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Sida 1 från 23 resultat
Quantitative Structure-Activity Relationships Analysis, Homology modeling, Docking and Molecular Dynamics studies of triterpenoid saponins as Kirsten Rat Sarcoma Inhibitors.
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Oncogenic Kirsten RAt Sarcoma (KRAS) mutations are attractive targets in non-small cell lung cancer (NSCLC). Thus, the objective of this work is to discover promising inhibitors that target this protein using in silico methods that have become increasingly cost-effective in research and development
Saponin from Tupistra chinensis Bak Inhibits NF-κB Signaling in Sarcoma S-180 Cell Mouse Xenografts.
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This study examined the effect of saponins from Tupistra chinensis Bak (STCB) on the growth of sarcoma S-180 cells in vitro and in mouse xenografts as well as the underlying mechanisms. Cell proliferation was assessed by MTT assay. Cell cycle distribution was determined by flow cytometry. Sarcoma
[Saponin from Tupistra chinensis Baker inhibits mouse sarcoma S-180 cell proliferation in vitro and implanted solid tumor growth in mice].
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OBJECTIVE
To study the antitumor effect of saponin extracted from Tupistra chinensis Baker (STCB) against mouse sarcoma S-180 cell proliferation in vitro and in vivo and explore the primary mechanism of this effect.
METHODS
Cytotoxic effect of STCB on S-180 cells in vitro was evaluated by MTT
Cytotoxicity of the saponin TTB2 on Ewing sarcoma cells.
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The steroidal saponin TTB2 can be isolated from the n-BuOH extracts of Trillium tschonoskii Maxim. The aim of the present study was to observe whether this saponin exerted any cytotoxic effects on malignant sarcoma cells, and to further investigate the possible underlying molecular mechanisms. The
[Effect of panaxadiol-saponins from ginseng flowers and leaves on DNA synthesis in mouse ascitic reticulocytic sarcoma cells].
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Prolonged survival of AKR mice treated with the saponin adjuvant Quil A.
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Treatment of AKR mice with the saponin Quil A delayed their death in spontaneous leukaemia. In vitro tests did not demonstrate any influence on infection of rat cells with Kirsten sarcoma virus. Quil A in the concentration nanogram/ml doubled the mitogen response of AKR spleen cells to
Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells.
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We studied the immunocytochemical localization of urokinase-type plasminogen activator (u-PA) and the type 1 plasminogen activator inhibitor (PAI-1) in human fibroblasts and sarcoma cells, using both polyclonal and monoclonal antibodies. The u-PA was found to be located at discrete cell-substratum
Cytoskeletal properties of alveolar soft part sarcoma.
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The immunohistochemical expression of cytoskeletal proteins in alveolar soft part sarcoma (ASPS) was studied by light and electron microscopy. Of the five cases examined by the avidinbiotin-peroxidase complex method, variable numbers of immunoreactive cells for desmin were found in three, for
TTB2 induces apoptosis in Ewing sarcoma cells.
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A steroidal saponin named pennogenin 3-O-α-L-rhamnopyranosyl-(1→2) [α-L-rhamnopyranosyl-(1→4)]-β-D-glucoyranoside(TTB2) has been successfully separated from the n-BuOH extracts of Trillium tschonoskii Maxim and is able to induce cytotoxicity to some types cancer cells. The present study aimed to
Antitumor activities of dammarane triterpene saponins from Bacopa monniera.
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Bioassay-guided methods were used to test the antitumor activity of methanol extract of the whole plant of Bacopa monniera (L.) Wettst. and four different fractions (petroleum ether, CHCl(3), EtOAc, and n-BuOH fractions) of the methanol extract. Among the five crude samples, n-BuOH fraction was
Immunomodulatory and antitumoral effects of triterpenoid saponins.
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Genuine saponins of Solidago virgaurea L., Heteropappus altaicus (Willd.) Novopokr., Heteropappus biennis (Ldb.) Tamamsch. and Helianthus annuus L. (Asteraceae) as well as related carbohydrate modified glycosides of polygalacic acid and echinocystic acid and some commercial available triterpenoid
[Study on the anticancer activities of the Clematis manshrica saponins in vivo].
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OBJECTIVE
To study the anticancer activity of the Clematis manshrica saponins in vivo.
METHODS
Anticancer activities were tested in mice with experimental tumor (S180, HepA and P388) in vivo.
RESULTS
The Clematis manshrica saponins showed a significant anticancer activities on Sarcoma-180, HepA and
Anti-tumour and immunomodulating activities of diosgenin, a naturally occurring steroidal saponin.
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Diosgenin is a naturally occurring steroidal saponin abundantly present in many medical plants. In this study, diosgenin could significantly inhibit the growth of sarcoma-180 tumour cells in vivo, and remarkably increase thymus and spleen weights of S-180-bearing mice and upgrade the secretion level
Anti-angiogenic activity of convallamaroside, the steroidal saponin isolated from the rhizomes and roots of Convallaria majalis L.
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Angiogenesis plays a pivotal role in tumor growth and represents a key target for chemopreventive intervention. Despite the large number of existing angiogenesis inhibitors, there is still a great demand for new anti-angiogenic compounds. The objective of this study is to investigate the effect of
Anti-angiogenic effect of triterpenoidal saponins from Polygala senega.
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Senegasaponins [senegin II (1), senegin III (2), senegin IV (3), senegasaponin a (4), and senegasaponin b (5)] from Polygala senega were re-discovered as selective anti-proliferative substances against human umbilical vein endothelial cells (HUVECs). Senegasaponins (1-5) showed anti-proliferative
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