The present invention provides compounds of Formula (I) ##STR00001## and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprising such compounds, their preparation, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF).

Aventis Pharmaceuticals Inc.

Pyrazoles as inhibitors of tumor necrosis factor

Pyrazole derivatives useful for inhibiting the production of Interleukin-1 (IL-1) and tumor necrosis factor (TNF) and the like, which can be represented by the following formula: ##STR1## and a pharmaceutical composition containing the same and to uses thereof.

Fujisawa Pharmaceutical Co., Ltd.

Pyrazole derivatives

Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R.sup.1 is --CH(OH)--CH(R.sup.4)-(A).sub.n-Y, --CH.sub.2--CH(R.sup.4)-(A).sub.n-Y, --CO-B.sup.1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R.sup.4 is a hydrogen atom or a lower alkyl group; B.sup.1 is --CH(R.sup.4)-- or --N(R.sup.4)--; and n is 0 or 1); R.sup.2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R.sup.3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor .alpha.-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases ##STR00001##

Teikoju Hormone Mfg. Co., Ltd.

Substituted pyrazole compounds

Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R.sup.1 is --CH(OH)--CH(R.sup.4)--(A).sub.n --Y, --CH.sub.2 --CH(R.sup.4)--(A).sub.n --Y, --CO--B.sup.1 --A--Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R.sup.4 is a hydrogen atom or a lower alkyl group; B.sup.1 is --CH(R.sup.4)-- or --N(R.sup.4)--; and n is 0 or 1); R.sup.2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R.sup.3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor .alpha.-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases. ##STR1##

Teikoku Hormone Mfg. Co., Ltd.

This invention relates to heterocyclic derivatives useful for inhibiting the production of Interleukin-1 (IL-1) and tumor necrosis factor (TNF) and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to uses thereof.

pyrazole/nekros

Pyrazoles as inhibitors of tumor necrosis factor

Pyrazole derivatives

Substituted pyrazole compounds

Substituted pyrazole compounds

Pyrazole derivatives

Den mest kompletta databasen med medicinska örter som stöds av vetenskapen