Novel superoxide dismutase derivatives are provided in which the enzymatic activity of superoxide dismutase capable of decomposing superoxide, a substance harmful to living organisms, is for the most part maintained with the plasma half-life being significantly prolonged as compared with superoxide dismutase itself. They have pharmacological activities such as anti-inflammatory, anti-ischemic and cerebral edema-preventing activities. Also provided are a method of producing such superoxide dismutase derivatives and medicinal uses of them.

Inoue; Masayasu

Kuraray Co., Ltd.

Superoxide dismutase derivatives, method of producing same and medicinal use of same

The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.

Novartis AG

Superoxide dismutase mimics for the treatment of ocular disorders and diseases

Alcon, Inc.

The use of SOD mimics particularly pentaazacycle Mn(II) complex SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.

superoxide dismutase/ödem

Superoxide dismutase derivatives, method of producing same and medicinal use of same

Superoxide dismutase mimics for the treatment of ocular disorders and diseases

Superoxide dismutase mimics for the treatment of ocular disorders and diseases

Superoxide dismutase mimics for the treatment of ocular disorders and diseases

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