Patients will receive daily oral low dose Acetylsalicylic acid (75 mg) starting day 20 of the previous cycle withGonadotrophin releasing hormone agonist (GnRH agonist)

Patients will receive daily oral low dose Acetylsalicylic acid (75 mg) and Low dose prednisolone (10 mg/day) starting day 20 of the previous cycle withGonadotrophin releasing hormone agonist (GnRH agonist).

Infertility

daily oral low dose prednisolone (10 mg/day) :a glucocorticoid

prednisolone

daily oral low dose Acetylsalicylic acid (75 mg) : Antiplatelet agent

Acetyl Salicylic acid

KasralainiH

The Value of Prednisolone With Aspirin Before Embryo Transfer in Intracytoplasmic Sperm Injection (ICSI) Cycles

The Value of Addition of Prednisolone to Acetylsalicylic Acid Prior to Embryo Transfer in Patients With First ICSI Cycles: A Randomized Controlled Trial

Detection of gestational sac , embryo pole and fetal pulsations by transvaginal ultrasound

number of oocytes retrieved during ovum pickup per cycle.

The number of oocytes fertilized by intracytoplasmic sperm injection per cycle.

number of embryos of any grade ( first, second, third or fourth grade) per cycle

embryo quality by grade ( first, second, third or fourth) per cycle.

Detection of 2 gestational sacs with positive fetal poles and pulsations per cycle.

Amira S Dieb

Ob/Gyn Lecturer

Kasr El Aini Hospital

Poly Cystic Ovary Syndrome

Fenugreek seeds extract 500 mg

Clinical Evaluation of Furocyst in Patients With Poly Cystic Ovary Syndrome

Efficacy and Safety of Furocyst in Patients With Poly Cystic Ovary Syndrome

Chemical Resources

Women who met the 2003 Rotterdam criteria, which require a minimum of two of the following three criteria:
Oligo- or anovulation
Clinical and/or biochemical signs of hyperandrogenism
Polycystic ovaries and exclusion of other etiologies (congenital adrenal hyperplasia, androgen-secreting tumors, Cushing's syndrome)

Control

PCOS

Total

Sex: Female, Male

Region of Enrollment

Using serum total testosterone to represent the severity of hyperandrogenism.

Total Testosterone

BMI categorization was based on the WHO Asia-Pacific classification for obesity, which was defined as BMI ≧ 25 kg/m2(WHO: Obesity: preventing and managing the global epidemic. Geneva: WHO; 2000).

A fasting serum insulin level of greater than the upper limit of normal for the assay used (approximately 60 pmol/L) is considered evidence of insulin resistance.

Fasting Insulin

Fasting blood sugar (FBS) measures blood glucose after you have not eaten for at least 8 hours. It is often the first test done to check for prediabetes and diabetes.
World Health Organization 2006 diagnostic criteria for diabetes were employed (fasting plasma glucose ≥7.0 mmol/L or two hour plasma glucose ≥11.1 mmol/L).

Fasting Glucose

2-hour postprandial blood sugar measures blood glucose exactly 2 hours after you start eating a meal. This is not a test used to diagnose diabetes.
World Health Organization 2006 diagnostic criteria for diabetes were employed (fasting plasma glucose ≥7.0 mmol/L or two hour plasma glucose ≥11.1 mmol/L).

Two Hour Glucose

HOMA-IR = [fasting insulin (in μIU/mL) × fasting glucose (in mg/dL)]/405.

Homeostasis Model Assessment Insulin Resistance Index (HOMA-IR)

Hypercholesterolemia was defined as >6 mmol / L.

Cholesterol

Abnormal serum triglycerides defined as ≥ 1.7 mmol/L

Triglycerides

Metabolic syndrome was defined (2005 National Cholesterol Education Program, Adult Treatment Panel III) as the presence of at least three of the following criteria:
abdominal obesity (waist circumference >80 cm in women); serumtriglycerides≥1.7 mmol/L; serumHDL<1.3 mmol/L; systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥85 mmHg; and fasting plasma glucose ≥7.0 mmol/L.

Lipid profiles, including total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and sex hormone binding globulin (SHBG).
Abnormal LDL was ≧4.14mmol/L.

Impaired glucose tolerance was defined as two hour glucose levels of 7.8-11.1 mmol/L in the 75 g oral glucose tolerance test. In women with impaired glucose tolerance, the fasting plasma glucose level should be <7 mmol/L.

BMI categorization was based on the WHO Asia-Pacific classification for obesity, which was defined as BMI ≧ 25 kg/m2(WHO: Obesity: preventing and managing the global epidemic. Geneva: WHO; 2000).
Women who met the 2003 Rotterdam criteria, which require a minimum of two of the following three criteria:
Oligo- or anovulation
Clinical and/or biochemical signs of hyperandrogenism
Polycystic ovaries and exclusion of other etiologies (congenital adrenal hyperplasia, androgen-secreting tumors, Cushing's syndrome)

Obese With PCOS

Obese With Control

BMI categorization was based on the WHO Asia-Pacific classification for obesity, which was defined as BMI < 25 kg/m2(WHO: Obesity: preventing and managing the global epidemic. Geneva: WHO; 2000).
Women who met the 2003 Rotterdam criteria, which require a minimum of two of the following three criteria:
Oligo- or anovulation
Clinical and/or biochemical signs of hyperandrogenism
Polycystic ovaries and exclusion of other etiologies (congenital adrenal hyperplasia, androgen-secreting tumors, Cushing's syndrome)

Non-obese With PCOS

BMI categorization was based on the WHO Asia-Pacific classification for obesity, which was defined as BMI < 25 kg/m2(WHO: Obesity: preventing and managing the global epidemic. Geneva: WHO; 2000).

ovarian cysts/fetma

The Value of Prednisolone With Aspirin Before Embryo Transfer in Intracytoplasmic Sperm Injection (ICSI) Cycles

Clinical Evaluation of Furocyst in Patients With Poly Cystic Ovary Syndrome

To Study Polycystic Ovary Syndrome in Taiwanese Women

Environmental Factors in the Development of Polycystic Ovary Syndrome

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