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physostigmine/dichloromethane
Länken sparas på Urklipp
5 resultat
A concise synthesis of physostigmine from skatole and activated aziridine via alkylative cyclization.
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A concise synthetic route to physostigmine has been developed, where the key step relies on the alkylative cyclization of 1,3-dimethylindole with (Z)-aziridine catalyzed by Sc(OTf)3 and TMSCI in dichloromethane at -30 degrees C, to give 8 in 90% yield, which, in turn, can be readily converted into
Acetylcholinesterase Inhibitor from Anthocleista vogelii Leaf Extracts.
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BACKGROUND
Anthocleista vogelii (Planch) is used in folk medicine in conditions related to inflammation and oxidative stress.
OBJECTIVE
The leaf extracts were investigated for their bioactive constituents in our quest for novel compounds for the management of neurodegenerative
Acetylcholinesterase inhibitory activity of uleine from Himatanthus lancifolius.
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Application of acetylcholinesterase (AChE) inhibitors is the primary treatment for Alzheimer's disease. Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. The aim of this work was to evaluate Himatanthus lancifolius (Muell. Arg.) Woodson, a
Cholinesterase enzymes inhibitors from the leaves of Rauvolfia reflexa and their molecular docking study.
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Plants of the Apocynaceae family have been traditionally used in the treatment of age-related brain disorders. Rauvolfia reflexa, a member of the family, has been used as an antidote for poisons and to treat malaria. The dichloromethane, ethanol and methanol extracts from the leaves of Rauvolfia
Combination of bioautography with HPTLC-MS/NMR: a fast identification of acetylcholinesterase inhibitors from galbanum(†).
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BACKGROUND
In the search for new natural compounds with acetylcholinesterase (AChE) inhibitory activity this study focused on galbanum, the oleo gum-resin from Ferula gummosa Boiss., which had shown AChE inhibitory activity in a screening.
OBJECTIVE
The isolation of bioactive compounds from plant
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