Process for isolation of 1-(3,4-methylenedioxy-phenyl)-1E-tetradecene from Piper longum. Processes for synthesis of 1-(3,4-methylenedioxy-phenyl)-1E-tetradecene; its stereoisomers and analogues are disclosed. The compounds isolated and synthesized according to this invention have immunomodulatory properties and can be used to treat tumors and infections.

National Institute of Immunology

Process for isolation and synthesis of 1-(3,4 methylenedioxy-phenyl)-1E-tetradecene and its analogues and their activities against tumors and infections

The present invention is directed to the use of extracts or of extract compounds from Piper cubeba L. as active components in a medicament for the treatment of cancer. The invention also relates to a method for the preparation of a dry extract from the fruit of Piper cubeba L.

Kreuter; Matthias-Heinrich

Yam; Jian Ying

Berger-Buter; Karin

Viridis Pharmaceutical Limited

Use of extracts or materials extracted from Piper cubeba L. as an effective component in a drug for the treatment of cancer diseases

The present invention relates to a method for providing .alpha.-glucosidase inhibition to a subject by administering a pharmaceutical composition comprising a .alpha.-glucosidase inhibitory agent selected from pipataline (formula 1a), sesamin (formula 1b), pellitorine (Formula 1c), guineensine (Formula 1d) and brachystamide-B (formula 1e) having therapeutic application for diabetes mellitus, cancer, viral diseases such as hepatitis B and C, HIV, AIDS etc; also the invention provides a process for the isolation of said .alpha.-glucosidase inhibitory agent from the plant source Piper longum in significant yields.

piper/neoplasms

Process for isolation and synthesis of 1-(3,4 methylenedioxy-phenyl)-1E-tetradecene and its analogues and their activities against tumors and infections

Use of extracts or materials extracted from Piper cubeba L. as an effective component in a drug for the treatment of cancer diseases

.alpha.-Glucosidase inhibitors from a natural source

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