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Pyridine derivatives
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This invention relates to pyridine derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
Up to now, of the compounds having a pyridine skeleton, it has been reported that 2-isopropyl-3-nicotinylindole(L-8027) possesses an inhibitory activity on
Pyridine derivatives
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This invention relates to pyridine derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
Up to now, of the compounds having a pyridine skeleton, it has been reported that 2-isopropyl-3-nicotinylindole(L-8027) possesses an inhibitory activity on
Pyridine alkyl benzoic and thenoic acid compounds and their pharmaceutical compositions
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This invention relates to pyridine derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
Up to now, of the compounds having a pyridine skeleton, it has been reported that 2-isopropyl-3-nicotinylindole(L-8027) possesses an inhibitory activity on
Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT.sub.2A serotonin receptor useful for the treatment of disorders related thereto
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FIELD OF THE INVENTION
The present invention relates to certain imidazo[1,2-.alpha.]pyridine derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds of Formula (Ia) and pharmaceutical compositions thereof are
Imidazo[1,2-.alpha.]pyridine derivatives as modulators of the 5-HT.sub.2A serotonin receptor useful for the treatment of disorders related thereto
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FIELD OF THE INVENTION
The present invention relates to certain imidazo[1,2-a]pyridine derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds of Formula (Ia) and pharmaceutical compositions thereof are directed
Pyridine derivative
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TECHNICAL FIELD
The present invention relates to a pyridine derivative having an ability to act as a neurotrophic factor and a salt thereof.
BACKGROUND ART
It has been suggested that in Alzheimer's disease, which has recently been increasing in prevalence, degeneration and dysfunction of cholinergic
Pyridine compounds and their pharmaceutical use
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TECHNICAL FIELD
This invention relates to new pyridine compounds. More particularly, this invention relates to new pyridine compounds and pharmaceutically acceptable salts thereof which have pharmacological activities, a process for preparation thereof, a pharmaceutical composition comprising the
Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to compounds that inhibit the activity of protein kinases. Protein kinases are enzymes that catalyze the transfer of a phosphate group from ATP to an amino acid residue, such as tyrosine, serine, threonine, or histidine on a protein. Regulation of
Novel carboxamide pyridine compounds which have useful pharmaceutical utility
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The present invention relates to new carboxamides and sulfonamides of the general formula
in which
A denotes a radical ##STR1##
B denotes a radical ##STR2##
W denotes --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CH.dbd.CH--CH.sub.2 --, --(CH.sub.2).sub.3 --, --CH.sub.2 CH(CH.sub.3)--,
Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines
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This invention relates to novel substituted vinyl derivatives which are capable of inhibiting thromboxane A.sub.2 (TXA.sub.2) synthetase specifically.
TXA.sub.2 is one of the arachidonic acid metabolites and is a potent inducer of platelet aggregation and vascular smooth muscle contractions.
Imidazo[1,5-a]pyridine derivatives and methods for treating aldosterone mediated diseases
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The present invention provides compounds of the formula (I)
##STR00002## wherein R.sub.1 is cycloalkyl, heterocyclyl or an aryl radical of the formula
##STR00003## in which R.sub.4 is cycloalkyl, aryl or heterocyclyl; or R.sub.4 is optionally substituted alkyl, alkoxy, hydroxy, halogen or
Imidazo[[1, 5-A] pyridine derivatives and methods for treating aldosterone mediated diseases
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The present invention provides compounds of the formula (I)
##STR00002## wherein R.sub.1 is cycloalkyl, heterocyclyl or an aryl radical of the formula
##STR00003## in which R.sub.4 is cycloalkyl, aryl or heterocyclyl; or R.sub.4 is optionally substituted alkyl, alkoxy, hydroxy, halogen or
Process for preparing 2,4- dihydroxypyridine and 2,4- dihydroxy-3-nitropyridine
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to processes for preparing 2,4-dihydroxypyridine and 2,4-dihydroxy-3-nitropyridine which compounds are intermediates that are useful in preparing adenosine compounds and analogs thereof which are useful in treating
Use of nicorandil in treatment of sexual dysfunction or for enhancement of sexual function in mammals including humans
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FIELD OF THE INVENTION
The present invention relates to the use of nitric ester of N-(2-hydroxyethyl) nicotinamide in the treatment of impotence in animals, including humans. More particularly, the present invention relates to the use of N-(2-Hydroxyethyl) nicotinamide, commonly referred to as
Substituted heterocyclic compounds and methods of use
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BACKGROUND OF THE INVENTION
T cells play a pivotal role in the regulation of immune responses and are important for establishing immunity to pathogens. In addition, T cells are often activated during inflammatory autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, type I
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