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5 resultat
Long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies induce oxidative stress in rat brain.
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Accumulation of long-chain 3-hydroxy fatty acids is the biochemical hallmark of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) and mitochondrial trifunctional protein (MTP) deficiencies. These disorders are clinically characterized by neurological symptoms, such as convulsions and lethargy, as
A new generation of cysteine derivatives with three active antioxidant centers: improving reactivity and stability.
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The development of new antioxidants with enhanced activity constitutes a very active research field as it can contribute to the improvement of human health. Although the antioxidant activity occurs through different mechanisms, usually most of the antioxidant molecules present a unique active center
Prostaglandin H synthase. Effects of peroxidase cosubstrates on cyclooxygenase velocity.
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Many cosubstrates for the peroxidase activity of prostaglandin H synthase-1 (PGHS-1) have been reported to produce a large (2-7-fold) increase in the cyclooxygenase velocity in addition to a substantial increase in the number of cyclooxygenase catalytic turnovers. The large stimulation of
Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm.
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Prolonged mechanical ventilation (MV) results in diaphragmatic weakness due to fiber atrophy and contractile dysfunction. Recent work reveals that activation of the proteases calpain and caspase-3 is required for MV-induced diaphragmatic atrophy and contractile dysfunction. However, the mechanism(s)
Inverse association between dietary habits with high total antioxidant capacity and prevalence of frailty among elderly Japanese women: a multicenter cross-sectional study.
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OBJECTIVE
To examine the association of dietary habits with high total antioxidant capacity (TAC) with frailty among elderly Japanese women.
METHODS
Cross-sectional multicenter study.
METHODS
Thirty-five of 47 prefectures in Japan.
METHODS
2121 grandmothers or acquaintances of dietetic students aged
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