Patients undergoing liver transplantation without regional cerebral oxygenation monitoring using a cerebral oximeter.

Patients undergoing liver transplantation with regional cerebral oxygenation monitoring using a cerebral oximeter.

Liver Failure

Cerebral oximeter

Queen Mary Hospital

Queen mary Hospital

A Prospective Randomized Controlled Trial on the Use of Cerebral Oximetry in Adult Chinese Patients Undergoing Liver Transplantation

Use of Cerebral Oximetry In Adult Chinese Patients For Liver Transplantation

To assess patients experience of development of delirium

To assess the time patients required to return health conditions within 10 days after surgery

To monitor any other complications developed by patients after liver transplant

Dr. Kenneth Siu-Ho Chok

Associate Professor

The University of Hong Kong

Individuals were exposed to intermittent hypoxia and locomotor training to establish our interventions (set up lab, train personnel, develop study protocols/interventions, etc)

Individuals were exposed to 10 days of intermittent hypoxia to determine the effect of this intervention on ventilatory long-term facilitation, as measured by minute ventilation

Individuals were exposed to 10 days of intermittent hypoxia to determine changes in ventilatory loading.

This group of participants were exposed to intermittent hypoxia and/or locomotor training. They were enrolled only to establish and streamline the protocol and train the laboratory personnel.

Phase 1 Arm (Pilot)

This group of subjects were exposed to intermittent hypoxia and minute ventilation was recorded to determine whether ventilatory long term facilitation (LTF) was present.

Phase 2 Arm (Long Term Facilitation)

This group of subjects was exposed to intermittent hypoxia and ventilatory loading was assessed.

Phase 3 Arm (Ventilatory Loading)

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Region of Enrollment

Minute ventilation (Ve) is the volume of gas inhaled or exhaled from a person's lungs per minute. Minute ventilation during the end-recovery (ER) period at initial (i.e., Days 1 and 2, initial ER period) and final (i.e., Days 9 and 10, final ER period) days of the IH protocol were normalized to values from baseline with elevated carbon dioxide (B2) within each individual session to characterize daily effects of exposure to IH at the beginning and end of treatment. Values from baseline with elevated carbon dioxide and the ER period during the final days of the protocol (final B2 and final ER period, respectively) also were normalized to elevated carbon dioxide baseline during initial days of the protocol (initial B2) to describe the cumulative effects of repeated exposure to IH. Outcomes are reported as % increases in minute ventilation during initial and final treatment sessions for daily/acute effects and cumulative/chronic effects.

Individuals were exposed to intermittent hypoxia and locomotor training to establish our interventions (set up lab, train personnel, develop study protocols/interventions, etc)
Intermittent Hypoxia: Individuals received exposure to intermittent hypoxia for 10 days, and placebo for 1-2 days.
Locomotor Training: Individuals received 10 days of locomotor training, intense walking training on a treadmill with body weight support. Manual assistance was provided at the legs to optimize stepping patterns.

Individuals were exposed to 10 days of intermittent hypoxia to determine the effect of this intervention on ventilatory long-term facilitation, as measured by minute ventilation.
Intermittent Hypoxia: Individuals received exposure to intermittent hypoxia for 10 days, and placebo for 1-2 days.

Phase 2 Arm (LTF)

Individuals were exposed to 10 days of intermittent hypoxia to determine changes in ventilatory loading.
Intermittent Hypoxia: Individuals received exposure to intermittent hypoxia for 10 days, and placebo for 1-2 days.

Minute Ventilation - Phase 2

Ventilatory load compensation was assessed in two ways. Mean slopes for (1) pressure vs. resistance (P vs R) and (2) airflow vs. resistance (AF vs R) were calculated for pre- and post-IH treatment.

Ventilatory Loading - Phase 3

Overall Study

Dr. Nicole Tester

Spinal Cord Injuries

Brown Sequard

Central Cord Syndrome

Individuals received exposure to intermittent hypoxia for 10 days, and placebo for 1-2 days.

Intermittent Hypoxia

Individuals received 10 days of locomotor training, intense walking training on a treadmill with body weight support. Manual assistance was provided at the legs to optimize stepping patterns.

Locomotor Training

North Florida/South Georgia Veterans Health System

Effects of Breathing and Walking Treatments on Recovery Post-Spinal Cord Injury

Intermittent Hypoxia and Locomotor Training: Effects Following SCI

VA Office of Research and Development

University of Florida

Wayne State University

Esophagectomy via Right Side Thoracotomy Plus Midline Laparotomy Approach

Esophageal Cancer

Postoperative Complications

Diaphragm

Pulmonary Function

Ivor-Lewis Esophagectomy

Esophagectomy through Left Side Thoracotomy

Sweet Esophagectomy

Thoracic Surgery Department, West China Hospital of Sichuan University

Esophagectomy Associated Respiratory Complications: Ivor-Lewis Versus Sweet Approaches

A Phase Ⅲ Study of Respiratory Complications Associated With Esophagectomy Through Either Ivor-Lewis or Sweet Approach for the Treatment of Middle or Lower Third Intrathoracic Esophageal Carcinoma

West China Hospital / Longqi Chen, Professor

Sichuan University

Traumatic Brain Injury

IV Progesterone

Emory University School of Medicine - Dept. of Emergency Medicine

Progesterone Treatment of Blunt Traumatic Brain Injury

ProTECT: Single Center, Phase II (Pilot), Double Blind, 4:1 Randomized, Placebo Controlled Clinical Trial for Progesterone Treatment of Moderate and Severe Blunt TBI

paresis/hypoxia

A Prospective Randomized Controlled Trial on the Use of Cerebral Oximetry in Adult Chinese Patients Undergoing Liver Transplantation

Effects of Breathing and Walking Treatments on Recovery Post-Spinal Cord Injury

Esophagectomy Associated Respiratory Complications: Ivor-Lewis Versus Sweet Approaches

Progesterone Treatment of Blunt Traumatic Brain Injury

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