Vinca herbacea / neoplasms

10'-fluorinated Vinca alkaloids provide enhanced biological activity against MDR cancer cells

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BACKGROUND ART Vinca alkaloids, originally isolated from the periwinkle plant [Vinca rosea Linn., now Cantharanthus roseus (L.) G. Don] are a family of indole-indoline dimeric compounds that contain a four-ring system containing an indole linked to a five-ring system containing an indoline. Two of

Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties

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FIELD OF THE INVENTION This invention relates to the fields of biochemistry and medicine, and particularly to a pharmaceutical preparation which includes liposome-entrapped water soluble drug formulations, and methods of using such formulations to control the delivery of encapsulated agents to

Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties

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FIELD OF THE INVENTION This invention relates to the fields of biochemistry and medicine, and particularly to a pharmaceutical preparation which includes liposome-entrapped water soluble drug formulations, and methods of using such formulations to control the delivery of encapsulated agents to

Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties

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FIELD OF THE INVENTION This invention relates to the fields of biochemistry and medicine, and particularly to a pharmaceutical preparation which includes liposome-entrapped water soluble drug formulations, and methods of using such formulations to control the delivery of encapsulated agents to

Method for treating cancers using a diiodo thyronine analogue having no significant hormonal activity and a vinca alkaloid and compositions comprising the same

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The present invention is in the field of biochemistry and pharmacology. Specifically, the present invention relates to methods for treating cancers and malignancies by administering a pharmaceutically effective amount of a diiodo thyronine analogue having no significant hormonal activity and a vinca

Liposome-encapsulated vinca alkaloids and their use in combatting tumors

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to the use of vinca alkaloids in combatting tumors. 2. Discussion of the Background The dimeric alkaloids, vincristine and vinblastine, containing indol-indoline moieties from Catharanthus species are widely used as

Vinca alkaloid intermediates

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BACKGROUND OF THE INVENTION Several naturally-occurring alkaloids obtainable from Vinca rosea have been found active in the treatment of experimental malignancies in animals. Among these are leurosine (U.S. Pat. No. 3,370,057), vincaleukoblastine (vinblastine) to be referred to hereinafter as VLB

Oxazolidinedione derivatives of Vinca alkaloids

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BACKGROUND OF THE INVENTION Several naturally-occurring alkaloids obtainable from Vinca rosea have been found active in the treatment of experimental malignancies in animals. Among these are leurosine (U.S. Pat. No. 3,370,057), vincaleukoblastine (vinblastine) to be referred to hereinafter as VLB

Preparation of oxazolidinedione derivatives of Vinca alkaloids

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BACKGROUND OF THE INVENTION Several naturally-occurring alkaloids obtainable from Vinca rosea have been found active in the treatment of experimental malignancies in animals. Among these are leurosine (U.S. Pat. No. 3,370,057), vincaleukoblastine (vinblastine) to be referred to hereinafter as VLB

Use of vinca alkaloids and salts thereof

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TECHNICAL FIELD The present invention relates to the use of vinca alkaloids and their salts. More specifically, the present invention relates to agents that enhance insulin-producing and/or -secreting abilities of non-neoplastic cells derived from the pancreas, therapeutic agents for diabetes, blood

vinca herbacea/neoplasms

10'-fluorinated Vinca alkaloids provide enhanced biological activity against MDR cancer cells

Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties

Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties

Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties

Method for treating cancers using a diiodo thyronine analogue having no significant hormonal activity and a vinca alkaloid and compositions comprising the same

Liposome-encapsulated vinca alkaloids and their use in combatting tumors

Vinca alkaloid intermediates

Oxazolidinedione derivatives of Vinca alkaloids

Preparation of oxazolidinedione derivatives of Vinca alkaloids

Use of vinca alkaloids and salts thereof

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