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[On the problem of cryptogenetic processes of brain atrophy: quantitative measurements of cerebral circulation and cerebral glucose, lactic acid and pyruvic acid metabolism].

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Indole-pyruvic acid treatment reduces damage in striatum but not in hippocampus after transient forebrain ischemia in the rat.

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The effects of treatment with indole-pyruvic acid, an endogenous metabolite of tryptophan converted into kynurenic acid in the brain, were studied in rats after transient forebrain ischemia induced by the 4-vessel occlusion procedure. The histological analysis showed a significant protective effect

Storage stability of solutions of pyruvic acid/glycine used in adhesive bonding.

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The rate of deterioration of pyruvic acid/glycine solutions used as common pretreatment of enamel and dentin in the Gluma bonding technique was investigated. Bond strengths between composite resin and enamel/dentin were measured. The bonds were mediated by pyruvic acid/glycine solutions, applied

[Prevention of ulcerogenesis at experimental pancreatitis].

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OBJECTIVE We wanted to study the mechanisms of "Dimefosfon" influence on ulcerogenesis prevention in acute pancreatitis. METHODS The study was conducted on 36 dogs. We were modeling of edematous form of pancreatitis: fulfilled the median laparotomy, punctured of the gall bladder bile were taken, it

[A 60-year-old man with intention tremor as an initial symptom followed by cerebellar ataxia, peripheral neuropathy and dementia].

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We report a 60-year-old man with a 6-year history of tremor in his hands. He noted the onset of short of breath and gait disturbance in 1994; both of these symptoms were slowly progressive. Then recently he developed fever two months prior to the present admission. He was admitted to the

[A case of mitochondrial myopathy with external ophthalmoplegia and ataxic neuropathy].

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We report a 70-year-old woman with bilateral optic atrophy, external ophthalmoplegia, bilateral blepharoptosis, and sensory ataxic neuropathy. She had a visual disturbance since childhood. She had dysarthria and gait disturbance at 28 years old. She had bilateral blepharoptosis, marked gait

[Myoclonus epilepsy with ragged-red fibers: a case report and literature review].

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To demonstrate the clinical manifestation, diagnosis and treatment of myoclonus epilepsy with ragged-red-fibers (MERRF), a case of MERRF was presented with review of the literature. A 4-year-7-month-old girl was diagnosed with MERRF. She had tremor, fatigue and developmental delay for more than 2

The role of glycolysis and gluconeogenesis in the cytoprotection of neuroblastoma cells against 1-methyl 4-phenylpyridinium ion toxicity.

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1-Methyl-4-phenylpyridinium (MPP+) is a mitochondrial Complex I inhibitor and is frequently used to investigate the pathological degeneration of neurons associated with Parkinson's disease (PD). In vitro, extracellular concentration of glucose is one of the most critical factors in establishing the

Changes in transcription and metabolism during the early stage of replicative cellular senescence in budding yeast.

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Age-related damage accumulates and a variety of biological activities and functions deteriorate in senescent cells. However, little is known about when cellular aging behaviors begin and what cellular aging processes change. Previous research demonstrated age-related mRNA changes in budding yeast by

In vitro maturation of canine oocytes co-cultured with bovine and canine granulosa cell monolayers.

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The present study investigated the effects of bovine granulosa cell monolayers (BGML) and canine granulosa cell monolayers (CGML) on nuclear maturation of canine oocytes with and without cumulus cells. Cumulus-oocyte complexes (COCs) or cumulus-free oocytes were cultured in Dulbecco's Modified

[A case of MELAS with G13513A mutation presenting with chronic kidney disease long before stroke-like episodes].

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The patient was a 35-year-old female with an 9-year history of chronic kidney disease awaiting renal transplantation. She was brought to hospital by ambulance due to a generalized convulsive seizure. Her consciousness remained disturbed after treatment for her seizure, and sensorineural deafness was

A case of Kearns-Shy syndrome with later onset.

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We report a case of Kearns-Shy syndrome in a 44-year-old woman. She complained of bilateral ptosis, exotropia and gait disturbance. Diffuse chorioretinal degeneration and numerous punctate whitish spots were observed in both fundi. Eye movements were severely disturbed. An electroretinogram was

[Cerebrocortical necrosis in calves, sheep and goats].

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Cerebrocortical necrosis was induced through the oral application of amprolium to calves (0.250 g/kg to 1.00 g/kg) and weaned lambs and goats (1.25 g/kg) in the course of 25 to 35 days. In order to shed light on the etiology of the disease an experiment was carried out with a ration rich in

Systemic effects and skin injury after experimental dermal exposure to monochloroacetic acid.

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There have been many fatal occupational accidents of skin exposure to monochloroacetic acid (MCA). However, there have been no reports of dermatological findings and the lethal consequences have not yet been demonstrated. Therefore, harmful local and systemic effects were investigated after dermal

[Pyruvate dehydrogenase deficit associated to the C515T mutation in exon 6 of the E1alpha gene].

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BACKGROUND Pyruvate dehydrogenase (PDH) deficiency constitutes the most frequent metabolic origin of congenital lactic acidosis and is also responsible for a less usual form, found exclusively in females, which leads to a dysmorphic syndrome accompanied by severe cerebral malformations. The most

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