pre-eclampsia/seizures

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PP024. Effects of intravenous magnesium sulfate on the characteristics of eclamptic seizures induced by electrical stimuli in a rat preeclampsia/eclampsia model.

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OBJECTIVE Eclampsia is a serious complication of pregnancy and remains a leading cause of maternal mortality worldwide. Magnesium sulfate is commonly used in the prophylaxis and treatment of eclampsia. However, uncertainty remain regarding its anticonvulsant mechanism(s) of action. This study

The comparison of anti-seizure and tocolytic effects of phenytoin and magnesium sulphate in the treatment of eclampsia and preeclampsia: A randomised clinical trial.

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Background: To date, magnesium sulphate (MgSO4) is the treatment of choice for prevention of seizure in eclampsia and preeclampsia. However, there are some limitations in the administration of MgSO4 due to its tocolytic effects. The aim of this study was to compare the anticonvulsant and tocolytic

The effects of superoxide dismutase mimetic MnTMPyP on the altered blood-brain barrier integrity in experimental preeclampsia with or without seizures in rats.

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We investigated the effects of a cell-permeable superoxide dismutase mimetic, manganese(III) tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP) on blood-brain barrier (BBB) integrity following pentylenetetrazole (PTZ)-induced seizures in experimental preeclampsia symptoms induced by

Altered hippocampal arteriole structure and function in a rat model of preeclampsia: Potential role in impaired seizure-induced hyperemia.

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We investigated the effect of experimental preeclampsia on hyperemia during seizure in the hippocampus and vascular function and structure of hippocampal arterioles using Sprague Dawley rats (n = 14/group) that were nonpregnant, pregnant (d20), or had experimental preeclampsia (induced by a high

Role of magnesium sulfate in seizure prevention in patients with eclampsia and pre-eclampsia.

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Eclampsia is a leading cause of maternal mortality. The prevention of seizure activity in pre-eclampsia and recurrent seizures in eclamptic patients is an essential aspect of management. Many drugs with anticonvulsant properties have been used to treat patients with pre-eclampsia and eclampsia.

Anticonvulsant effects of magnesium sulfate on hippocampal seizures: therapeutic implications in preeclampsia-eclampsia.

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OBJECTIVE The objective of this study was to determine whether magnesium sulfate has central anticonvulsant effects. METHODS In three experiments we investigated the anticonvulsant properties of magnesium sulfate on the hippocampus because of its high density of N-methyl-D-aspartate receptors and

Transient diabetes insipidus in pregnancy complicated by hypertension and seizures.

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A case is presented of a primigravida with transient diabetes insipidus, gestational hypertension, and multiple seizures resistant to magnesium sulfate and diazepam. After addition of phenytoin, no further seizures occurred. Transient diabetes insipidus in pregnancy has been previously associated

Magnesium sulphate in the treatment of eclampsia and pre-eclampsia: an overview of the evidence from randomised trials.

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OBJECTIVE To evaluate the effectiveness of magnesium sulphate in the treatment of eclampsia and pre-eclampsia by a systematic quantitative overview of controlled clinical trials. METHODS Online searching of the MEDLINE database between 1966 and 1995, and scanning of the bibliography of known primary

Cortical blindness in postpartum preeclampsia progressing to eclampsia: case report.

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A 23-year-old woman who had an uneventful prenatal course and normal delivery developed severe, generalized headache and blurred vision on postpartum day four. The patient was noted to have generalized hyperreflexia and sustained ankle clonus. The blood pressure was 170/100 mm Hg, there was no

[Treatment of pre-eclampsia and eclampsia].

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From 1964 to 1984 (a 21-year period), out of 102.277 deliveries, there were 80 cases (0.8%) of eclampsia and 443 cases (4.3%) of pre-eclampsia. One patient (1.25%) with eclampsia died after delivery. Out of 539 children from mothers with pre-eclampsia and eclampsia, 44 (8.2%) died after birth. The

Progression of pre-eclampsia to eclampsia under spinal anaesthesia.

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Eclampsia remains a problem in the developing countries despite improvements in antenatal care and emergency obstetric facilities. It is an important cause of maternal morbidity and mortality in Nigeria. A 26-year-old primipara, residing in an urban city in Nigeria with antenatal care facilities,

Myasthenia gravis and preeclampsia: Dot all the I's and cross all the T's.

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Although rare, the co-occurrence of myasthenia gravis and preeclampsia during pregnancy is responsible for considerable maternal and foetal morbidity and mortality. Both careful selection of medications and a multidisciplinary approach are required for treating such cases. This study presents a case

Expectant management in severe preeclampsia: does magnesium sulfate prevent the development of eclampsia?

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Although magnesium sulfate has been traditional or standard treatment for severe preeclampsia and eclampsia to prevent convulsions, its efficiency has always been in doubt and its induced side-effects also make it controversial for use. In this study, 64 patients, diagnosed with severe preeclampsia,

Comparison of the Level of Magnesium during Maintenance between 2 Gram and 1 Gram per Hour Infusion in Overweight Mothers with Preeclampsia.

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Magnesium sulfate is most effective for prevention and treatment of convulsions among preeclampsia women. The therapeutic level of magnesium at 4.8 to 8.4 mg/dL and the overdose of magnesium may be fatal. In Maharat Nakhon Ratchasima Hospital, intravenous magnesium sulfate is used with the starting

Toxemia of pregnancy in sheep: a clinical, physiological, and pathological study.

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Toxemia was induced in 13 of 20 pregnant ewes by the stress of a change in environment and food deprivation late in pregnancy. Of the toxemic ewes, eight developed prominent neurological findings with convulsions, motor weakness, and blindness, whereas five ewes developed azotemia without

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