poliomyelitis/albumin

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Biochemical alterations in acute human poliomyelitis electrolyte patterns and trends.

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Pronounced alterations occur in the biochemical findings in acute poliomyelitis. These are derived from three major mechanisms: (a) inefficient pulmonary gaseous exchange, resulting in respiratory acidosis; (b) profound changes in nitrogen metabolism, resulting in decreased serum albumin, tissue

Inactivation of viruses during ultraviolet light treatment of human intravenous immunoglobulin and albumin.

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A comparison of ultraviolet (UV) irradiation of two wavelength ranges UVB (280-320 nm) and UVC (lower than 280 nm) showed that UVC in particular could very effectively inactivate, in intravenous immunoglobulin (IVIG) and albumin preparations, non-enveloped and non-acid labile model viruses (i.e.,

[Validation of the virus inactivation capacity of a procedure of human plasma albumin purification by chromatography].

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Almost the whole of the human plasma albumin preparations intended for clinical or biological uses is at present fractionated by cold ethanol precipitation technics based on the Cohn method. However, ion-exchange chromatographic processes have been recently developed. The aim of this work was the

Alterations in serum protein levels in acute human poliomyelitis: Rationale for therapy.

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Serial determinations of serum protein levels in acute human poliomyelitis revealed a progressive drop of the serum albumin level which bore close relationship to the amount of clinical paralysis. This loss of serum albumin began about the third day after onset of clinical symptoms and progressed to

Infectivity of ribonucleic acid from poliovirus in human cell monolayers.

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Ribonucleic acid prepared by the method of Gierer and Schramm from concentrated and partially purified types I and II polioviruses has been demonstrated to be infectious for HeLa and human amnion cells in monolayers. In areas of cytopathogenic action resulting from invasion of cells by RNA, intact

Whole-body protein turnover and hepatic protein synthesis are increased by vaccination in man.

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1. The ability of diphtheria-tetanus-poliomyelitis-typhoid vaccination to induce modifications in protein metabolism was investigated in post-absorptive healthy humans. 2. Seven subjects were studied before and 2 days after vaccination. They underwent an intravenous primed constant infusion of

A history of immune globulin therapy, from the Harvard crash program to monoclonal antibodies.

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Processes for the large-scale fractionation of human plasma using cold ethanol were initially developed by Edwin Cohn and his colleagues at Harvard to provide albumin as a treatment for shock in World War II. Procedures for further purification of gamma globulins and other proteins precipitating at

Risk factors for physical disability in an aging cohort: the NHANES I Epidemiologic Followup Study.

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Successful improvement in health in our increasingly aged population will depend in substantial part on reduction of age specific disability levels. In turn, the epidemiologic model suggests that this requires identification of risk factors, development of intervention models, and testing of these

Efficient removal of viruses by a novel polyvinylidene fluoride membrane filter.

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Virus removal by a novel filter (Ultipor VF DV50), comprising three layers of PVDF membrane, has been evaluated by infectivity studies using a range of viruses and conditions. The filter was able to remove at least 6 log of various viruses, i.e. Sindbis and Semliki Forest (40-70 nm), herpes simplex

[Properties and virus safety of a pasteurized antithrombin III concentrate].

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In the last decade it appeared more than once that blood donations were contaminated by hitherto unknown viruses. Due to this fact, further steps have to be included into the manufacturing procedure of even up to now safe products from human plasma to eliminate potential new risks. A procedure is

The immune response to vaccination in undernourished and well-nourished Nigerian children.

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The immune response of young Nigerian children to a full course of infant immunizations was studied in relation to their nutritional state at the time of vaccination. No significant correlations were found between anthropometric measurements made at the time of vaccination and the antibody response

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