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A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter.

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The human norepinephrine transporter (NET) is implicated in many neurological disorders and is a target of tricyclic antidepressants and nisoxetine (NX). We used molecular docking simulations to guide the identification of residues likely to affect substrate transport and ligand interactions at NET.

The effect of chronic clonidine administration on salivary glands and caries in the rat.

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Clonidine is a widely prescribed, centrally acting antihypertensive with proposed pharmacologic mechanisms of stimulation of central postsynaptic alpha(2)-adrenergic receptors and agonist activity at presynaptic alpha(2)-adrenergic receptors, interfering with peripheral regulation of norepinephrine

A norepinephrine coated magnetic molecularly imprinted polymer for simultaneous multiple chiral recognition.

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A newly designed molecularly imprinted polymer (MIP) material was developed and successfully used as recognition element for enantioselective recognition by microchip electrophoresis. In this work, molecularly imprinted polymers were facilely prepared employing Fe3O4 nanoparticles (NPs) as the

Fetal sheep temperatures in utero during cooling and application of triiodothyronine, norepinephrine, propranolol and suxamethonium.

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Fetal sheep (n = 13) were chronically instrumented to measure temperatures in the maternal femoral artery (MAT), the amniotic fluid (AFT), the fetal brown adipose tissue (BFT) and the fetal arterial blood (DAT). Cooling loops were inserted into the amniotic cavity. In 4 fetuses osmotic minipumps

Effects of a selective iNOS inhibitor versus norepinephrine in the treatment of septic shock.

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Inhibition of NOS is not beneficial in septic shock; selective inhibition of the inducible form (iNOS) may represent a better option. We compared the effects of the selective iNOS inhibitor BYK191023 with those of norepinephrine (NE) in a sheep model of septic shock. Twenty-four anesthetized,

Effect of cooling on electrical field stimulation and norepinephrine-induced contraction in isolated hypertrophic human nasal mucosa.

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BACKGROUND Exposure to cold causes cutaneous vasoconstriction to reduce body heat loss, while the nasal cavity warms up the inspired cold air. This suggests cooling might evoke a different response in nasal mucosa blood vessels than in cutaneous blood vessels. Thus, the aim of this study was to

Effects of catecholamines on blood pressure in the long bone marrow cavity in rats with bisphosphonate-induced osteopetrosis.

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Osteopetrosis is a congenital metabolic bone disease characterized by skeletal sclerosis resulting from defective osteoclast-mediated bone resorption. The disease may, inter alia, be caused by the administration of bisphosphonates (e.g. pamidronate) particularly in young humans. The issue of the

Effects of catecholamines on blood pressure in the femoral bone marrow cavity in ovariectomized rats.

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Menopausal women display changes in the osseous tissue (osteoporosis, pathologic fractures) and disorders in the function of cardiovascular system (hypertension, cardiovascular disease, arteriosclerosis, calcification). Additionally, interdependence was observed between the loss of osseous tissue

Role of endogenous norepinephrine in microcirculation after experimental acute spinal cord injury.

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The effects of endogenous norepinephrine on changes in spinal microcirculation after acute injury of the spinal cord were examined in rabbits. 6-hydroxydopamine (6-OHDA), which selectively destroys catecholamine neurons, was injected into the subarachnoid cavity of the rabbit spinal cord.

Changes in cardiovascular function based on adrenalin and norepinephrine metabolism in ovariectomized rats.

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Menopause is a cardiovascular risk factor in women, and cardiovascular changes during perimenopause can increase the risk. We observed the influence of plasma adrenalin and norepinephrine and their metabolites on the cardiovascular system and the rectification effect of estrogen in ovariectomized

Time of peritoneal cavity exposure influences postoperative glucose production.

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OBJECTIVE To examine the effect of the duration of peritoneal cavity exposure on glucose metabolism after abdominal surgery. METHODS In eight otherwise healthy patients (ASA 1) with uterine myoma, endogenous glucose production (Ra glucose) was measured immediately before and two hours after

Effect of pamidronate on the action of catecholamines on blood pressure in the marrow cavity of long bones in rats with prednisolone-induced osteoporosis.

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Pamidronate is a representative of bisphosphonates, which are effectively used in the treatment of bone diseases. Although a number of properties of pamidronate have been recognized which influence the metabolic process in bones, the issue of the effect of bisphosphonates on the function of blood

Excimer emission in norepinephrine and epinephrine drugs with α- and β-cyclodextrins: spectral and molecular modeling studies.

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The inclusion complexation behavior of norepinephrine (NORE) and epinephrine (EPIN) with native cyclodextrins (α-CD and β-CD) were investigated by UV-visible, fluorimetry, time-resolved fluorescence, SEM, TEM, FT-IR, (1)H NMR, DSC, powder XRD and PM3 methods. Single emission was observed in aqueous

Caries increment in children and urinary catecholamines: findings at one-year.

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This one-year follow-up study investigates the relationship between urinary catecholamine levels and dental caries increment in 314 children, boys and girls, ages six to eight years. Dental caries was recorded clinically and radiographically and oral hygiene was evaluated by recording the dental

Urinary catecholamine levels in children with and without dental caries.

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Urinary catecholamines have been used to measure emotionally stressful states which may affect the development of dental caries. This study investigates the hypothesis that children with and without dental caries do not differ significantly in the mean values of urinary catecholamines such as

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