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Sida 1 från 164 resultat
Fused pyrazole derivatives, preparation method thereof, and use thereof in treatment of cancers, inflammation and immune diseases
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TECHNICAL FIELD
The present invention relates to novel fused pyrazole derivatives and their pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising these compounds, and to methods of preparing these compounds. The present invention also relates to use of the fused
Pyrazoles as inhibitors of tumor necrosis factor
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This invention is directed to a series of pyrazoles, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF).
P38 kinase is
Methods of treating cancer with a pyrazole derivative
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The present invention relates to pyrazole derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.
Protein kinases are a class of proteins (enzymes) that regulate a variety of
Pyrazole compounds as HSP90 inhibitors for the treatment of cancer
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This application is a National Stage application of co-pending PCT application PCT/GB2004/001740, filed Apr. 23, 2004, which claims the priority of Great Britain Patent Application No. 0309637.7, filed Apr. 28, 2003. These applications are incorporated herein by reference in their entireties.
This
Derivatives of 3-hydroxy-4-(cyclyl-alkylaminoalkyl)-5-phenyl-1h-pyrazole as antagonists of the gonadotropin releasing hormone (GnRH) for use in the treatment of sex hormone related conditions, such as prostatic of uterine cancer
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a US National Stage under 35 U.S.C 371 of International Application No. PCT/GB2003/003633, filed Aug. 19, 2003, which claims priority under 35 U.S.C. .sctn. 119(a)-(d) to European Patent Application No. 02292077.1 filed on Aug. 21, 2002,
3-(2-hydroxy-phenyl)-1H-pyrazole-4-carboxylic acid amide derivatives as HSP90 inhibitors for the treatment of cancer
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This application is a U.S. National Stage application of co-pending PCT application PCT/GB2003/005275, filed Dec. 4, 2003, which claims the priority of Great Britain Patent Application No. 0228417.2, filed Dec. 5, 2002. These applications are incorporated herein by reference in their
Fused pyrazole derivatives as TGF-.beta. signal transduction inhibitors for the treatment of fibrosis and neoplasms
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The invention relates to new compounds and their use as pharmaceutical agents, in particular their use as TGF-.beta. signal transduction inhibitors.
BACKGROUND OF THE INVENTION
The transforming growth factor-beta (TGF-beta) ("TGF-.beta.") polypeptides influence growth, differentiation, and gene
Indeno[1,2-c]-, naphtho[1,2-c]- and benzo[6,7]cyclohepta[1,2-c]pyrazole derivatives
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BACKGROUND OF THE INVENTION
Protein tyrosine kinases (PTKs) comprise a large and diverse class of proteins having enzymatic activity. The PTKs play an important role in the control of cell growth and differentiation (for review, see Schlessinger & Ullhrich, 1992, Neuron 9:383-391).
For example,
CSF-1R inhibitors for treatment of brain tumors
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BACKGROUND
Cancers of the brain and nervous system are among the most difficult to treat. Prognosis for patients with these cancers depends on the type and location of the tumor as well as its stage of development. For many types of brain cancer, average life expectancy after symptom onset may be
Pyrazole derivatives
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This invention relates to new heterocyclic derivatives. More particularly, this invention relates to pyrazole derivatives and pharmaceutically acceptable salts thereof which have pharmacological activities, processes for preparation thereof, a pharmaceutical composition comprising the same and a use
Amino pyrazole compound
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Janus kinase 2 (JAK2) is a member of the tyrosine kinase family which is involved in cytokine signaling. JAK2 has a pivotal role in the erythropoietin (EPO) signaling pathway, including erythrocyte differentiation and Stat5 activation. Recent studies have demonstrated that patients with chronic
Pyrazole compounds
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FIELD OF INVENTION
It has become increasingly clear in recent years that cell death is as important to the health of a multicellular organism as cell division: where proliferation exists, so must a means of regulating its cellular progeny. By repeated cell division and differentiation throughout
Pyrazole compounds
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BACKGROUND OF THE INVENTION
It has become increasingly clear in recent years that cell death is as important to the health of a multicellular organism as cell division: where proliferation exists, so must a means of regulating its cellular progeny. By repeated cell division and differentiation
Pyrazole compounds
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BACKGROUND OF THE INVENTION
It has become increasingly clear in recent years that cell death is as important to the health of a multicellular organism as cell division: where proliferation exists, so must a means of regulating its cellular progeny. By repeated cell division and differentiation
Fused pyrazoles as FGFR inhibitors
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FIELD OF THE INVENTION
The present invention relates to fused pyrazole derivatives, and pharmaceutical compositions including the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
BACKGROUND OF THE INVENTION
The
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