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Chitosan-phospholipid blend for sustained and localized delivery of docetaxel to the peritoneal cavity.

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Localized and sustained delivery of chemotherapeutics presents a "magic bullet" effect by providing high drug concentrations at the target site, extended drug exposure and reduced systemic toxicity. In the present study, an injectable chitosan-phospholipid (PoLi(gel)) blend is put forth as a

Role of topical phospholipids in the prophylaxis of silicone elastomer-associated infection in the abdominal cavity.

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The present study evaluated the influence of phospholipids (phosphatidyl choline and phosphatidyl inositol) on the prevention of abdominal biomaterial-associated infection. Phospholipid-impregnated silicone elastomer (SE) fragments were either intraperitoneally implanted in rats or immersed in serum

Local polarity and hydrogen bonding inside the Sec14p phospholipid-binding cavity: high-field multi-frequency electron paramagnetic resonance studies.

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Sec14p promotes the energy-independent transfer of either phosphatidylinositol (PtdIns) or phosphatidylcholine (PtdCho) between lipid bilayers in vitro and represents the major PtdIns/PtdCho transfer protein in the budding yeast Saccharomyces cerevisiae. Herein, we employ multi-frequency high-field

Cavity Orientation Regulated by Mixture Composition and Clustering of Amphiphilic Cyclodextrins in Phospholipid Monolayers.

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Artificial supramolecular-hierarchical structures that emulate nature represent an overcoming alternative for the design of new drug delivery systems. Thermodynamic and topographic properties of films formed by a monoacylated amphiphilic β-cyclodextrin (βCD-C16) with the phospholipid

Thymus essential oil extraction, characterization and incorporation in phospholipid vesicles for the antioxidant/antibacterial treatment of oral cavity diseases.

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The aim of the work was to extract, characterize, and formulate Thymus capitatus (Tymbra capitata) essential oil in phospholipid vesicles: liposomes, glycerosomes and Penetration Enhancer-containing Vesicles (PEVs). The steam-distilled essential oil was mainly composed of carvacrol. The oil was

Phospholipid flipping involves a central cavity in P4 ATPases.

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P4 ATPase flippases translocate phospholipids across biomembranes, thus contributing to the establishment of transmembrane lipid asymmetry, a feature important for multiple cellular processes. The mechanism by which such phospholipid flipping occurs remains elusive as P4 ATPases transport a giant

Crystal structure of mouse MD-1 with endogenous phospholipid bound in its cavity.

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MD-1 is a glycoprotein that associates with a B-cell-specific RP105 protein and has a low sequence identity of 16% to MD-2 that associates with Toll-like receptor 4 and recognizes endotoxic lipopolysaccharide. MD-1 and RP105 are supposed to mediate lipopolysaccharide recognition; however, little is

Shear induced carboplatin binding within the cavity of a phospholipid mimic for increased anticancer efficacy.

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Vesicles 107 ± 19 nm in diameter, based on the self-assembly of tetra-para-phosphonomethyl calix[4]- arene bearing n-hexyl moieties attached to the phenolic oxygen centres, are effective in binding carboplatin within the cavity of the macrocycle under shear induced within a dynamic thin film in a

Lipids in human parotid saliva with regard to caries experience.

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It has been reported that saliva may play an important role in the prevention and development of enamel caries and that both lipids and protein contents in saliva may be relevant to this role. This study examined the lipid and protein levels in saliva from individuals differing in caries experience.

[Tubular structures revealed using tannic acid on the surface of the epithelium of the tympanic cavity of the chicken].

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We have studied the ultrastructure of the epithelium lining the tympanic cavity of chicken, using two embedding techniques. In certain cases, the epithelium was minced in Karnovsky fixative, post-fixed in osmium, dehydrated and embedded in Epon, following the usual methods. No morphologically

Direct determination of hydration in the interdigitated and ripple phases of dihexadecylphosphatidylcholine: hydration of a hydrophobic cavity at the membrane/water interface.

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Hydrophobic cavities at the membrane/water interface are stably expressed in interdigitated membranes. The nonsolvent water associated with 1,2-di-O-hexadecyl-sn-glycero-3-phosphocholine (Hxdc(2)GroPCho) in the interdigitated (L(beta)I) and ripple (P(beta')) states and with its ester analogue 1,

Sustained delivery of cytarabine-loaded vesicular phospholipid gels for treatment of xenografted glioma.

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This study described the development of vesicular phospholipid gels (VPGs) for sustained delivery of cytarabine (Ara-C) for the treatment of xenografted glioma. Ara-C-loaded VPGs in the state of a semisolid phospholipid dispersion looked like numerous vesicles tightly packing together under the

Interaction of the Tim44 C-terminal domain with negatively charged phospholipids.

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The translocation of proteins from the cytosol into the mitochondrial matrix is mediated by the coordinated action of the TOM complex in the outer membrane, as well as the TIM23 complex and its associated protein import motor in the inner membrane. The focus of this work is the peripheral inner

Mechanism of alpha-cyclodextrin induced hemolysis. 2. A study of the factors controlling the association with serine-, ethanolamine-, and choline-phospholipids.

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A nuclear magnetic resonance (NMR) spectroscopy and molecular modeling study of the interaction between alpha-cyclodextrin (alpha-CD) and phospholipids with serine, ethanolamine, or choline headgroups is presented. The experimental approach is based on 31P and 1H NMR measurements on small

The central plug in the reconstituted undecameric c cylinder of a bacterial ATP synthase consists of phospholipids.

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The isolated rotor cylinder of the ATP synthase from Ilyobacter tartaricus was reconstituted into two-dimensional crystalline arrays. Atomic force microscopy imaging indicated a central cavity on one side of the rotor and a central plug protruding from the other side. Upon incubation with

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