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Sida 1 från 41 resultat
Pyrazole carboxamides useful for the treatment of obesity and other disorders
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FIELD OF THE INVENTION
This invention relates to a series of pyrazole carboxamide derivatives, pharmaceutical compositions containing them and their preparation use in the treatment of central nervous system disorders and affective conditions. More particularly, the compounds of the invention are
Pyrazole carboxamides useful for the treatment of obesity and other disorders
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FIELD OF THE INVENTION
This invention relates to a series of pyrazole carboxamide derivatives, pharmaceutical compositions containing them and their preparation use in the treatment of central nervous system disorders and affective conditions. More particularly, the compounds of the invention are
Amino pyrazole derivatives useful for the treatment of obesity and other disorders
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FIELD OF THE INVENTION
This invention relates to a series of amino pyrazole derivatives, pharmaceutical compositions containing them and intermediates used in their preparation. The compounds of the invention are ligands for the neuropeptide Y subtype 5 (NPY5) receptor, a receptor which is
Pyrazoles for the treatment of obesity and other CNS disorders
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TECHNICAL FIELD
This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain pyrazole derivatives and their salts and
Pyrazoles for the treatment of obesity and other CNS disorders
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TECHNICAL FIELD
This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain pyrazole derivatives and their salts and
Pyrazole compounds and methods of making and using same
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BACKGROUND
Monoacylglycerol lipase (MAGL) is an enzyme responsible for hydrolyzing endocannabinoids such as 2-AG (2-arachidonoylglycerol), an arachidonate based lipid, in the nervous system. The serine hydrolase .alpha.-.beta.-hydrolase domain 6 (ABHD6) is another lipid mediator. Fatty acid amide
Pyrazole carboxamides as inhibitors of 11-.beta.-hydroxysteroid dehydrogenase-1
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FIELD OF THE INVENTION
The present invention relates to pyrazole carboxamides as inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase Type I (11.beta.-HSD-1 or HSD-1) and methods of treating certain conditions using such compounds. The compounds of the present invention are useful for the
Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
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TECHNICAL FIELD
The present invention relates to pyrazole derivatives, pharmaceutically acceptable salts thereof or prodrugs thereof which are useful as medicaments, pharmaceutical compositions comprising the same, pharmaceutical uses thereof and intermediates for production thereof.
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Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
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This application is a national stage application of PCT/JP03/10551, filed Aug. 21, 2003, which claims priority to foreign applications JP2002-244381, filed Aug. 23, 2002, and JP2002-324076, field Nov. 7, 2002.
TECHNICAL FIELD
The present invention relates to pyrazole derivatives, pharmaceutically
Pyrazole compounds
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This invention relates to pyrazole compounds or pharmaceutically acceptable salts thereof. Compounds of this invention are inhibitors of methionine aminopeptidase 2 (MetAP2) and dipeptidyl peptidase-4 (DPP-4).
MetAP2 is a metalloproteinase that cleaves initiator methionine from nascent peptide
Piperazinyl-propyl-pyrazole derivatives as dopamine D4 receptor antagonists, and pharmaceutical compositions containing the same
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CROSS REFERENCE TO RELATED APPLICATION
This application claims the priority of Korean Patent Application No. 10-2007-0022845, filed on Mar. 8, 2007 in the KIPO (Korean Intellectual Property Office), the disclosure of which are incorporated herein in their entirety by reference. Further, this
Piperazinyl-propyl-pyrazole derivatives as dopamine D4 receptor antagonists, and pharmaceutical compositions containing the same
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TECHNICAL FIELD
The present invention relates to a piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable salt comprising the same.
BACKGROUND ART
Dopamine is a neurotransmitter essential for neuronal signal transduction in animal brains including
Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
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TECHNICAL FIELD
The present invention relates to pyrazole derivatives, pharmaceutically acceptable salts thereof or prodrugs thereof which are useful as medicaments, pharmaceutical compositions comprising the same, pharmaceutical uses thereof and intermediates for production thereof.
More
Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
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TECHNICAL FIELD
The present invention relates to pyrazole derivatives, pharmaceutically acceptable salts thereof or prodrugs thereof which are useful as medicaments, pharmaceutical compositions comprising the same, pharmaceutical uses thereof and intermediates for production thereof.
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Pyrazole derivatives as cannabinoid receptor antagonists
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FIELD OF THE INVENTION
The present invention relates generally to pyrazole derivatives and is more particularly concerned with new and improved pyrazole derivatives exhibiting high binding affinities for cannabinoid receptors, pharmaceutical preparations employing these analogs and methods of
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