presbycusis/inflammation

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Inflammation is associated with a worsening of presbycusis: evidence from the MRC national study of hearing.

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OBJECTIVE Inflammaging, a state of chronic inflammation in the elderly, is now thought to be a key element of the ageing process and contributor to age-related disease. In a previously published study, we identified a significant association between inflammation levels and severity of presbycusis

Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy.

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Chronic, low-grade inflammation, or inflammaging, is a crucial contributor to various age-related pathologies and natural processes in aging tissue, including the nervous system. Over the past two decades, much effort has been done to understand the mechanisms of inflammaging in disease models such

Tinnitus, hearing loss and inflammatory processes in an older Portuguese population.

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Objective: Tinnitus is associated with various conditions such as presbycusis, infectious, autoimmune and many other diseases. Our study aims to identify an association between inflammatory markers and the presence of tinnitus or hearing loss (HL).Design: Exploratory study including a

Cholinergic Hypofunction in Presbycusis-Related Tinnitus With Cognitive Function Impairment: Emerging Hypotheses.

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Presbycusis (age-related hearing loss) is a potential risk factor for tinnitus and cognitive deterioration, which result in poor life quality. Presbycusis-related tinnitus with cognitive impairment is a common phenotype in the elderly population. In these individuals, the central auditory system

Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea.

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OBJECTIVE In our aging society, age-related hearing loss (ARHL) or presbycusis is increasingly important. Here, we study the mechanism of ARHL using the senescence-accelerated mouse prone 8 (SAMP8) which is a useful model to probe the effects of aging on biological processes. RESULTS We found that

Primary malleus fixation: diagnosis and treatment.

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Primary malleus fixation occurs in an otherwise normal middle ear without evidence of congenital deformity and without chronic inflammatory changes. It occurs in the latter decades of life and is frequently associated with sensorineural presbycusis. We believe it is a ligament ankylosis with

Histological considerations in implant patients.

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The selection of patients for cochlear implantation requires consideration of a variety of anatomical and histological facts. Mechanical impediments to cochlear implantation, including the consequences of chronic otitis media, bony obliteration of the membranous labyrinth, or labyrinthitis

Mean platelet volume and neutrophil to lymphocyte ratio in patients with tinnitus: a case-control study

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Introduction: Different theories have been proposed on the etiology of tinnitus, including metabolic and audiologic causes. We suggest that mean platelet volume and neutrophil to lymphocyte ratio levels change in tinnitus, indicating

Prevalence of ototoxic medication use among older adults in Beaver Dam, Wisconsin.

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OBJECTIVE Drug-related ototoxicity may exacerbate presbycusis (age-related hearing loss); yet, few data are available on the prevalence of ototoxic medication use by older adults. The purposes of this study were to assess the impact of aging and ototoxicity on hearing loss, the prevalence of

Current status of auditory aging and anti-aging research.

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The development of presbycusis, or age-related hearing loss, is determined by a combination of genetic and environmental factors. The auditory periphery exhibits a progressive bilateral, symmetrical reduction of auditory sensitivity to sound from high to low frequencies. The central auditory nervous

[Pathophysiology of auditory and speech perception].

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Auditory perception or hearing can be defined as the interpretation of sensory evidence, produced by the ears in response to sound, in terms of the events that caused the sound. We do not hear a window but we may hear a window closing. We do not hear a dog but we may hear a dog barking. And we do

Atorvastatin slows down the deterioration of inner ear function with age in mice.

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Statins have revolutionized the treatment of hypercholesterolemia due to their ability to inhibit cholesterol biosynthesis. Their immunomodulatory and anti-inflammatory effects and positive effects on the treatment of atherosclerosis and its complications are well known. Here, we describe the

Age-related hearing impairment-a risk factor and frailty marker for dementia and AD.

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Age-related hearing impairment (ARHI, also known as presbycusis) is potentially a reversible risk factor for dementia and Alzheimer disease (AD). Social isolation, loneliness, poor verbal communication, and cognitive reserve depletion might causally link ARHI with cognitive impairment. ARHI is an

Mechanisms of sensorineural cell damage, death and survival in the cochlea.

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The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well as the survival signaling pathways that can

The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss.

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Aging is associated with impairment of sensorial functions and with the onset of neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) bioavailability progressively decreases, we see a direct correlation with sensory impairment and cognitive performance in older

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