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LC-MS determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional chinese medicinal preparation Lu-Ying extract.

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Sambucus chinensis L. is a native perennial herb distributed throughout China. In traditional Chinese medicine (TCM), this herb is known as Lu-Ying. Ursolic acid is the major effective constituent of Lu-Ying. A rapid, sensitive, and accurate liquid chromatography-mass spectrometry (LC-MS) method for

Ursolic acid, a pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet.

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Currently, there is renewed interest in plant-based medicines and functional foods for the prevention and cure of obesity and its associated risk of cardiovascular disease and metabolic syndrome. In the search for potential anti-obesity compounds from natural sources, the effects of ursolic acid

[Determination of ursolic acid of Sambucus adnata].

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HPLC was used to determine the content of ursolic acid of Sambucus adnata from different origins. The content of ursolic acid range between 1.14 to 5.7 microg, r = 0.999 8, the recovery range from 99.8% to 101.3%. The method is quick, sensitive and repeatable for determination of the content of

Antibacterial and antioxidant activities of ursolic acid and derivatives.

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Ursolic acid, an important bioactive compound, was isolated from ethanol extract of aerial parts of Sambucus australis. In order to develop bioactive ursolic acid derivatives, two semi-synthetic compounds were obtained through modification at C-3. The antibacterial activity of the ursolic acid and

Bioactive triterpenoids from Sambucus javanica Blume.

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A new triterpene, javablumine A (1) along with six known ones were isolated from the aerial parts of Sambucus javanica Blume. They were identified as 3β,23-dihydroxy-11α,12α-epoxy-urs-20(30)-en-28,13β-olide (1), ursolic acid (2), pomolic acid (3), oleanic acid (4), 2α-hydroxy-oleanolic acid (5),

[Study on the chemical constituents of Sambucus chinensis Lindl].

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OBJECTIVE To study the chemical constituents of Sambucus chinensis Lindl. METHODS The constituents were isolated and purified by various chromatographic methods and structurally identified by spectral analysis. RESULTS 5 compounds were obtained as beta-sitosterol (I), oleanolic acid (II), ursolic

Triterpenoid Acids as Important Antiproliferative Constituents of European Elderberry Fruits.

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In Europe, both the fruits and flowers of Sambucus nigra L. have been used against cold, as well as laxative, diaphoretic, and diuretic remedies. There are also a number of commercially available food products that contain elderberry juice, puréed or dried elderberries. Recent comprehensive

Determination of ursolic and oleanolic acid in Sambuci fructus.

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Elderberries are used in the preparation of pie, jelly, punch, wine, or liqueur, as well as in many herbal remedies and food supplements. Elderberry products may provide diaphoretic, diuretic, antioxidant, and immunostimulant activities that offer protection against cold and flu. Herein, we report

[Studies on chemical constituents of Sambucus adnata].

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OBJECTIVE To study the chemical constituents of Sambucus adnata. METHODS Compounds were isolated by silica gel chromatography. Their structures were elucidated by means of spectral analysis. RESULTS Five compounds were isolated and identified as: 1-(3-hydroxy4-methoxyphenyl)-1',2'-ethanediol (1),

Chemical constituents from Sambucus adnata and their protein-tyrosine phosphatase 1B inhibitory activities.

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The MeOH extract from the whole plants of Sambucus adnata has shown significant protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity. Chemical study on the extract resulted in the isolation of thirteen compounds, including a novel triterpene (1). The structure of 1 was determined to be

Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.).

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OBJECTIVE The performed investigations aimed on the identification of the anti-inflammatory principal of extracts of leaves of Sambucus ebulus L. (dwarf elder) in order to rationalize the traditional use of this plant for the treatment of chronically inflammatory diseases. METHODS Dwarf elder leaf

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