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PERSEUS-PS Randomized Controlled Trial

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BACKGROUND Since 2000, resuscitation guidelines remain uniform across all cardiac arrest patients, focusing on the delivery of chest compressions to a standardized rate and depth and algorithmic vasopressor dosing. Although the concept of goal-directed hemodynamic optimization as a treatment

Analysis of Mortality of Critically Ill Patients With COVID-19

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Introduction The World Health Organization (WHO) has recently declared SARS-CoV-2 (COVID-19) disease as an international alarm public health emergency. This ongoing pandemic of COVID-19 disease is devastating, despite widespread implementation of control measures, which is creating a challenge for

"The Effect of Stellate Ganglion Block in Severe Brain Injury"

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Hypothesis Stellate ganglion blockade in patients with moderate and severe brain damage: 1. Increases the diameter of the brain arteries and blood flow through the brain 2. Do not interfere with intracranial pressure 3. Reduces aseptic inflammatory reaction of the damaged brains measured by IL-6 and

Effect of Vasopressin vs Norepinephrine on Pulmonary Oxygenation and Lung Mechanics in Patients With Hypertension Therapy During One-lung Ventilation : Preliminary Study

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Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock

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GENERAL OBJECTIVE To demonstrate that a CRT-targeted FR is associated with less positive fluid balances, organ dysfunctions, and similar improvement of markers of tissue hypoperfusion and hypoxia, when compared to a lactate- targeted FR. SPECIFIC OBJECTIVES 1. To determine if normalization of CRT is

Fluid Responsiveness in HFNC Patients

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STUDY BACKGROUND The plethysmographic variation index (PVi) is a measure of the respiratory-induced variations in the plethysmographic waveform. Interestingly, in mechanically ventilated patients and under certain conditions, PVi may reflect fluid responsiveness (FR) (Loupec T Crit Care Med 2011;

Effect of Dexmedetomidine on Postoperative Delirium Inflammasome Activation Inhibition

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Delirium is an acute and subacute comorbid syndrome characterized by decreased awareness and cognitive dysfunction accompanied by attention deficit. It varies from 20% to 80% in patients entering the ICU. If delirium occurs in the intensive care unit, complications such as unintended intubation,

Noninvasive Measurements of Renal Perfusion During Cardiac Surgery

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Acute kidney injury (AKI) is an unfortunately common complication of cardiac surgery that occurs in up to 40% of patients and results in increased mortality, prolonged ICU and hospital length of stay. AKI after cardiac surgery is not a benign complication, increasing mortality from 1% to 19% in

Sigh in Acute Hypoxemic Respiratory Failure

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Steering committee: Tommaso Mauri, Laurent Brochard, Jean-Michel Constantin, Giuseppe Foti, Claude Guerin, Jordi Mancebo, Paolo Pelosi, Marco Ranieri, Antonio Pesenti Statistical support: Carla Fornari and Sara Conti Specific aims This pilot RCT will serve to test the hypothesis that application of

Mechanisms for Individual Differences in Hypertension in Obstructive Sleep

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We seek to assess the clinical determinants and molecular/genetic mechanisms underlying known individual differences in BP response to obstructive sleep apnea (OSA). This will result in a more personalized approach to BP management of OSA patients. Hypertension is a common consequence of OSA. Animal

Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study

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Early Goal Directed Therapy using a Physiological Holistic View. A multicenter study in Latin America: The ANDROMEDA-SHOCK Study Hypothesis Peripheral perfusion guided resuscitation in septic shock is associated with lower mortality, less organ dysfunctions, less mechanical ventilation (MV), less

Ephedrine and Phenylephrine for Spinal Hypotension

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Study design: A prospective randomized clinical double-blind study using a computer generated randomization will be conducted in a Women's Health Hospital, Assuit University. Neither the doctor "investigator" nor the participant "parturient" will be aware of the group allocation or the drug used.

Oral Propranolol Improve Retinopathy of Prematurity Outcomes in Very Preterm Infants

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Retinopathy of prematurity (ROP) is a major cause of blindness and visual impairment in children in both developing and developed countries around the world. ROP is a multifactorial disease characterized by perturbation of normal vascular development in the retina. The pathogenesis of ROP is

Obstructive Sleep Apnea and Arousal Threshold in Patients With Post-traumatic Stress Disorder

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Obstructive sleep apnea (OSA) is a clinically relevant disease that is associated with cardiovascular, metabolic, and neurocognitive consequences. OSA is a very common disease; the Wisconsin Sleep Cohort Study found that OSA affects 2% of women and 4% of men aged 30-60. However, these data predate

Remote Ischemic Preconditioning of Human Myocardium

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The investigators will study: 1. Resistance of isolated right atrial pectinate muscle trabeculae to simulated hypoxia/reperfusion in functional organ bath model 2. Resistance of isolated right atrial pectinate muscle trabeculae to induction of apoptosis by simulated hypoxia/reperfusion 3. Resistance

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