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The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study
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Over one million infants are born to HIV-1-infected women every year in Sub Saharan Africa. In Zimbabwe, annual births stand at 379,000 with approximately 48,000 infants being born every year to HIV-1-infected women on lifelong highly active antiretroviral therapy (HAART). Concerns have been
2000 HIV Human Functional Genomics Partnership Program
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Study population:
A cohort with a total of 2000 HIV patients will be built, consisting of a discovery cohort (n=1200) and confirmation cohort (n=800). The investigators estimate a 2-year inclusion and 2-year follow-up period and will strive for the inclusion of several clinical phenotypes such as
Diagnosis of Ascites in Infants and Children
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Definition : Ascites is the pathologic fluid accumulation within the peritoneal cavity .
causes of ascites in infants and children :
- Hepatobiliary disorders (cirrhosis, congenital hepatic fibrosis, acute hepatitis B,C ,Budd -chiari syndrome, Bile duct perforation)
- Serositis (crohn's disease,
Calciotropic Effects After hCG Stimulation Test
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Introduction:
hCG signals through the LHCGR receptor and is know to stimulate testosterone production. hCG stimulation tests are therefore used to evaulate the capacity of the testis to respond to LH/hCG and thereby determine the degree og gonadal insufficiency and need for testosterone
Pharmacokinetic and Pharmacodynamic Study of High-Dose Rifapentine and Moxifloxacin for Treatment of Tuberculosis
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RIFAPENTINE
Rifapentine is approved by the United States Food and Drug Administration for treatment of drug-susceptible pulmonary TB based on an open-label prospective randomized phase 3 study of 722 participants with pulmonary TB. Rifapentine has a longer half-life than rifampin, but both drugs
Vitamin D and the Free Hormone Hypothesis
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Introduction:
Vitamin D is a versatile signaling molecule with a well-established role in the regulation of calcium homeostasis and bone health. The spectrum of vitamin D target-organs has expanded and it has been suggested that vitamin D influences the immune system, endocrine organs such as
Effect of Supplementary Vitamin D in Patients With Diabetes Mellitus and Pulmonary Tuberculosis
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Pakistan is going through an epidemiological transition that subjects it to a dual burden of communicable and chronic diseases. According to WHO, Pakistan ranks seventh in diabetes prevalence and fifth amongst high TB burden countries. Pakistan faces challenges in controlling both these diseases
Screening of Subjects With Type I Diabetes to Determine Eligibility for Islet Transplantation
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Subjects with Type 1 diabetes and history of severe hypoglycemia will undergo screening similar to the screening done for islet transplantation including: history; physical; chest X rays; upper GI series if history of ulcer; abdominal and pelvic ultrasound with careful attention to liver parenchyma
Efficacy and Safety of Top-down Therapy in Pediatric Crohn's Disease
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This is a single-center, open-label, randomized, prospective, controlled trial evaluating the efficacy and safety of infliximab (IFX) as first line therapy in children with moderate-to-severe CD. The estimated duration of the study is 36 months, including a recruitment phase of 12 months, a
Sonoelastography: Ultrasound Method to Measure Liver Fibrosis
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BACKGROUND Chronic liver disease is an important cause of morbidity and mortality in the United States. A retrospective cohort study identified 2,353 patients with newly diagnosed chronic liver disease (63.9 cases/100,000 population). Extrapolating this incidence rate there will be approximately
Nutrition in Children With Food Allergy
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Prospective controlled study including patients with cow's milk allergy(6-36 months of age.During the first examination, the diagnosis will be assessed by pediatricians with great experience in food allergy, checking that the patient had undergone a standardized procedure. All cases with an unclear
Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica
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The duration of the study will be 1 year, and it will be divided in several phases:
A) Initial phase (double-blind trial): Between week 0 and week 24. Placebo or Infliximab at a dose of 3 mg/kg/day at weeks 0, 2 and 6.
After the screening process, patients who meet the inclusion/exclusion criteria
Infectious Causes of Uveitis
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All patients included eye examination that includes split-lamp examination with semi-quantification evaluation of the inflammation, fundoscopy incl. picture, and angiography.
Hemoglobin (Hb), Erythrocyte-volume fraction (EVF), Middle cell volume (MCV), middelcell hemoglobin concentration (MCHC),
Phase I/Randomized Phase II Study of Second Line Therapy With Irinotecan + Cetuximab +/- RAD001 for Colorectal Cancer
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OUTLINE: This is a multi-center study.
PHASE I:
- UGT1A1 *28 7/7 genotype IS NOT present
- Cetuximab 250 mg/m2 IV days 1, 8, and 15
- Irinotecan 125 mg/m2 IV days 1 and 8
- RAD001 PO QD (dose determined at the time of registration; subjects will remain at this dose level until treatment
Cytokines and Acute Phase Reactants as Markers of Pulmonary Tuberculosis Treatment
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Tuberculosis is a highly prevalent chronic infectious disease caused by Mycobacterium tuberculosis. Cytokines are important biological mediators that regulate immune and inflammatory responses against the bacilli, witch include the acute phase response. Besides this, it becomes essential to
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