting device (Uridom®) for maximum 1 week

Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital

Biomarkers in Urine for Children With Monosymptomatic Nocturnal Enuresis and Nocturnal Polyuria

By using mass spectrometry (proteomics). For all children, any proteins related to nocturnal polyuria will be detected.

By enzyme-linked immunosorbent assay (ELISA).

A urine volume for the "dry night" (first morning voided volume) and "wet night" (nighttime urine production + first morning voided volume) will be calculated.

A level for the "dry night" and "wet night" will be calculated.

By freezing-point depression. A level for the "dry night" and "wet night" will be calculated.

University of Aarhus

20 boys will be included for urine collection.

Drug1. name:desmopressin form:tablet dosage:2-4mg frequency:qn duration:3 months Drug2 name:Suoquan mixture form:liquid dosage:10ml/time frequence:bid duration:3 months

name:desmopressin form:tablet dosage:2-4mg frequency:qn duration:3 months

Monosymptomatic Nocturnal Enuresis

Desmopressin

Suoquan

Children's hospital of Fudan university

Study on Chinese and Western Medicine in MNE Children

Study on the Therapeutic Schedule and Mechanism of Suoquan Mixture Combined With Desmopressin to Children's Monosymptomatic Enuresis

If Suoquan mixture plus desmopressin could reduce the relapse rate of MNE

Hong Xu，MD.PhD

chief physician

Children's Hospital of Fudan University

group1 desmopressin group2 desmopressin plus Suoquan mixture

At 4 visits capillary blood sampling for copeptin measurement will be performed with each child.

blood sampling

University Hospital Basel

Copeptin for Prediction of Treatment Response in Children With Monosymptomatic Nocturnal Enuresis (MEN).

University Hospital, Basel, Switzerland

University Children's Hospital Basel

A Rapid Maxillary Expander will be fitted and the palate will be expanded approximately 5mm.

A Sham appliance is fitted and activated for 10-14 days. The patients in this group will after it has been revealed they were randomized into the placebo group have a true Rapid Maxillary Expander fitted and the palate will be expanded approximately 5 mm.

The Rapid Maxillary Expander will over 10-14 days create a palatal expansion of about 5mm.

Rapid Maxillary Expansion

The Placebo Appliance looks exactly like the Rapid maxillary Expander but the expansion screw does not work. When the expansion screw is activated it does not create a palatal expansion.

Placebo Appliance

Folktandvården Uppsala län

Nocturnal Enuresis and Rapid Maxillary Expansion

Nocturnal Enuresis and Rapid Maxillary Expansion - Long Term Effect, Prognostic Factors, Quality of Life and Sleep Quality

The validated quality of life questionnaire Paediatric Incontinence Questionnaire

The validated quality of life questionnaire OSA 18

Polygraphic sleep recordings will be carried out at 3 time points during the study

Ingrid Jönson Ring

Uppsala University Hospital

Örebro County Council

Uppsala County Council, Sweden

Patients receiving Desmopressin lyophilisate (Melt).

Monosymptomatic Nocturnal Enuresis.

Patient receives Desmopressin lyophilisate (Melt).

Desmopressin lyophilisate (Melt)

Ghent University Hospital

Desmopressin Melt: Impact on Sleep and Daytime Functioning

Desmopressin Melt: Impact on Sleep and Daytime Functioning? A Prospective Study.

Forced diuresis and 24h concentration profile with measurement of Na, K, creatinin, osmolality

Wechsler Intelligence Scale for Children-Third Edition (WISC-III) short version

Child Behavior Checklist - CBCL (parents)

"Vragenlijst voor Gedragsproblemen bij Kinderen" (VvGK): questionnaire to screen for ADHD and behavioral disorders (parents, teacher)

Behavior Rating Inventory of Executive Function (BRIEF): questionnaire to assess executive functions) (parents, teacher)

Pediatric Incontinence Questionniare (PinQ): questionnaire to measure health related quality of life, specific enuresis (parents + child)

Pediatric Quality of Life Inventory (PedsQL): questionnaire to measure health related quality of life (parents + child)

Kiddie Schedule for Affective Disorders and Schizofrenia (K-SADS): diagnostic interview if CBCL/TRF is (sub)clinical (parents + child)

Cambridge Neuropsychological Test Automated Battery (CANTAB) (child)

IQ: WISC-III subtest Digit Span - children are orally given sequences of numbers and asked to repeat them, either as heard or in reverse order. (child)

Test of Everyday Attention for Children (TEA-ch): subtest Secret code + Score DT (sustained attention task) (child)

"Competentiebelevingsschaal voor Kinderen/Adolescenten" (CBSK/CBSA): questionnaire to measure self-esteem in children or adolescents OR The pictorial scale of perceived competence and social acceptance for young children. (child)

Swanson, Kotkin, Agler, Mylnn, and Pelham (SKAMP) Rating Scale: observation scale (teacher)

School results: copy of schoolreport (+median) (teacher)

Pediatric Sleep Questionnaire (questionnaire to assess the quality of sleep) (parents)

Children's Sleep Habits Questionnaire (CSHQ) (parents)

Polysomnography (overnight hospitalization) (child)

University Hospital, Ghent

Ferring Pharmaceuticals

Primary Nocturnal Enuresis

desmopressin 120 mcg melt tablet; 120 mcg, 240 mcg or 360 mcg administered once daily before bedtime

desmopressin

placebo melt tablet; 1 to 3 placebo melt tablets administered once daily before bedtime

placebo

IWK Health Centre

The Male Health Centres

Cambridge Family Medical Centre

Private Clinic

Quest Clinical Trials Inc.

Markham Place Med Centre

The Kids Clinic

Desmopressin Response in the Young

Desmopressin Response in the Young: A Double-blind, Randomised, Placebo-controlled, Dose-titration Study With Three Different Doses (120 Mcg, 240 Mcg and 360 Mcg) of Desmopressin Administered as a New Melt Tablet in Children and Adolescents With Primary Nocturnal Enuresis (PNE).