patients undergoing thyroidectomy for nodular thyroid disease

Postsurgical Hypothyroidism

Hypothyroidism

Patients enrolled in the study will undergo a clinically-indicated thyroidectomy performed as standard of care.

thyroidectomy

Patients will initiate levothyroxine treatment after surgery consistent with standard of care. The drug dosage will be titrated to TSH goal that matches the pre-surgery TSH (+/- 1 mIU/L)

levothyroxine in thyroidectomy patients

University of Colorado Anschutz Medical Campus

Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?

Is Levothyroxine Alone Adequate Thyroid Hormone Replacement for All Patients?

Change in working memory as assessed by pre- vs post-surgery N-back test scores will be measured and compared between those with the deiodinase type 2 CC polymorphism versus those in the deiodinase type 2 TC and TT polymorphism group

Changes in cognitive function assessed by SART testing pre- and post-surgery will be compared between those with the deiodinase type 2 CC polymorphism versus those in the deiodinase type 2 TC and TT polymorphism group

Changes in well-being will be assessed with the SF-36, Billewicz, and HADS tests pre- and post-surgery will be compared between those with the deiodinase type 2 CC polymorphism versus those in the deiodinase type 2 TC and TT polymorphism group

Pre- vs post-surgery N-back test scores will be measured and correlated with pre- and post-surgery serum thyronamine levels

Cognitive function assessed by SART testing pre- and post-surgery will be determined and correlated with pre- and post-surgery serum thyronamine levels

Well-being will be assessed with the SF-36, Billewicz, and HADS tests pre- and post-surgery and will be correlated with serum thyronamine levels pre- and post-surgery

changes in serum thyronamine levels from pre-surgery to end of study (post-surgery) will be assessed

changes in serum sex hormone binding globulin levels from pre-surgery to end of study (post-surgery) will be assessed

changes in serum LDL levels from pre-surgery to end of study (post-surgery) will be assessed

University of Colorado, Denver

Charite University, Berlin, Germany

Hepatitis C, Chronic

ORAL RENESSANS 5gm. Twice Daily +INTERFERON ALPHA 2b 3 Million Units s/c +RIBAVIRIN 15mg/kg

RENESSANS , INTERFERON ALPHA 2b, Ribavirin

INTERFERON ALPHA 2b 3 Million Units s/c +RIBAVIRIN 15mg/kg

Interferon Alfa-2b AND RIBAVIRIN

ORAL RENESSANS 5gm. Thrice Daily{active iodine 300mg} for 6months

RENESSANS

Medical Unit 1,Lahore General Hospital,Postgraduate Medical Institute

To Study the Efficacy and Safety of Renessans in Chronic HCV Patients

An Open Labelled, Active Controlled, Three Arm, Parallel- Group Study of the Safety and Efficacy of Renessans Administered Alone and in Combination With Standard Interferon Therapy in Patients Chronic HCV Hepatitis

Efficacy will be assessed by biochemical and virological response. Biochemical response will be assessed in the form of mean decline in ALT from baseline at 3 month and end of treatment. Virological response will be assessed in the form of response guided therapy i-e RVR [negative RNA at week 4],EVR [negative RNA at 12 weeks],ETR [negative RNA at end of treatment] and SVR[negative PCR after 6 month of completion of therapy].

Safety will be assessed by Adverse event and Serious adverse events.

thyroiditis/albumin

Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?

To Study the Efficacy and Safety of Renessans in Chronic HCV Patients

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