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8 resultat
Tyrosine kinase inhibitors
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BACKGROUND OF THE INVENTION
The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis,
Polymorphs with tyrosine kinase activity
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BACKGROUND OF THE INVENTION
The present invention relates to active polymorphs of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperazine-1-carboxyl ic acid methylamide, which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these polymorphs,
Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors
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BACKGROUND OF THE INVENTION
The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis,
Indeno[1,2-C]pyrazole derivatives for inhibiting tyrosine kinase activity
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BACKGROUND OF THE INVENTION
Protein tyrosine kinases (PTKs) comprise a large and diverse class of proteins having enzymatic activity. The PTKs play an important role in the control of cell growth and differentiation (for review, see Schlessinger & Ullrich, 1992, Neuron 9:383-391).
For example,
Multi-tyrosine kinase inhibitors derivatives and methods of use
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BACKGROUND OF THE INVENTION
Many intraocular diseases, such as proliferative retinopathies, occur due to neovascularization and/or leakage, which are caused in part by elevated vascular endothelial growth factor ("VEGF") levels. These diseases include, but are not limited to, diabetic macular edema,
Quinoline derivatives and their use as tyrosine kinase inhibitors
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FIELD OF THE INVENTION
The present invention relates to quinoline derivatives and to the use thereof in therapy. More particularly, the present invention relates to quinoline derivatives for the treatment of cancer, diabetic retinopathy, age-related macular degeneration, inflammation, stroke,
Quinoline derivatives and their use as tyrosine kinase inhibitors
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FIELD OF THE INVENTION
The present invention relates to quinoline derivatives and to the use thereof in therapy. More particularly, the present invention relates to quinoline derivatives for the treatment of cancer, diabetic retinopathy, age-related macular degeneration, inflammation, stroke,
Protection against endothelial barrier dysfunction through inhibition of the tyrosine kinase abl-related gene (ARG)
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The invention relates to the field of endothelial barrier dysfunction. In particular, the invention relates to new methods for the treatment of syndromes/diseases characterized by endothelial barrier dysfunction, such as inflammatory edema.
Abl protein non-receptor tyrosine kinases are involved in
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