24 Patient will receive Curcumin (CC) pills, within 24 hours post-operatively (as long as they are able to take oral medication). It will then be continued TID

24 Patient will receive Placebo pills, within 24 hours post-operatively (as long as they are able to take oral medication. It will then be continued TID.

Hematoma, Subdural, Chronic

Curcumin (turmeric extract), over the counter supplement (1 capsule/three times a day). According to the Company, each capsule contains: 270 mg of pure curcuminoids (curcumin) and 3 mg of black pepper extract. Recommended serving size is 3 capsules per day in total, the patients will receive 810 mg of pure curcumin and 9 mg of black pepper extract (peperine/BioPerine) per day.

Curcumin Pill

The placebo pill is a vegetarian cellulose capsule, with cellulose powder inside. The composition is cellulose and magnesium stearate.

Placebo pills

University of New Mexico Health Sciences center

Curcumin/Turmeric as a Treatment for Patients With Subdural Hematomas Recurrence

Clinical Action of Curcumin/Turmeric in Chronic Subdural Hematoma Recurrence

Change of the total hematoma cavity volume compared to post-subdural drain removal to volumes of less than 80 cc in post-surgical patients

Change rate of persistent or recurrent neurological symptoms

University of New Mexico

This is an experimental study, each consented subject will be instructed that he/she will be randomized to either the placebo group or the curcumin group.

This is a double-blinded, randomized placebo-controlled pilot study. The patients, neurosurgeons, nurses and clinical coordinators will be blinded except for the research pharmacists who will keep a key linking a code # on a bottle handed to the clinical coordinator and the patient's medical record number (MRN #). The pill bottles handed to the clinical coordinator will be identical for placebo and CC.

Curcumin 1.2 g / black pepper 10 mg a day for 3 months, plus recommendations to decrease calories intake and do exercise.

Hydrolyzed collagen 1.2 g / black pepper 10 mg a day for 3 months, plus recommendations to decrease calories intake and do exercise.

Metabolic Syndrome

Curcumin

Hydrolyzed collagen

Biomedical Research Unit. IMSS. Durango

Oral Curcumin Administration to Remit Metabolic Syndrome

Efficacy of Oral Curcumin Administration on Metabolic Syndrome Remission.

Presence of two or less metabolic syndrome criteria, according to the ATP III criteria.

Fernando Guerrero Romero MD

Head of the research unit

Coordinación de Investigación en Salud, Mexico

Study groups:
Intervention group: curcumin 1.2 g / black pepper 10 mg a day for 3 months, plus recommendations to decrease calories intake and do exercise.
Control group: hydrolyzed collagen 1.2 g / black pepper 10 mg a day for 3 months, plus recommendations to decrease calories intake and do exercise.

Neither the patient nor the treating doctor will know the study group the participant was randomized.

Consumption of a high fat meal (1000kcal, 45g fat)

Consumption of a high fat meal (1000kcal, 45g fat) with 2g of spice (mix of black pepper, basil, bay leaf, cinnamon, coriander, cumin, ginger, oregano, parsley, rosemary, red pepper, turmeric and thyme) incorporated into the meal.

Consumption of a high fat meal (1000kcal, 45g fat) with 6g of spice (mix of black pepper, basil, bay leaf, cinnamon, coriander, cumin, ginger, oregano, parsley, rosemary, red pepper, turmeric and thyme) incorporated into the meal.

piper/triglyceride

Curcumin/Turmeric as a Treatment for Patients With Subdural Hematomas Recurrence

Oral Curcumin Administration to Remit Metabolic Syndrome

The Acute Effect of Spices on Vascular Health

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