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retinopathy of prematurity/hypoxia

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Automatic Oxygen Control for Reducing Extremes of Oxygen Saturation (AreOS): A Randomised Control Trial

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Supplemental oxygen remains by far the most commonly used 'drug' in neonatal intensive care units. The goal of oxygen therapy is to maintain normal oxygenation while minimizing hypoxemia and hypoxemia. Preterm infants are particularly vulnerable to oxygen toxicity and oxidative stress leading to

Multimodal Monitoring of Hemodynamics in Extremely Low Birth Weight Preterm Infant in a Canadian Tertiary Level Unit

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Background: Neonatal transition from the intra-uterine to extra-uterine environment is a complex, multi-organ process. The heart of a term neonate is anatomically and functionally mature to make the transition. However, the feto-neonatal transition of Extremely Low Gestational Age Neonates (ELGAN)

Safeguarding the Brain of Our Smallest Infants Phase III

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Background Each year, 50,000 extremely preterm infants are born in high-income countries with access to neonatal intensive care. Of these, 10,000 will die and a further 10,000 will suffer cerebral palsy or moderate-to-severe neuro-cognitive disability. Time spent outside normal cerebral oxygenation

Comparison of Automated Oxygen Control With and Without Automated Pressure Control in Preterm Ventilated Infants.

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Supplemental oxygen remains by far the most commonly used 'drug' in neonatal intensive care units. The goal of oxygen therapy is to maintain normal oxygenation while minimizing hyperoxaemia and hypoxemia. Preterm infants are particularly vulnerable to oxygen toxicity and oxidative stress leading to

Effects of Closed-loop Automatic Control of FiO2 in Extremely Preterm Infants

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Effects of Early Vitamin A Supplementation on the Risk for Retinopathy of Prematurity in Extremely Preterm Infants

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Retinopathy of prematurity (ROP) is a common retinal neovascular disorder and major cause of vision impairment or blindness, despite current treatment of late stage ROP. Because the visual disorders after treatment are often poor, preventive therapy for ROP is still lacking. Although ROP is a

Oral Propranolol Improve Retinopathy of Prematurity Outcomes in Very Preterm Infants

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Retinopathy of prematurity (ROP) is a major cause of blindness and visual impairment in children in both developing and developed countries around the world. ROP is a multifactorial disease characterized by perturbation of normal vascular development in the retina. The pathogenesis of ROP is

Proper Pressure and Duration of Sustained Lung Inflation in Preterm Infants

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This study will be a randomized prospective pilot study in Mansoura University Hospital then the cases were followed at Neonatal Intensive Care Unit in Mansoura University Children Hospital, Mansoura, Egypt. Preterm infants born equal to or less than 32 weeks gestation with respiratory distress

Intermittent Hypoxemia and Acute Kidney Injury Study (IHAKI Study)

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BACKGROUND: Preterm birth is a major health care concern and although survival of premature infants has improved, the incidence of neonatal morbidities has slightly decreased especially in cases of extreme prematurity. Apnea of prematurity (immature respiratory control) is a major complication in

Non-invasive Intervention for Apnea of Prematurity

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Aim: To study the effect of limb proprioceptive stimulation using a vibratory device on apneic events, intermittent hypoxic episodes and bradycardias in a premature infant with apnea of prematurity. The objective is to provide support and to assist impaired ventilation and oxygenation in apnea of

Small Step Intervention for Infants With Cerebral Palsy and Other Neurodevelopmental Disorders

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Rational for subject selection: Signs of CP may be visible already during the first months, but according to recommendations the diagnosis of CP should typically not be made until 2-4 years of age. The reason is that the individual developmental trajectories of muscle tone, postural control and

Pan-VEGF Blockade for the Treatment of Retinopathy of Prematurity (BLOCK-ROP)

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Retinopathy of Prematurity (ROP) is a leading cause of blindness in children in developed countries around the world, and an increasing cause of blindness in developing countries. The retina lines the inside of the eye. It functions as "film" within the camera, which is the eye. When an infant is

Oxygen Saturation Alarms in the Neonatal Intensive Care Unit

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False alarms may be particularly prevalent in the neonatal intensive care unit (NICU) where uncontrolled motion of infants can intensify the problem. The performance of pulse oximeters is of particular importance in the NICU because of the danger that both hyperoxemia and hypoxemia pose to newborns;

Clinical Evaluation of a Closed Loop Oxygen Controller for Neonatal Respiratory Care

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Nearly forty years ago Berran and coworkers tested an analog oxygen controller to maintain incubator oxygen levels for infants suffering neonatal respiratory disease in order to prevent hyperoxia. 1. The system was able to regulate to within 1% of the set inspired oxygen level and resulted in stable
Retinopathy of Prematurity (ROP) is a leading cause of blindness in children in developed countries around the world, and an increasing cause of blindness in developing countries. The retina lines the inside of the eye. It functions as "film" within the camera which is the eye. When an infant is
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