As a control to the experimental design, timepoint 0 was considered.

Absorption

After overnight fasting, the authorized study staff inserted a plastic cannula in an arm vein of the volunteers in order to minimize discomfort during consecutive blood sampling. A blood sample was collected on time point 0h and then the volunteers consumed 1mL of MO. The dose selection was based on the study of Papada et al. (2017) who administered healthy volunteers with 10g of Mastiha (containing ~10% MO). Afterwards blood samples were collected on time points 0.5h, 1h, 2h, 4h, 6h and 24h after MO intake, and were centrifuged at 3000rpm for 10 minutes at 4◦C for plasma and serum isolation. All samples were stored at -80◦C until further analysis.

Mastiha oil

Harokopio University

Absorption and Bioavailability of Major Monoterpenes in Mastiha Oil; a Kinetic Study in Humans.

The monoterpenes will be identified and quantified in plasma samples applying GC-MS-MS. Data will be presented through study completion in plasma concentration (μg/L).

Andriana C Kaliora

Assistant Professor in Foods and Human Nutrition

8 weeks of 25 g/day of milled chia supplemented-isocaloric diet

Non-Alcoholic Fatty Liver Disease

Dietary Modification

8 weeks of an isocaloric diet supplemented with 25 g/day of milled chia

Milled chia seeds

Chia Supplementation and Non Alcoholic Fatty Liver Disease

Effect of a Chia Supplemented Diet (Salvia Hispanica) on the Cardiometabolic Risk Profile in Patients With NAFLD (Non Alcoholic Fatty Liver Disease)

To assess the effect of 25 g/day of milled chia in 25 patients with NAFLD.Improvement of LSAI (liver spleen attenuation index) measured by computed tomography In a single-arm experimental design study

Increase in Alpha linolenic acid with chia supplemented diet. Measured by gas chromatography.

Improvement of lipid parameters (total colesterol, LDL-C, triglycerides, HDL-C) including free fatty acids

Aida Medina Urrutia

Medical sience investigator

Instituto Nacional de Cardiologia Ignacio Chavez

Biological Availability

The volunteers will follow a low-phytochemical diet for five days, meaning that they will exclude fruits, vegetables, legumes, coffee, tea, alcoholic beverages and chocolate. On the day of the experiment and after overnight fasting, the volunteers will consume 10g of natural Mastiha and blood samples will be obtained on timepoints 0h, 30min, 1h, 2h, 4h, 6h and 24h after Mastiha intake. Until timepoint 6h, will be allowed to consume only water. Urine samples will also be collected on timepoints 0h, 4h, 8h and 24h.

Mastiha

Bioavailability of the Microconstituents of Natural Chios Mastiha in Healthy Adults.

A Bioavailability Study of the Natural Chios Mastiha in Blood and Urine Samples of Healthy Adults.

"Assistant Professor in Foods & Human Nutrition"

Patients receive Salvia hispanica seed PO QD for 12 weeks.

Adult Nasal Type Extranodal NK/T-Cell Lymphoma

Adult T-Cell Leukemia/Lymphoma

Anaplastic Large Cell Lymphoma

Angioimmunoblastic T-Cell Lymphoma

B Lymphoblastic Leukemia/Lymphoma

Blastic Plasmacytoid Dendritic Cell Neoplasm

Burkitt Leukemia

Central Nervous System Lymphoma

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Diffuse Large B-Cell Lymphoma

Enteropathy-Associated T-Cell Lymphoma

Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

Grade 1 Follicular Lymphoma

Grade 2 Follicular Lymphoma

Grade 3 Follicular Lymphoma

Hepatosplenic T-Cell Lymphoma

Lymphoplasmacytic Lymphoma

Mantle Cell Lymphoma

Mediastinal (Thymic) Large B-Cell Lymphoma

Mycosis Fungoides

Nasal Type Extranodal NK/T-Cell Lymphoma

Nodal Marginal Zone Lymphoma

Peripheral T-Cell Lymphoma, Not Otherwise Specified

Post-Transplant Lymphoproliferative Disorder

Primary Cutaneous Anaplastic Large Cell Lymphoma

Primary Effusion Lymphoma

Sezary Syndrome

Splenic Marginal Zone Lymphoma

Subcutaneous Panniculitis-Like T-Cell Lymphoma

Systemic Anaplastic Large Cell Lymphoma

T Lymphoblastic Leukemia/Lymphoma

Transformed Recurrent Non-Hodgkin Lymphoma

Laboratory Biomarker Analysis

Quality-of-Life Assessment

Questionnaire Administration

Salvia hispanica Seed

Mayo Clinic

Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma

A Pilot Feasibility Trial of the Tolerability of Oral Salvia Hispanica and Its Effect on Blood Fatty Acids and Stool Microbiome in Patients With Treated Non-Hodgkin Lymphoma

n-3 level will be evaluated as a continuous measure, where the median and range will be summarized at each time point. Changes across time will be evaluated graphically. Changes from baseline will be quantitatively summarized and will be evaluated using paired sample methods (paired sample t-test).

The evaluation of whether changes in n-3 levels persist or resolve after participants are no longer taking SH will be assessed using a paired t test comparing the mean values at 12 weeks to the mean values at 16 weeks. Changes from week 12 to week 16 will also be calculated and the mean magnitude of change will be explored.

The evaluation of whether changes in stool microbiome persist or resolve after participants are no longer taking SH will be assessed using a paired t test comparing the mean values at 12 weeks to the mean values at 16 weeks. Changes from week 12 to week 16 will also be calculated and the mean magnitude of change will be explored.

Patient's initial sample will provide a control to assess alterations in stool deoxyribonucleic acid (DNA) (reflecting stool bacterial populations) after supplementation with SH. Measurable change will be assessed based on standardized methods.

Safety and tolerability will be assessed utilizing stool and symptom diaries. The maximum grade for each type of adverse event will be recorded for each patient, and frequency tables will be reviewed to determine patterns. The relationship of the adverse event(s) to the study treatment will be taken into consideration. In addition, tolerability will be further assessed by evaluating the number of doses missed due to adverse events. Reasons for missed doses will be summarized.

Patient compliance in stool sample collection will be assessed by evaluating the percentage of patients who provide a sample at each time point. The percentage of patients who provide samples for 0, 1, 2, 3, or all 4 time points will be calculated to determine the feasibility of requesting multiple samples on future studies.

National Cancer Institute (NCI)

Type 2 Diabetes

Salba diet

St. Michael's Hospital

Effect of Chia Seeds (Salvia Hispanica L.) on Glucose Control in Patients With Type 2 Diabetes

St. Michael's Hospital, Toronto

salvia ringens

antioxidant

salvia

salvia ringens/antioxidant

Absorption and Bioavailability of Major Monoterpenes in Mastiha Oil; a Kinetic Study in Humans.

Chia Supplementation and Non Alcoholic Fatty Liver Disease

Bioavailability of the Microconstituents of Natural Chios Mastiha in Healthy Adults.

Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma

Effect of Chia Seeds (Salvia Hispanica L.) on Glucose Control in Patients With Type 2 Diabetes

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