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primary immunodeficiency diseases/albumin
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Serum Bovine Immunoglobulin (SBI) in Children With Inflammatory Bowel Disease (IBD)
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The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study
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Over one million infants are born to HIV-1-infected women every year in Sub Saharan Africa. In Zimbabwe, annual births stand at 379,000 with approximately 48,000 infants being born every year to HIV-1-infected women on lifelong highly active antiretroviral therapy (HAART). Concerns have been
Empirical Antibiotics in Acute Inflammatory Gallbladder Disease
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1. Background In the case of acute cholecystitis, in which acute inflammation was manifested in patients with gallstones and was accompanied by pain and fever, cholecystectomy through surgery was the standard treatment, and the use of empirical antibiotics to treat inflammation and prevent
Pneumococcal Conjugate Vaccine in Aging Renal Transplant
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Objectives / Specific Aims
Normal aging is characterized by changes in the immune system that result in increased susceptibility to infections, poor response to new vaccine antigens, loss of protection offered by previous vaccinations and decreased immune surveillance. Despite the chronic
Diagnostic Biomarkers for Adult Hemophagocytic Lymphohistiocytosis in Critically Ill Patients (HEMICU)
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The investigators will draw blood samples of 100 patients at the time of diagnosis (each 50 with suspected or diagnosed HLH/sepsis) to determine a cytokine panel (c reactive protein (CRP), procalcitonin (PCT), interleukin (IL) 1β, IL-6, IL-8, IL-10, IL-18, IL-33, tumor necrosis factor (TNF) α,
A Pilot Study Using Autologous Regulatory T Cell Infusion Zortress (Everolimus) in Renal Transplant Recipients
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The purpose of this research study is to learn alternative ways to control the body's immune responses after renal transplantation. The investigator's goal is to prevent or reduce the side-effects of long-term immunosuppressive therapy.
By doing this study, the investigator hopes to learn how safe
Serum Level of Myokines and Protein Energy Wasting, Inflammation and Atherosclerosis in Hemodialysis Patients
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Study Design and Population
In this study, patients who underwent stable hemodialysis at least 3 months at Tung Taichung Metroharbor Hospital will be enrolled. Baseline clinical data such as age, sex, height, bodyweight , clinical etiology of Chronic kidney disease(CKD) if possible, comorbidities,
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies
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BACKGROUND
Pulmonary hypertension is a severe disorder defined by an elevated mean pulmonary arterial pressure (mPAP) as >25 mmHg at rest. A classification of the different types of pulmonary hypertension has been established according to shared pathologic and clinical features as well as similar
Faecal Microbiota Transplantation in Irritable Bowel Syndrome
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1. Background
Irritable bowel syndrome (IBS) is a chronic, debilitating, functional gastrointestinal disorder with estimated population prevalence in Europe between of 10 -15% (Ford et al). These symptoms can be debilitating and lead to a significant reduction in quality of life particularly in the
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery
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3 Background The use of cardiopulmonary bypass (CPB) during cardiac surgery elicits generalized non-specific systemic inflammatory response syndrome (SIRS) and subsequent activation of the cytokine, complement, and coagulation-fibrinolytic cascades (1). In approximately 11% of the patients SIRS may
Clinical and Mechanistic Demonstration of a Bioelectric Dressing System for Non-healing Wound Management: A Phase II Trial
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The PROCELLERA Antimicrobial Wound Dressing is considered a non-interactive wound dressing containing silver and zinc, classification product code MGP. Non-interactive wound dressings are considered by FDA to be non-significant risk, as per their Investigational Device Exemptions Manual (publication
Nutrition in Children With Food Allergy
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Prospective controlled study including patients with cow's milk allergy(6-36 months of age.During the first examination, the diagnosis will be assessed by pediatricians with great experience in food allergy, checking that the patient had undergone a standardized procedure. All cases with an unclear
Role of Polymorphisms in the Dectin-1 Gene in Determining the Risk of Candida Colonization and Infection in Critically Ill Patients
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Invasive fungal infections are associated with increased morbidity and mortality rates as high as 50% (1). Up to half occur in non-neutropenic; critically ill patients and the majority are due to Candida species. A number of randomised controlled trials (RCTs) have evaluated anti-fungal prophylaxis,
A Study Evaluating the Association of Inflammation With Hemodialysis Access Type
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A Study Of The Effect Of Hemodialysis Vascular Access Type On Markers Of Inflammation PI: Michele H. Mokrzycki MD, MS
Introduction/Background: The prevalence of chronic inflammation is high (35-65%) in end stage renal disease (ESRD) patients and is associated with an increased risk of
7-valent Pneumococcal Conjugated Vaccination
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Background:
Patients with human immunodeficiency virus (HIV) infection have higher incidence and recurrence rates of pneumonia and bacteremia caused by Streptococcus pneumoniae compared with the persons without HIV infection. Before the introduction of highly active antiretroviral therapy (HAART),
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